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学科主题: 临床医学
题名:
Macrophage Migration Inhibitory Factor for the Early Prediction of Infarct Size
作者: Chan, William1; White, David A.3; Wang, Xin-Yu4; Bai, Ru-Feng3; Liu, Yang3; Yu, Hai-Yi4; Zhang, You-Yi4; Fan, Fenling3; Schneider, Hans G.2; Duffy, Stephen J.1,5; Taylor, Andrew J.1,5; Du, Xiao-Jun3,5; Gao, Wei4; Gao, Xiao-Ming3,6; Dart, Anthony M.1,3,5
关键词: infarct size ; macrophage migration inhibitory factor ; myocardial infarction
刊名: JOURNAL OF THE AMERICAN HEART ASSOCIATION
发表日期: 2013-10-01
DOI: 10.1161/JAHA.113.000226
卷: 2, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; PERCUTANEOUS CORONARY INTERVENTION ; LEFT-VENTRICULAR FUNCTION ; CARDIAC TROPONIN ASSAYS ; EARLY-DIAGNOSIS ; REPERFUSION INJURY ; I ASSAY ; ELEVATION ; HEART ; ANGIOPLASTY
英文摘要:

Background-Early diagnosis and knowledge of infarct size is critical for the management of acute myocardial infarction (MI). We evaluated whether early elevated plasma level of macrophage migration inhibitory factor (MIF) is useful for these purposes in patients with ST-elevation MI (STEMI).

Methods and Results-We first studied MIF level in plasma and the myocardium in mice and determined infarct size. MI for 15 or 60 minutes resulted in 2.5-fold increase over control values in plasma MIF levels while MIF content in the ischemic myocardium reduced by 50% and plasma MIF levels correlated with myocardium-at-risk and infarct size at both time-points (P<0.01). In patients with STEMI, we obtained admission plasma samples and measured MIF, conventional troponins (TnI, TnT), high sensitive TnI (hsTnI), creatine kinase (CK), CK-MB, and myoglobin. Infarct size was assessed by cardiac magnetic resonance (CMR) imaging. Patients with chronic stable angina and healthy volunteers were studied as controls. Of 374 STEMI patients, 68% had elevated admission MIF levels above the highest value in healthy controls (>41.6 ng/mL), a proportion similar to hsTnI (75%) and TnI (50%), but greater than other biomarkers studied (20% to 31%, all P<0.05 versus MIF). Only admission MIF levels correlated with CMR-derived infarct size, ventricular volumes and ejection fraction (n=42, r=0.46 to 0.77, all P<0.01) at 3 day and 3 months post-MI.

Conclusion-Plasma MIF levels are elevated in a high proportion of STEMI patients at the first obtainable sample and these levels are predictive of final infarct size and the extent of cardiac remodeling.

语种: 英语
所属项目编号: 472628 ; 472600 ; 472600 ; APP1052960 ; PB 10M 5481
项目资助者: National Health and Medical Research Council (NHMRC) of Australia ; NHMRC ; Australian National Heart Foundation ; Victorian Government&prime ; s Operational Infrastructure Support Program
WOS记录号: WOS:000326343200002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62906
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Alfred Hosp, Dept Pathol, Melbourne, Vic, Australia
2.Peking Univ, Hosp 3, Beijing 100871, Peoples R China
3.Alfred Hosp, Dept Cardiovasc Med, Melbourne, Vic, Australia
4.Baker IDI Heart & Diabet Inst, Melbourne, Vic, Australia
5.Monash Univ, Cent Clin Sch, Dept Med, Melbourne, Vic 3004, Australia
6.Monash Univ, Cent Clin Sch, Dept Surg, Melbourne, Vic 3004, Australia

Recommended Citation:
Chan, William,White, David A.,Wang, Xin-Yu,et al. Macrophage Migration Inhibitory Factor for the Early Prediction of Infarct Size[J]. JOURNAL OF THE AMERICAN HEART ASSOCIATION,2013,2(5).
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