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Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats
Wu, Haiyan; Liang, Yaoxian; Zheng, Yimu; Bai, Qiong; Zhuang, Zheng; Lata, A.; Zheng, Danxia; Wang, Yue
关键词Angiotensinogen Angiotensin II High-salt diet Hypertension Intrarenal RAS
刊名KIDNEY & BLOOD PRESSURE RESEARCH
2014
DOI10.1159/000368463
39期:6页:526-535
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physiology ; Urology & Nephrology ; Peripheral Vascular Disease
资助者National Nature Science Foundation of China ; National Nature Science Foundation of China
研究领域[WOS]Physiology ; Urology & Nephrology ; Cardiovascular System & Cardiology
关键词[WOS]ANGIOTENSIN-CONVERTING ENZYME ; BLOOD-PRESSURE ; DIETARY SALT ; TRANSGENIC MICE ; KIDNEY-DISEASE ; RECEPTORS ; LOSARTAN ; THERAPY ; OXIDASE ; INJURY
英文摘要

Background/Aims: To investigate the change of intrarenal renin-agiotensin system (RAS) and its role in high-salt induced hypertension. Methods: Wistar rats were divided into normal-salt (NS), high-salt diet (HS) and high-salt diet with Losartan group (HS + L), for 6 weeks. Systolic blood pressure (SBP) was monitored. Blood and urine samples were collected every 2 weeks. Angiotensinogen (AGT) was measured by ELISA. AGT mRNA and protein were measured by real-time PCR and immunohistochemistry. Renin activity and angiotensin II (Ang II) were measured by radioimmunoassay. Results: HS versus NS group, SBP increased from 2nd week (P<0.05), urinary protein increased at 6th week (P<0.05). Although plasma renin, AGT and Ang II had no significant changes (P>0.05), renal cortex renin, AGT, and Ang II increased significantly in HS (P<0.05). In HS + L, Losartan failed to reduce SBP (P>0.05) but abolished the increase of proteinuria (P<0.01), renal cortex renin, AGT, Ang II and urinary AGT reduced (P<0.05) while plasma renin, AGT and Ang II enhanced (P<0.05) when compared with HS. Urinary AGT was positively correlated with renal AGT (r=0.592, P<0.01) and Ang II (r=0.726, P<0.01). Conclusion: Inappropriate response of the renal RAS to a high salt diet may contribute to hypertension and renal damage, and urinary AGT could reflect intrarenal RAS activity. Copyright (C) 2014 S. Karger AG, Basel

语种英语
所属项目编号81070213
资助者National Nature Science Foundation of China ; National Nature Science Foundation of China
WOS记录号WOS:000347728100003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62911
专题北京大学第三临床医学院_肾内科
作者单位Peking Univ, Hosp 3, Dept Nephrol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Wu, Haiyan,Liang, Yaoxian,Zheng, Yimu,et al. Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats[J]. KIDNEY &amp; BLOOD PRESSURE RESEARCH,2014,39(6):526-535.
APA Wu, Haiyan.,Liang, Yaoxian.,Zheng, Yimu.,Bai, Qiong.,Zhuang, Zheng.,...&Wang, Yue.(2014).Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats.KIDNEY & BLOOD PRESSURE RESEARCH,39(6),526-535.
MLA Wu, Haiyan,et al."Up-Regulation of Intrarenal Renin-Agiotensin System Contributes to Renal Damage in High-Salt Induced Hypertension Rats".KIDNEY & BLOOD PRESSURE RESEARCH 39.6(2014):526-535.
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