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学科主题: 药学
题名:
Population pharmacokinetics of cyclosporine in clinical renal transplant patients
作者: Wu, KH; Cui, YM; Guo, JF; Zhou, Y; Zhai, SD; Cui, FD; Lu, W
刊名: DRUG METABOLISM AND DISPOSITION
发表日期: 2005-09-01
DOI: 10.1124/dmd.105.004358
卷: 33, 期:9, 页:1268-1275
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: HEART-TRANSPLANTATION ; RECIPIENTS ; DILTIAZEM ; DISPOSITION ; METABOLITES ; VALIDATION ; PARAMETERS ; INHIBITORS ; MODEL ; C-2
英文摘要:

Population pharmacokinetics of cyclosporine (CsA) in clinical renal transplant patients has been reported in the present study. A total of 2548 retrospective drug monitoring data points were collected from 120 renal transplant patients receiving CsA. Population modeling was performed using the NONMEM (nonlinear mixed-effect modeling) program, using a one-compartment model with first-order absorption and elimination. The final regression model for CsA clearance (CL/F) with the influence of six significant covariates, comprising postoperative days (POD), total bilirubin level (TBIL, micromolar concentration), current body weight (CBW, kilograms), age (years), concurrent metabolic inhibitors of cyclosporine (INHI), and hematocrit (HCT, percentage), has been established and expressed as CL/F = 28.5 - 1.24 . POD - 0.252 . (TBIL = 11) + 0.188 . (CBW - 58) -0.191 . (Age - 42) -2.45 . INHI - 0.212 . (HCT - 28) (liters per hour). The values in parentheses represent the median level for each of the corresponding covariates. The population estimates for CL/F (28.5 l/h), V/F (volume of distribution, 133 l), and interpatient variability (CV% = 19.7%) for CL/F were achieved, respectively. The population model was further validated by internal and external approaches, and was demonstrated to be effective and stable. Moreover, simulation was conducted to facilitate the individualized treatment based on patient information and the final model.

语种: 英语
WOS记录号: WOS:000231357800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62912
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: 1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang, Peoples R China
3.Peking Univ First Hosp, Dept Pharm, Beijing, Peoples R China
4.Peking Univ Third Hosp, Beijing, Peoples R China

Recommended Citation:
Wu, KH,Cui, YM,Guo, JF,et al. Population pharmacokinetics of cyclosporine in clinical renal transplant patients[J]. DRUG METABOLISM AND DISPOSITION,2005,33(9):1268-1275.
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