IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Predictive value of the serum level of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in left ventricular remodeling after acute myocardial infarction
Hu, XZ; Zhang, J; Li, ZR; Cui, LY
关键词N-terminal pro-brain natriuretic peptide (NT-proBNP) high-sensitivity C-reactive protein (hs-CRP) acute myocardial infarction (AMI) left ventricular remodeling echocardiography ROC curve
刊名JOURNAL OF CLINICAL LABORATORY ANALYSIS
2006
DOI10.1002/jcla.20094
20期:1页:19-22
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medical Laboratory Technology
研究领域[WOS]Medical Laboratory Technology
关键词[WOS]MARKER
英文摘要

This study was designed to measure the correlation between left ventricular (LV) remodeling 3 months after successful reperfusion therapy, and the levels of serum N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity C-reactive protein (hs-CRP) at 3 days after acute myocardial infarction (AMI), and to determine the predictive levels of NT-proBNP and hs-CRP for LV remodeling. A total of 106 patients with first AMI were included in this study. Each patient was examined by echocardiography (ECG) on the third day and third month after AM], and LV remodeling was determined by the difference in the LEV end-diastolic volume (LVEDV) between the third day and the third month. Serum NT-proBNP and hs-CRP level were measured 3 days after AMI. Then the correlation between the 3-months change in LVEDV and the levels of serum NT-proBNP or hs-CRP was determined. In addition, sensitivity and specificity were calculated with a receiver operating characteristic (ROC) curve to identify correspondence with LV remodeling (defined as the change rate of LVEDV >20%). Our results showed that the correlation coefficients with the change of LVEDV were 0.706 for serum NT-pro BNP (P<0.001) and 0.596 for hs-CRP (P<0.05). With a cutoff value of 0.2, the area under the ROC curve (AUC) was 0.894 for NT-proBNP and 0.825 for hs-CRP. Although the AUC did not statistically differ between NT-proBNP and hs-CRP, NT-proBNP is more effective than serum hs-CRP as a marker to predict LV remodeling.

语种英语
WOS记录号WOS:000236553800004
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62928
Collection北京大学第三临床医学院
作者单位Peking Univ, Hosp 3, Dept Lab Med, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Hu, XZ,Zhang, J,Li, ZR,et al. Predictive value of the serum level of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in left ventricular remodeling after acute myocardial infarction[J]. JOURNAL OF CLINICAL LABORATORY ANALYSIS,2006,20(1):19-22.
APA Hu, XZ,Zhang, J,Li, ZR,&Cui, LY.(2006).Predictive value of the serum level of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in left ventricular remodeling after acute myocardial infarction.JOURNAL OF CLINICAL LABORATORY ANALYSIS,20(1),19-22.
MLA Hu, XZ,et al."Predictive value of the serum level of N-terminal pro-brain natriuretic peptide and high-sensitivity C-reactive protein in left ventricular remodeling after acute myocardial infarction".JOURNAL OF CLINICAL LABORATORY ANALYSIS 20.1(2006):19-22.
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