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学科主题: 临床医学
题名:
Seroprevalence of Merkel Cell Polyomavirus in the General Rural Population of Anyang, China
作者: Zhang, Chanyuan1; Liu, Fangfang1; He, Zhonghu1; Deng, Qiuju1; Pan, Yaqi1; Liu, Ying1; Zhang, Chaoting1; Ning, Tao1; Guo, Chuanhai1; Liang, Yongmei1; Xu, Ruiping2; Zhang, Lixin2; Cai, Hong1; Ke, Yang1
刊名: PLOS ONE
发表日期: 2014-09-03
DOI: 10.1371/journal.pone.0106430
卷: 9, 期:9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: GLUTATHIONE-S-TRANSFERASE ; CARCINOMA ; ANTIBODIES ; INFECTION ; JC ; BK ; PROTEINS ; SEROLOGY ; VIRUS ; ELISA
英文摘要:

Background: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China.

Methods: Serum antibodies against MCPyV were evaluated by multiplex serology in a population-based study of 5548 adults (including 1587 heterosexual couples) aged 25-65 years who were enrolled from rural Anyang, China in 2007-2009. Univariate and multivariate logistic regression analyses were performed to assess the risk factors for the seropositivity of MCPyV.

Results: The seroprevalence for MCPyV was 61.0%. MCPyV seropositivity was significantly higher in males than in females (64.5% vs. 57.7%, P < 0.001), and for both genders, showed a trend of increase with age (Male: P-trend < 0.001; Female: P-trend < 0.001). Furthermore, among antibody positives, antibody levels of MCPyV increased with advancing age (P-trend = 0.017). MCPyV seropositivity of one spouse was significantly associated with that of the other partner (Adjusted OR = 1.32, 95% CI: 1.07-1.62). However, there was no association between sexual behaviors and the seropositivity of MCPyV.

Conclusions: High seroprevalence of MCPyV was observed in healthy Chinese individuals. Serological evidence suggests that nonsexual horizontal spread of MCPyV can occur among family members, and further research in this regard is needed.

语种: 英语
所属项目编号: 30872937 ; 30930102 ; 2011CB504300 ; 2012CB910800 ; 2006AA2Z467 ; 201202014 ; 200902002 ; 7100001
项目资助者: Natural Science Foundation of China ; "973" Project of National Ministry of Science and Technology Grant ; "863" Key Projects of National Ministry of Science and Technology Grant ; Charity Project of National Ministry of Health ; Natural Science Foundation of Beijing
WOS记录号: WOS:000341257700070
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62923
Appears in Collections:北京大学临床肿瘤学院_遗传学研究室_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Genet Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Anyang Canc Hosp, Anyang, Peoples R China

Recommended Citation:
Zhang, Chanyuan,Liu, Fangfang,He, Zhonghu,et al. Seroprevalence of Merkel Cell Polyomavirus in the General Rural Population of Anyang, China[J]. PLOS ONE,2014,9(9).
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