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Population pharmacokinetics of cyclosporine in clinical renal transplant patients
Wu, KH; Cui, YM; Guo, JF; Zhou, Y; Zhai, SD; Cui, FD; Lu, W
刊名DRUG METABOLISM AND DISPOSITION
2005-09-01
DOI10.1124/dmd.105.004358
33期:9页:1268-1275
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]HEART-TRANSPLANTATION ; RECIPIENTS ; DILTIAZEM ; DISPOSITION ; METABOLITES ; VALIDATION ; PARAMETERS ; INHIBITORS ; MODEL ; C-2
英文摘要

Population pharmacokinetics of cyclosporine (CsA) in clinical renal transplant patients has been reported in the present study. A total of 2548 retrospective drug monitoring data points were collected from 120 renal transplant patients receiving CsA. Population modeling was performed using the NONMEM (nonlinear mixed-effect modeling) program, using a one-compartment model with first-order absorption and elimination. The final regression model for CsA clearance (CL/F) with the influence of six significant covariates, comprising postoperative days (POD), total bilirubin level (TBIL, micromolar concentration), current body weight (CBW, kilograms), age (years), concurrent metabolic inhibitors of cyclosporine (INHI), and hematocrit (HCT, percentage), has been established and expressed as CL/F = 28.5 - 1.24 . POD - 0.252 . (TBIL = 11) + 0.188 . (CBW - 58) -0.191 . (Age - 42) -2.45 . INHI - 0.212 . (HCT - 28) (liters per hour). The values in parentheses represent the median level for each of the corresponding covariates. The population estimates for CL/F (28.5 l/h), V/F (volume of distribution, 133 l), and interpatient variability (CV% = 19.7%) for CL/F were achieved, respectively. The population model was further validated by internal and external approaches, and was demonstrated to be effective and stable. Moreover, simulation was conducted to facilitate the individualized treatment based on patient information and the final model.

语种英语
WOS记录号WOS:000231357800002
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被引频次:32[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62912
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
2.Shenyang Pharmaceut Univ, Shenyang, Peoples R China
3.Peking Univ First Hosp, Dept Pharm, Beijing, Peoples R China
4.Peking Univ Third Hosp, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wu, KH,Cui, YM,Guo, JF,et al. Population pharmacokinetics of cyclosporine in clinical renal transplant patients[J]. DRUG METABOLISM AND DISPOSITION,2005,33(9):1268-1275.
APA Wu, KH.,Cui, YM.,Guo, JF.,Zhou, Y.,Zhai, SD.,...&Lu, W.(2005).Population pharmacokinetics of cyclosporine in clinical renal transplant patients.DRUG METABOLISM AND DISPOSITION,33(9),1268-1275.
MLA Wu, KH,et al."Population pharmacokinetics of cyclosporine in clinical renal transplant patients".DRUG METABOLISM AND DISPOSITION 33.9(2005):1268-1275.
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