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The Genetic Correlation Between Cigarette Smoking and Alcohol Drinking Among Chinese Adult Male Twins: An Ordinal Bivariate Genetic Analysis
Zhang, Ting1; Gao, Wenjing1; Cao, Weihua1; Zhan, Siyan1; Lv, Jun1; Pang, Zengchang2; Wang, Shaojie2; Chen, Rongfu3; Hu, Yonghua1; Li, Liming1
关键词Genetic correlation tobacco alcohol heritability male China
刊名TWIN RESEARCH AND HUMAN GENETICS
2012-08-01
DOI10.1017/thg.2012.31
15期:4页:483-490
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology
关键词[WOS]ENVIRONMENTAL CONTRIBUTIONS ; NICOTINE DEPENDENCE ; SUBSTANCE USE ; FEMALE TWINS ; YOUNG-ADULTS ; TOBACCO ; HERITABILITY ; ASSOCIATION ; ADOLESCENT ; REGISTRY
英文摘要

Background: Though multiple policies have been implemented, the cigarette control in China is still facing a great challenge. At the same time, alcohol drinking has increasingly become a public health problem. Considering cigarette smoking and alcohol drinking often co-occur, a few studies tested the covariance of these phenotypes. However, the genetic and environmental correlation between them among Chinese population has not been determined. The main aim of this study is to fill this gap. Methods: From the Chinese National Twin Registry, we obtained the data on cigarette smoking and alcohol drinking behaviors. The ordinal bivariate genetic analysis was performed to fit the categorical variables. After identifying the best decomposition among the Cholesky, common, and independent pathway model, we established the most parsimonious submodel. Results: The correlation between current tobacco and alcohol use could be explained by Cholesky model. The shared environmental variances for both phenotypes were dropped to construct the most parsimonious submodel. Furthermore, the most parsimonious submodel showed a moderate correlation (0.32, 95%CI = 0.17 0.46) between the genetic components and a negligible non-shared environmental correlation. Conclusion: As the first bivariate genetic analysis on current tobacco smoking and current alcohol drinking in China, this study suggested a common genetic vulnerability to tobacco and alcohol use in male twins. Further studies should be carried out to track the pertinent genes that are related to the comorbidity of smoking and drinking in Chinese population. Another urgent need is to recognize the behavior-specific environmental risk factors.

语种英语
WOS记录号WOS:000306253400002
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62945
Collection北京大学公共卫生学院
作者单位1.Ctr Dis Control & Prevent, Lishui, Peoples R China
2.Ctr Dis Control & Prevent, Qingdao, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ting,Gao, Wenjing,Cao, Weihua,et al. The Genetic Correlation Between Cigarette Smoking and Alcohol Drinking Among Chinese Adult Male Twins: An Ordinal Bivariate Genetic Analysis[J]. TWIN RESEARCH AND HUMAN GENETICS,2012,15(4):483-490.
APA Zhang, Ting.,Gao, Wenjing.,Cao, Weihua.,Zhan, Siyan.,Lv, Jun.,...&Li, Liming.(2012).The Genetic Correlation Between Cigarette Smoking and Alcohol Drinking Among Chinese Adult Male Twins: An Ordinal Bivariate Genetic Analysis.TWIN RESEARCH AND HUMAN GENETICS,15(4),483-490.
MLA Zhang, Ting,et al."The Genetic Correlation Between Cigarette Smoking and Alcohol Drinking Among Chinese Adult Male Twins: An Ordinal Bivariate Genetic Analysis".TWIN RESEARCH AND HUMAN GENETICS 15.4(2012):483-490.
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