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学科主题: 基础医学
题名:
mTOR and S6K Play an Important Role in Ageing
作者: Zhu Feng; Ma Li-Wei; Tong Tan-Jun
关键词: mammalian target of rapamycin (mTOR) ; ribosomal protein S6 kinase (S6K) ; ageing
刊名: PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
发表日期: 2014-05-01
DOI: 10.3724/SP.J.1206.2013.00295
卷: 41, 期:5, 页:443-448
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: EXTENDS LIFE-SPAN ; TUBEROUS SCLEROSIS ; DIETARY RESTRICTION ; MAMMALIAN TARGET ; PHOSPHORYLATION ; KINASE ; GROWTH ; PATHWAY ; COMPLEX ; INHIBITION
英文摘要:

Aging process is modulated by various genes and signaling pathways. Mammalian target of rapamycin (mTOR) and ribosomal protein S6 kinase (S6K) not only regulate the physiological functions of cells, but also play an important role in the ageing progression. Recent study showed that inhibiting mTORC1 or S6K can extend the life span of mice. mTOR signaling influences ageing through various ways, including cell autophagy, metabolic by-products accumulation and affects the number of stem cells in tissues. However, the role of S6K in the ageing process remains unclear yet. Studies on the role of these two molecules in the ageing process, which have become a hotspot, are expected to find the method to extend the life span of mammalian and reveal its mechanisms. This review will focus on the role of mTOR and S6K in ageing.

语种: 中文
所属项目编号: YETP0057 ; 2013CB530801
项目资助者: Beijing Higher Education Young Elite Teacher Project ; National Basic Research Programs of China
WOS记录号: WOS:000336421100004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62919
Appears in Collections:基础医学院_期刊论文

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作者单位: Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Res Ctr Aging,Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Zhu Feng,Ma Li-Wei,Tong Tan-Jun. mTOR and S6K Play an Important Role in Ageing[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2014,41(5):443-448.
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