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学科主题: 临床医学
题名:
The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules
作者: Xu, Liling1,3,5,6,7; Auzins, Arturs1,3; Sun, Xiaolin4; Xu, Yinsheng1,3; Harnischfeger, Fiona1; Lu, Yun2; Li, Zhanguo4; Chen, Ying-Hua1; Zheng, Wenjie5,6,7; Liu, Wanli1,3
刊名: JOURNAL OF LEUKOCYTE BIOLOGY
发表日期: 2015-08-01
DOI: 10.1189/jlb.2A0614-287RR
卷: 98, 期:2, 页:223-234
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Hematology ; Immunology
研究领域[WOS]: Cell Biology ; Hematology ; Immunology
关键词[WOS]: B-CELL RECEPTOR ; RESONANCE ENERGY-TRANSFER ; ANTIGEN RECEPTOR ; IMMUNE-SYNAPSE ; LYMPH-NODE ; SUBCAPSULAR SINUS ; CD19/CD21 COMPLEX ; LIVING CELLS ; T-CELLS ; ACTIVATION
英文摘要:

Sphingolipid-and cholesterol-rich lipid raft microdomains are important in the initiation of BCR signaling. Although it is known that lipid rafts promote the coclustering of BCR and Lyn kinase microclusters within the B cell IS, the molecular mechanism of the recruitment of lipid rafts into the B cell IS is not understood completely. Here, we report that the synaptic recruitment of lipid rafts is dependent on the cytoskeleton-remodeling proteins, RhoA and Vav. Such an event is also efficiently regulated by motor proteins, myosin IIA and dynein. Further evidence suggests the synaptic recruitment of lipid rafts is, by principle, an event triggered by BCR signaling molecules and second messenger molecules. BCR-activating coreceptor CD19 potently enhances such an event depending on its cytoplasmic Tyr421 and Tyr482 residues. The enhancing function of the CD19-PI3K module in synaptic recruitment of lipid rafts is also confirmed in human peripheral blood B cells. Thus, these results improve our understanding of the molecular mechanism of the recruitment of lipid raft microdomains in B cell IS.

语种: 英语
所属项目编号: 2014CB542500-03 ; 2014AA020527 ; 81361120384 ; 31270913 ; 81422020 ; 5132016 ; 20130002110059 ; 20131089279
项目资助者: Ministry of Science and Technology of China ; National Science Foundation China ; Beijing Natural Science Foundation ; Ph.D. Programs Foundation of Ministry of Education of China ; Tsinghua University Initiative Scientific Research Program ; Center for Life Sciences of Tsinghua University
WOS记录号: WOS:000357953700010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62948
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Collaborat Innovat Ctr Infect Dis, Hangzhou, Zhejiang, Peoples R China
2.Minist Educ, Key Lab Rheumatol & Clin Immunol, Beijing, Peoples R China
3.Tsinghua Univ, Sch Life Sci, MOE Key Lab Prot Sci, Beijing 100084, Peoples R China
4.Tsinghua Univ, Sch Environm, State Key Joint Lab Environm Simulat & Pollut Con, Beijing 100084, Peoples R China
5.Peking Univ, Peoples Hosp, Clin Immunol Ctr, Dept Rheumatol & Immunol, Beijing 100871, Peoples R China
6.Peking Union Med Coll, Peking Union Med Coll Hosp, Dept Rheumatol & Clin Immunol, Beijing 100021, Peoples R China
7.Chinese Acad Med Sci, Beijing 100730, Peoples R China

Recommended Citation:
Xu, Liling,Auzins, Arturs,Sun, Xiaolin,et al. The synaptic recruitment of lipid rafts is dependent on CD19-PI3K module and cytoskeleton remodeling molecules[J]. JOURNAL OF LEUKOCYTE BIOLOGY,2015,98(2):223-234.
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