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学科主题: 药学
题名:
A pair of unprecedented spiro-trisindole enantiomers fused through a five-member ring from Laurencia similis
作者: Sun, Wen-Shuang1,2; Su, Shan1,2; Zhu, Rong-Xiu3; Tu, Guang-Zhong4; Cheng, Wei1,2; Liang, Hong1,2; Guo, Xiao-Yu1,2; Zhao, Yu-Ying1,2; Zhang, Qing-Ying1,2
关键词: Laurencia similis ; Spiro-trisindole enantiomer ; Similisine A ; Similisine B
刊名: TETRAHEDRON LETTERS
发表日期: 2013-07-10
DOI: 10.1016/j.tetlet.2013.04.111
卷: 54, 期:28, 页:3617-3620
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: TRIS-INDOLE ALKALOIDS ; RED ALGA ; ARISTOLANE SESQUITERPENES ; BROMINATED METABOLITES ; DEEP-WATER ; ORINA SP ; RHODOMELACEAE ; BIS
英文摘要:

Similisines A (1a) and B (1b), a pair of unprecedented polybrominated spiro-trisindole enantiomers fused through a five-member ring, along with seven known biologically related indole alkaloids, were isolated from Laurencia similis. The structures and absolute configurations of the enantiomers were elucidated by comprehensive spectroscopic analysis, computer modeling, and comparison of experimental and theoretically calculated ECD. The proposed biogenetic pathway of 1a and 1b and cytotoxic activity of all isolates were also discussed. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 21172008
项目资助者: National Natural Science Foundation of China ; Union Opening Foundation of CAS&prime ; Key Laboratory of Marine Bio-resources Sustainable Utilization (LMB) ; Union Opening Foundation of CAS&prime ; Guangdong Key Laboratory of Marine Materia Medica (LMM)
WOS记录号: WOS:000320689000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62953
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
3.Shandong Univ, Sch Chem & Chem Engn, Jinan 250100, Peoples R China
4.Beijing Inst Microchem, Beijing 100091, Peoples R China

Recommended Citation:
Sun, Wen-Shuang,Su, Shan,Zhu, Rong-Xiu,et al. A pair of unprecedented spiro-trisindole enantiomers fused through a five-member ring from Laurencia similis[J]. TETRAHEDRON LETTERS,2013,54(28):3617-3620.
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