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学科主题: 临床医学
题名:
Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats
作者: Wu, Haiyan; Liang, Yaoxian; Zheng, Yimu; Bai, Qiong; Zhuang, Zheng; Lata, A.; Zheng, Danxia; Wang, Yue
关键词: Angiotensinogen ; Angiotensin II ; High-salt diet ; Hypertension ; Intrarenal RAS
刊名: KIDNEY & BLOOD PRESSURE RESEARCH
发表日期: 2014
DOI: 10.1159/000368463
卷: 39, 期:6, 页:526-535
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physiology ; Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]: Physiology ; Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]: ANGIOTENSIN-CONVERTING ENZYME ; BLOOD-PRESSURE ; DIETARY SALT ; TRANSGENIC MICE ; KIDNEY-DISEASE ; RECEPTORS ; LOSARTAN ; THERAPY ; OXIDASE ; INJURY
英文摘要:

Background/Aims: To investigate the change of intrarenal renin-agiotensin system (RAS) and its role in high-salt induced hypertension. Methods: Wistar rats were divided into normal-salt (NS), high-salt diet (HS) and high-salt diet with Losartan group (HS + L), for 6 weeks. Systolic blood pressure (SBP) was monitored. Blood and urine samples were collected every 2 weeks. Angiotensinogen (AGT) was measured by ELISA. AGT mRNA and protein were measured by real-time PCR and immunohistochemistry. Renin activity and angiotensin II (Ang II) were measured by radioimmunoassay. Results: HS versus NS group, SBP increased from 2nd week (P<0.05), urinary protein increased at 6th week (P<0.05). Although plasma renin, AGT and Ang II had no significant changes (P>0.05), renal cortex renin, AGT, and Ang II increased significantly in HS (P<0.05). In HS + L, Losartan failed to reduce SBP (P>0.05) but abolished the increase of proteinuria (P<0.01), renal cortex renin, AGT, Ang II and urinary AGT reduced (P<0.05) while plasma renin, AGT and Ang II enhanced (P<0.05) when compared with HS. Urinary AGT was positively correlated with renal AGT (r=0.592, P<0.01) and Ang II (r=0.726, P<0.01). Conclusion: Inappropriate response of the renal RAS to a high salt diet may contribute to hypertension and renal damage, and urinary AGT could reflect intrarenal RAS activity. Copyright (C) 2014 S. Karger AG, Basel

语种: 英语
所属项目编号: 81070213
项目资助者: National Nature Science Foundation of China
WOS记录号: WOS:000347728100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62911
Appears in Collections:北京大学第三临床医学院_肾内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China

Recommended Citation:
Wu, Haiyan,Liang, Yaoxian,Zheng, Yimu,et al. Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats[J]. KIDNEY &amp; BLOOD PRESSURE RESEARCH,2014,39(6):526-535.
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