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学科主题: 药学
题名:
Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes
作者: Liu, Y; Lu, WL; Zhang, X; Wang, XQ; Zhang, H; Zhang, Q
关键词: absorption ; recombinant hirudin ; non-parenteral route ; pharmacodynamics ; pharmacokinetics
刊名: PEPTIDES
发表日期: 2005-03-01
DOI: 10.1016/j.peptides.2004.10.003
卷: 26, 期:3, 页:423-430
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: RECTAL ABSORPTION ; &lt ; ASU1,7&gt ; -EEL CALCITONIN ; DRUG-DELIVERY ; ALBINO RABBIT ; RATS ; INSULIN ; ENHANCEMENT ; TRACHEA
英文摘要:

One of recombinant hirudin variants, rHV2, a polypeptide used as an anticoagulant agent in clinic, was administered to anesthetized rats via intratracheal, buccal, nasal and rectal routes. Prolongation in clotting time and thrombin time was measured to calculate pharmacological bioavailability. Plasma concentration of rHV2 was determined using a chromogenic thrombin substrate assay and pharmacokinetic parameters were obtained on the basis of a non-compartmental model. Intravenous administration was also performed as the gold standard by which the other routes were compared. Difference in pharmacological bioavailability (P.A.), bioavailability (F) and absorption rate of rHV2 was found for the four non-parenteral routes. The rank order for both P.A. and F was intratracheal > nasal > buccal > rectal. Absorption was more rapid after both intratracheal and rectal administration (t(max) similar to 20-40 min), compared with that after nasal and rectal administration. It is evident that the pulmonary route is preferable to other three routes for successful systemic delivery of rHV2. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000226932900010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62931
Appears in Collections:北京大学药学院_药剂学系_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China

Recommended Citation:
Liu, Y,Lu, WL,Zhang, X,et al. Pharmacodynamics and pharmacokinetics of recombinant hirudin via four non-parenteral routes[J]. PEPTIDES,2005,26(3):423-430.
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