北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学公共卫生学院  > 期刊论文
学科主题: 公共卫生
题名:
Determination of zygosity by questionnaire and physical features comparison in Chinese adult twins
作者: Gao, WJ; Li, LM; Cao, WH; Zhan, SY; Lv, J; Qin, Y; Pang, ZC; Wang, SJ; Chen, WJ; Chen, RF; Hu, YH
刊名: TWIN RESEARCH AND HUMAN GENETICS
发表日期: 2006-04-01
卷: 9, 期:2, 页:266-271
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Obstetrics & Gynecology
研究领域[WOS]: Genetics & Heredity ; Obstetrics & Gynecology
关键词[WOS]: YOUNG TWINS ; DIAGNOSIS
英文摘要:

This study reports on the determination of zygosity in Chinese adult twins by simple questionnaire and physical features comparison. The subjects were 511 twin pairs from two cities and their town areas, consisting of 371 monozygotic (MZ) and 140 same-sex dizygotic (DZ) pairs, identified by ABO blood group and multiplex polymerase chain reaction of several polymorphic short tandem repeat markers. The twins themselves responded to 8 questionnaire items, 4 items on twin similarity, and 4 items on the frequency of mistaking one twin for another by parents, relatives, teachers and strangers when they were 6 to 13 years old. Research assistants responded to 20 items regarding twins, physical features at the moment of interview. A parsimonious model established using stepwise logistic regression analysis of the 28 items showed that the total accuracy of zygosity diagnosis was 90.1%. The accuracy was 89.2% when using only the items dealing with the confusion of twins and 85.4% using only similarity. In the questionnaire, ′facial appearance′, ′mistaken by teachers′ and ′mistaken by strangers′ had stronger discriminating power between MZ and DZ twins. Two physical features - ′eyelid′ and ′middigital hair′ - were informative to some extent. There was no statistically significant sex and area difference in the validity of such questionnaire and physical features comparison-based classification. In conclusion, questionnaire-based zygosity assessment in this Chinese adult twin sample could still be regarded as a valid and valuable classification method. Physical features comparison, however, could only provide limited information for zygosity determination.

语种: 英语
WOS记录号: WOS:000237103200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62913
Appears in Collections:北京大学公共卫生学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100083, Peoples R China
2.Ctr Dis Control & Prevent, Qingdao, Peoples R China
3.Ctr Dis Control & Prevent, Lishui, Peoples R China

Recommended Citation:
Gao, WJ,Li, LM,Cao, WH,et al. Determination of zygosity by questionnaire and physical features comparison in Chinese adult twins[J]. TWIN RESEARCH AND HUMAN GENETICS,2006,9(2):266-271.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, WJ]'s Articles
[Li, LM]'s Articles
[Cao, WH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, WJ]‘s Articles
[Li, LM]‘s Articles
[Cao, WH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace