|Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit|
|Chen, M; Huo, Y; Liu, ZP; Wang, RS; Zhu, GY|
|关键词||angioplasty restenosis endovascular irradiation|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
Objective To examine the effect of endovascular irradiation on restenosis after balloon angioplasty in rabbit.
Methods After the establishment of rabbit iliac atherosclerosis model, balloon angioplasty was performed at the lesion segment of the iliac artery. Rabbits were randomly divided into three groups: control group, 10 Gy irradiated group and 18 Gy irradiated group. Endovascular irradiation was performed for irradiated groups at the dilated sites by introducing the Ir-192 radioactive guidewire through a catheter. After four weeks, the animals were killed and the target segments were cut down. Histopathologic and morphometric analyses were carried out.
Results The mean final lumen area in the 18 Gy group was larger than that in the control or 10 Gy group (P < 0.05). The intimal area in the 18 Gy group was smaller ( P < 0.05).
Conclusions Ir-192 endovascular irradiation may prevent restenosis after balloon angioplasty. The effect is related to the delivered dose. The mechanism is involved in inhibition of neointimal proliferation.
|作者单位||Peking Univ First Hosp, Dept Cardiol, Beijing 100034, Peoples R China|
|Chen, M,Huo, Y,Liu, ZP,et al. Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit[J]. CHINESE MEDICAL JOURNAL,2001,114(1):62-63.|
|APA||Chen, M,Huo, Y,Liu, ZP,Wang, RS,&Zhu, GY.(2001).Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit.CHINESE MEDICAL JOURNAL,114(1),62-63.|
|MLA||Chen, M,et al."Ir-192 endovascular irradiation prevents restenosis after balloon angioplasty in rabbit".CHINESE MEDICAL JOURNAL 114.1(2001):62-63.|