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学科主题: 临床医学
题名:
Fourier transform mid-infrared spectroscopy (FTIR) used for the rapid intraoperative diagnosis of gallbladder diseases
作者: Xu Yi-Zhuang; Zhao Ying; Ling Xiao-Feng; Yang Li-Min; Xu Zhi; Zhou Xiao-Si; Zhang Yuan-Fu; Gong Rong-Ye; Pan Qing-Hua; Wang Bing-Bing; Shi Jing-Sen; Xu Duan-Fu; Wu Jin-Guang
关键词: FTIR ; mid-IR fiber optics ; gallbladder ; detection
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2007-04-10
卷: 28, 期:4, 页:645-648
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: IN-VIVO ; TUMOR
英文摘要:

Identification of gallbladder cancer rapidly at the time of surgery would allow the appropriate resection to be completed at the original surgery. The aim of this study was to assess the sensitivity and specificity of FTIR in the rapid detection of gallbladder cancer, via an attenuated total reflection( ATR ) accessory with a ZnSe window. This allowed the edges of the surgically resected specimens to be examined rapidly. The results indicate that there are a series of differences between the spectra of normal and malignant tissues, and subtraction technique is helpful to identify cholecystitis and gallbladder cancer. Compared with pathological diagnosis results, one benign specimen was classified as a malignant and 6/6 malignant specimens and 39 cases of benign specimens were correctly classified. The sensitivity was 100% ( 6/6 ), specificity 97% ( 39/40 ), and accuracy was 97% ( 45/46 ). We can conclude that mid-infrared ATR FTIR spectroscopy is highly accurate and rapidly allows appropriately tailored resection at the time of initial surgery.

语种: 中文
WOS记录号: WOS:000245874300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62934
Appears in Collections:北京大学第三临床医学院_普通外科_期刊论文

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作者单位: 1.Peking Univ, Dept Surg, Hosp 3, Beijing 100083, Peoples R China
2.Hangzhou Teachers Coll, Hangzhou 310015, Peoples R China
3.Second People Hosp Hangzhou, Hangzhou 310015, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, State Key Lab Rare Earth Mat & Applicat, Beijing 100871, Peoples R China
5.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
6.Beijing Rayleigh Analyt Instrument Corp, Beijing Opt Instrument Factory 2, Beijing 100015, Peoples R China
7.Xian Jiaotong Univ, Dept Surg Oncol, Hosp 1, Xian 710061, Peoples R China

Recommended Citation:
Xu Yi-Zhuang,Zhao Ying,Ling Xiao-Feng,et al. Fourier transform mid-infrared spectroscopy (FTIR) used for the rapid intraoperative diagnosis of gallbladder diseases[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2007,28(4):645-648.
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