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学科主题: 临床医学
题名:
The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome
作者: Hu, Zhiping; Wang, Ying; Qiao, Jie; Li, Meizhi; Chi, Hongbin; Chen, Xinna
关键词: Family history ; Metformin ; Oral contraceptives ; Polycystic ovary syndrome
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
发表日期: 2010
DOI: 10.1016/j.ijgo.2009.08.004
卷: 108, 期:1, 页:35-39
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: IMPAIRED GLUCOSE-TOLERANCE ; ACTIVATED PROTEIN-KINASE ; METABOLIC SYNDROME ; INSULIN-RESISTANCE ; PREVALENCE ; METFORMIN ; PCOS ; FLUTAMIDE ; PROFILE
英文摘要:

Objective: To investigate the association between family history and clinical symptoms of polycystic ovary syndrome (PCOS) that were thought to be inherited, by treating women with PCOS with contraceptive pills and metformin, and assessing Outcomes. Methods: Of 164 women with PCOS, 49 with menstrual abnormalities, hyperandrogenism, and abnormal glucose and/or insulin levels underwent a 3-month treatment with contraceptive pills and metformin. Family history was taken, and physical and ultrasound examinations were performed. Serum levels of glucose, insulin, lipoproteins, lipids, and reproductive hormones were measured before and after treatment. Results: The serum levels of low-density lipoprotein, total cholesterol, apolipoprotein 13, and triglycerides were higher in the patients with a family history of the studied symptoms than in those with no such family history. After treatment, changes in testosterone and glucose levels; glucose area under curve, and homeostasis model assessment value differed in the 2 groups. Conclusion: The patients with a family history of PCOS symptoms thought to be inherited were more sensitive to oral contraceptive and metformin treatment. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd.All rights reserved.

语种: 英语
所属项目编号: JHG06-7-03
项目资助者: Department of Education in China
WOS记录号: WOS:000273911000010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62909
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Hosp 3, Reprod Med Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Hu, Zhiping,Wang, Ying,Qiao, Jie,et al. The role of family history in clinical symptoms and therapeutic outcomes of women with polycystic ovary syndrome[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,2010,108(1):35-39.
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