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Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV
Li, Fei1,2; Yang, Xiu-Wei1,2
关键词dehydrodiisoeugenol Myristica fragrans Houtt HPLC-UV
刊名BIOMEDICAL CHROMATOGRAPHY
2012-06-01
DOI10.1002/bmc.1717
26期:6页:703-707
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biochemistry & Molecular Biology ; Chemistry, Analytical ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Chemistry ; Pharmacology & Pharmacy
关键词[WOS]MYRISTICA-FRAGRANS ; IN-VITRO ; NEOLIGNANS ; MACE
英文摘要

Dehydrodiisoeugenol (DDIE) is a lignan in the fruit of Myristica fragrans. It can be converted into several metabolites in in vitro and in vivo metabolism. In this study, the excretion of DDIE in urine and feces was investigated after intravenous (i.v.) and intragastric (i.g.) administration to rats. DDIE and its metabolites (M-1 and M-2) were measured using HPLC. The amount of DDIE and its metabolites excreted was higher in feces than in urine, suggesting that DDIE and its metabolites are eliminated primarily in the feces. Significant differences in the excretion levels of DDIE and its metabolites were seen between i.v. and i.g. administration. Greater amounts of DDIE and its metabolites were excreted following i.v. administration, suggesting that DDIE can exert a longer period of anti-inflammatory activity following i.g. administration. The accuracy, precision, recovery and stability of the analytical method in this study were satisfactory for the measurement of DDIE and its metabolites in rat urine and feces. Observations made in this study will contribute to understanding of the absorption, distribution, metabolism and excretion pathway of DDIE and will aid decision-making regarding the best mode of DDIE administration during treatment to maximize its anti-inflammatory effects. Copyright (C) 2011 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000303438600005
项目编号30973863 ; 2002AA2Z343C ; 2004AA2Z3783 ; 2006BAI06A01-02 ; 2009ZX09301-010 ; Z0004105040311
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; &prime ; Major New Medicine Project&prime ; in Mega-projects of Science Research of China ; Beijing Municipal Special-purpose Science Foundation of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62920
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Fei,Yang, Xiu-Wei. Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV[J]. BIOMEDICAL CHROMATOGRAPHY,2012,26(6):703-707.
APA Li, Fei,&Yang, Xiu-Wei.(2012).Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV.BIOMEDICAL CHROMATOGRAPHY,26(6),703-707.
MLA Li, Fei,et al."Analysis of anti-inflammatory dehydrodiisoeugenol and metabolites excreted in rat feces and urine using HPLC-UV".BIOMEDICAL CHROMATOGRAPHY 26.6(2012):703-707.
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