IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit
Chen, M; Huo, Y; Liu, ZP; Wang, RS; Zhu, GY
关键词angioplasty restenosis endovascular irradiation
刊名CHINESE MEDICAL JOURNAL
2001
114期:1页:62-63
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
英文摘要

Objective To examine the effect of endovascular irradiation on restenosis after balloon angioplasty in rabbit.

Methods After the establishment of rabbit iliac atherosclerosis model, balloon angioplasty was performed at the lesion segment of the iliac artery. Rabbits were randomly divided into three groups: control group, 10 Gy irradiated group and 18 Gy irradiated group. Endovascular irradiation was performed for irradiated groups at the dilated sites by introducing the Ir-192 radioactive guidewire through a catheter. After four weeks, the animals were killed and the target segments were cut down. Histopathologic and morphometric analyses were carried out.

Results The mean final lumen area in the 18 Gy group was larger than that in the control or 10 Gy group (P < 0.05). The intimal area in the 18 Gy group was smaller ( P < 0.05).

Conclusions Ir-192 endovascular irradiation may prevent restenosis after balloon angioplasty. The effect is related to the delivered dose. The mechanism is involved in inhibition of neointimal proliferation.

语种英语
WOS记录号WOS:000167246600013
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62961
Collection北京大学第一临床医学院_心血管内科
作者单位Peking Univ First Hosp, Dept Cardiol, Beijing 100034, Peoples R China
Recommended Citation
GB/T 7714
Chen, M,Huo, Y,Liu, ZP,et al. Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit[J]. CHINESE MEDICAL JOURNAL,2001,114(1):62-63.
APA Chen, M,Huo, Y,Liu, ZP,Wang, RS,&Zhu, GY.(2001).Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit.CHINESE MEDICAL JOURNAL,114(1),62-63.
MLA Chen, M,et al."Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit".CHINESE MEDICAL JOURNAL 114.1(2001):62-63.
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