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学科主题临床医学
The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome
Hu, Zhiping; Wang, Ying; Qiao, Jie; Li, Meizhi; Chi, Hongbin; Chen, Xinna
关键词Family history Metformin Oral contraceptives Polycystic ovary syndrome
刊名INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
2010
DOI10.1016/j.ijgo.2009.08.004
108期:1页:35-39
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology
研究领域[WOS]Obstetrics & Gynecology
关键词[WOS]IMPAIRED GLUCOSE-TOLERANCE ; ACTIVATED PROTEIN-KINASE ; METABOLIC SYNDROME ; INSULIN-RESISTANCE ; PREVALENCE ; METFORMIN ; PCOS ; FLUTAMIDE ; PROFILE
英文摘要

Objective: To investigate the association between family history and clinical symptoms of polycystic ovary syndrome (PCOS) that were thought to be inherited, by treating women with PCOS with contraceptive pills and metformin, and assessing Outcomes. Methods: Of 164 women with PCOS, 49 with menstrual abnormalities, hyperandrogenism, and abnormal glucose and/or insulin levels underwent a 3-month treatment with contraceptive pills and metformin. Family history was taken, and physical and ultrasound examinations were performed. Serum levels of glucose, insulin, lipoproteins, lipids, and reproductive hormones were measured before and after treatment. Results: The serum levels of low-density lipoprotein, total cholesterol, apolipoprotein 13, and triglycerides were higher in the patients with a family history of the studied symptoms than in those with no such family history. After treatment, changes in testosterone and glucose levels; glucose area under curve, and homeostasis model assessment value differed in the 2 groups. Conclusion: The patients with a family history of PCOS symptoms thought to be inherited were more sensitive to oral contraceptive and metformin treatment. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd.All rights reserved.

语种英语
WOS记录号WOS:000273911000010
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62909
专题北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Reprod Med Ctr, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hu, Zhiping,Wang, Ying,Qiao, Jie,et al. The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,2010,108(1):35-39.
APA Hu, Zhiping,Wang, Ying,Qiao, Jie,Li, Meizhi,Chi, Hongbin,&Chen, Xinna.(2010).The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome.INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,108(1),35-39.
MLA Hu, Zhiping,et al."The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome".INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS 108.1(2010):35-39.
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