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Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes
Liu, Y; Lu, WL; Zhang, X; Wang, XQ; Zhang, H; Zhang, Q
关键词absorption recombinant hirudin non-parenteral route pharmacodynamics pharmacokinetics
刊名PEPTIDES
2005-03-01
DOI10.1016/j.peptides.2004.10.003
26期:3页:423-430
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]RECTAL ABSORPTION ; &lt ; ASU1,7&gt ; -EEL CALCITONIN ; DRUG-DELIVERY ; ALBINO RABBIT ; RATS ; INSULIN ; ENHANCEMENT ; TRACHEA
英文摘要

One of recombinant hirudin variants, rHV2, a polypeptide used as an anticoagulant agent in clinic, was administered to anesthetized rats via intratracheal, buccal, nasal and rectal routes. Prolongation in clotting time and thrombin time was measured to calculate pharmacological bioavailability. Plasma concentration of rHV2 was determined using a chromogenic thrombin substrate assay and pharmacokinetic parameters were obtained on the basis of a non-compartmental model. Intravenous administration was also performed as the gold standard by which the other routes were compared. Difference in pharmacological bioavailability (P.A.), bioavailability (F) and absorption rate of rHV2 was found for the four non-parenteral routes. The rank order for both P.A. and F was intratracheal > nasal > buccal > rectal. Absorption was more rapid after both intratracheal and rectal administration (t(max) similar to 20-40 min), compared with that after nasal and rectal administration. It is evident that the pulmonary route is preferable to other three routes for successful systemic delivery of rHV2. (C) 2004 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000226932900010
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62931
专题北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, Y,Lu, WL,Zhang, X,et al. Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes[J]. PEPTIDES,2005,26(3):423-430.
APA Liu, Y,Lu, WL,Zhang, X,Wang, XQ,Zhang, H,&Zhang, Q.(2005).Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes.PEPTIDES,26(3),423-430.
MLA Liu, Y,et al."Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes".PEPTIDES 26.3(2005):423-430.
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