IR@PKUHSC  > 北京大学临床肿瘤学院  > 遗传学研究室
学科主题临床医学
Seroprevalence of Merkel Cell Polyomavirus in the General Rural Population of Anyang, China
Zhang, Chanyuan1; Liu, Fangfang1; He, Zhonghu1; Deng, Qiuju1; Pan, Yaqi1; Liu, Ying1; Zhang, Chaoting1; Ning, Tao1; Guo, Chuanhai1; Liang, Yongmei1; Xu, Ruiping2; Zhang, Lixin2; Cai, Hong1; Ke, Yang1
刊名PLOS ONE
2014-09-03
DOI10.1371/journal.pone.0106430
9期:9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]GLUTATHIONE-S-TRANSFERASE ; CARCINOMA ; ANTIBODIES ; INFECTION ; JC ; BK ; PROTEINS ; SEROLOGY ; VIRUS ; ELISA
英文摘要

Background: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China.

Methods: Serum antibodies against MCPyV were evaluated by multiplex serology in a population-based study of 5548 adults (including 1587 heterosexual couples) aged 25-65 years who were enrolled from rural Anyang, China in 2007-2009. Univariate and multivariate logistic regression analyses were performed to assess the risk factors for the seropositivity of MCPyV.

Results: The seroprevalence for MCPyV was 61.0%. MCPyV seropositivity was significantly higher in males than in females (64.5% vs. 57.7%, P < 0.001), and for both genders, showed a trend of increase with age (Male: P-trend < 0.001; Female: P-trend < 0.001). Furthermore, among antibody positives, antibody levels of MCPyV increased with advancing age (P-trend = 0.017). MCPyV seropositivity of one spouse was significantly associated with that of the other partner (Adjusted OR = 1.32, 95% CI: 1.07-1.62). However, there was no association between sexual behaviors and the seropositivity of MCPyV.

Conclusions: High seroprevalence of MCPyV was observed in healthy Chinese individuals. Serological evidence suggests that nonsexual horizontal spread of MCPyV can occur among family members, and further research in this regard is needed.

语种英语
WOS记录号WOS:000341257700070
项目编号30872937 ; 30930102 ; 2011CB504300 ; 2012CB910800 ; 2006AA2Z467 ; 201202014 ; 200902002 ; 7100001
资助机构Natural Science Foundation of China ; "973" Project of National Ministry of Science and Technology Grant ; "863" Key Projects of National Ministry of Science and Technology Grant ; Charity Project of National Ministry of Health ; Natural Science Foundation of Beijing
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62923
专题北京大学临床肿瘤学院_遗传学研究室
北京大学第二临床医学院_病理科
作者单位1.Peking Univ, Canc Hosp & Inst, Genet Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Anyang Canc Hosp, Anyang, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Chanyuan,Liu, Fangfang,He, Zhonghu,et al. Seroprevalence of Merkel Cell Polyomavirus in the General Rural Population of Anyang, China[J]. PLOS ONE,2014,9(9).
APA Zhang, Chanyuan.,Liu, Fangfang.,He, Zhonghu.,Deng, Qiuju.,Pan, Yaqi.,...&Ke, Yang.(2014).Seroprevalence of Merkel Cell Polyomavirus in the General Rural Population of Anyang, China.PLOS ONE,9(9).
MLA Zhang, Chanyuan,et al."Seroprevalence of Merkel Cell Polyomavirus in the General Rural Population of Anyang, China".PLOS ONE 9.9(2014).
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