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学科主题: 临床医学
题名:
A novel approach to generate host antitumor T cells: Adoptive immunotherapy by T cells maturing in xenogeneic thymus
作者: Zhao, Yong; Sun, Yimin; Niu, Zeqing; Li, Qinghuan; Peng, Jianxiao; Wang, Junjie; Langnas, Alan N.
关键词: transplantation ; immune response ; tumor immunity ; adoptive immunotherapy ; and melanoma
刊名: JOURNAL OF IMMUNOTHERAPY
发表日期: 2007
卷: 30, 期:1, 页:83-88
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology ; Medicine, Research & Experimental
研究领域[WOS]: Oncology ; Immunology ; Research & Experimental Medicine
关键词[WOS]: SKIN-GRAFT TOLERANCE ; FETAL PIG THYMUS ; THYMECTOMIZED MICE ; CELLULAR IMMUNOTHERAPY ; MELANOMA-CELLS ; IN-VITRO ; CANCER ; INDUCTION ; CD4(+) ; LYMPHOCYTES
英文摘要:

Mouse or human T cells developing in xenogeneic porcine thymus are functional. With efficient peripheral repopulation of mouse T cells by grafting fetal pig thymus (FP THY), B6 nude mice were immunized with inactivated syngeneic melanoma, B16 cells. Splenocytes from B16-immunized FP THY-grafted B6 nude mice efficiently killed B16, but not EL4 target cells in cytotoxicity assays in vitro. Adoptive transfer of splenocytes from B16-immunizd FP THY-grafted B6 nude mice to B16-bearing B6 mice significantly prolonged recipient survival and inhibited B16 solid tumor growth when B16 cells were injected IV or SC, respectively, compared with the identical controls. Splenocytes from nonimmunized FP THY-grafted B6 nude mice failed to protect B6 mice from B16-induced mortality. The present data have demonstrated that mouse T cells maturing in xenogeneic thymus have the ability to kill syngeneic tumor cells. This study may offer a novel resource to produce host antitumor T cells for adoptive immunotherapy of tumor patients.

语种: 英语
WOS记录号: WOS:000243091400008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62957
Appears in Collections:北京大学临床肿瘤学院_肿瘤放疗科_期刊论文

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作者单位: 1.Chinese Acad Sci, Inst Zool, Translat Biol Res Div, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100080, Peoples R China
2.Peking Univ, Hosp 2, Dept Radiat Oncol, Beijing 100871, Peoples R China
3.Univ Nebraska, Med Ctr, Dept Surg, Lied Transplant Ctr, Omaha, NE 68182 USA

Recommended Citation:
Zhao, Yong,Sun, Yimin,Niu, Zeqing,et al. A novel approach to generate host antitumor T cells: Adoptive immunotherapy by T cells maturing in xenogeneic thymus[J]. JOURNAL OF IMMUNOTHERAPY,2007,30(1):83-88.
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