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Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats
Wu, Haiyan; Liang, Yaoxian; Zheng, Yimu; Bai, Qiong; Zhuang, Zheng; Lata, A.; Zheng, Danxia; Wang, Yue
关键词Angiotensinogen Angiotensin II High-salt diet Hypertension Intrarenal RAS
刊名KIDNEY & BLOOD PRESSURE RESEARCH
2014
DOI10.1159/000368463
39期:6页:526-535
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physiology ; Urology & Nephrology ; Peripheral Vascular Disease
研究领域[WOS]Physiology ; Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]ANGIOTENSIN-CONVERTING ENZYME ; BLOOD-PRESSURE ; DIETARY SALT ; TRANSGENIC MICE ; KIDNEY-DISEASE ; RECEPTORS ; LOSARTAN ; THERAPY ; OXIDASE ; INJURY
英文摘要

Background/Aims: To investigate the change of intrarenal renin-agiotensin system (RAS) and its role in high-salt induced hypertension. Methods: Wistar rats were divided into normal-salt (NS), high-salt diet (HS) and high-salt diet with Losartan group (HS + L), for 6 weeks. Systolic blood pressure (SBP) was monitored. Blood and urine samples were collected every 2 weeks. Angiotensinogen (AGT) was measured by ELISA. AGT mRNA and protein were measured by real-time PCR and immunohistochemistry. Renin activity and angiotensin II (Ang II) were measured by radioimmunoassay. Results: HS versus NS group, SBP increased from 2nd week (P<0.05), urinary protein increased at 6th week (P<0.05). Although plasma renin, AGT and Ang II had no significant changes (P>0.05), renal cortex renin, AGT, and Ang II increased significantly in HS (P<0.05). In HS + L, Losartan failed to reduce SBP (P>0.05) but abolished the increase of proteinuria (P<0.01), renal cortex renin, AGT, Ang II and urinary AGT reduced (P<0.05) while plasma renin, AGT and Ang II enhanced (P<0.05) when compared with HS. Urinary AGT was positively correlated with renal AGT (r=0.592, P<0.01) and Ang II (r=0.726, P<0.01). Conclusion: Inappropriate response of the renal RAS to a high salt diet may contribute to hypertension and renal damage, and urinary AGT could reflect intrarenal RAS activity. Copyright (C) 2014 S. Karger AG, Basel

语种英语
WOS记录号WOS:000347728100003
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62911
专题北京大学第三临床医学院_肾内科
北京大学第二临床医学院_肾内科
北京大学第三临床医学院_职业病科
作者单位Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
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GB/T 7714
Wu, Haiyan,Liang, Yaoxian,Zheng, Yimu,et al. Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats[J]. KIDNEY &amp; BLOOD PRESSURE RESEARCH,2014,39(6):526-535.
APA Wu, Haiyan.,Liang, Yaoxian.,Zheng, Yimu.,Bai, Qiong.,Zhuang, Zheng.,...&Wang, Yue.(2014).Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats.KIDNEY & BLOOD PRESSURE RESEARCH,39(6),526-535.
MLA Wu, Haiyan,et al."Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats".KIDNEY & BLOOD PRESSURE RESEARCH 39.6(2014):526-535.
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