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学科主题: 药学
题名:
Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis
作者: Zeng, HH; Tu, PF; Zhou, K; Wang, H; Wang, BH; Lu, JF
关键词: antioxidants ; LDL lipoproteins ; free radicals ; carnosol
刊名: ACTA PHARMACOLOGICA SINICA
发表日期: 2001-12-01
卷: 22, 期:12, 页:1094-1098
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: LIPID-PEROXIDATION ; ROSEMARY ; LDL ; ATHEROSCLEROSIS ; LIPOPROTEIN ; INHIBITION ; GENERATION ; OXIDATION ; RECEPTOR
英文摘要:

AIM: To investigate the inhibition capacities of carnosol, rosmanol, and epirosmanol, which are phenolic diterpenes from Rosmarinus officinalis, to oxidized low-density lipoprotein (LDL) formation in human blood and detect their scavenging activities to lipid free radical and superoxide anion in vitro. METHODS: The antioxidant activities which were expressed with the inhibilities to lipid free radicals in the membrane lipid of cell and oxidized LDL formation were evaluated by TBARS assay and ESR method. The inhibition on the Cu2+-mediated oxidization of apo B formation in LDL was investigated by fluorescence spectroscopy. RESULTS: Carnosol, rosmanol, and epirosmanol had an inhibitory activity to lipid peroxidation and oxidized apo B formation in human bloods LDL. The IC50 were 7-10 mu mol/L. The antioxidant mechanism was related to the scavenging activities to lipid free radical. CONCLUSION: carnosol, rosmanol, and epirosmanol. showed the activity in inhibiting LDL oxidation.

语种: 英语
WOS记录号: WOS:000172725000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62924
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Peking Univ, Inst Chem Phys, Beijing 100087, Peoples R China

Recommended Citation:
Zeng, HH,Tu, PF,Zhou, K,et al. Antioxidant properties of phenolic diterpenes from Rosmarinus officinalis[J]. ACTA PHARMACOLOGICA SINICA,2001,22(12):1094-1098.
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