IR@PKUHSC  > 北京大学第二临床医学院  > 心血管内科
学科主题临床医学
In vitro anticoagulation monitoring of low-molecular-weight heparin
Wang Jian-qi2; Shi Xu-bo2; Yang Jin-gang3,4,5; Hu Da-yi1
关键词activated clotting time low-molecular-weight heparin anticoagulation monitoring anti-Xa factor
刊名CHINESE MEDICAL JOURNAL
2009-05-20
DOI10.3760/cma.j.issn.0366-6999.2009.10.016
122期:10页:1199-1202
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]ACUTE CORONARY SYNDROMES ; HIGH-RISK PATIENTS ; UNFRACTIONATED HEPARIN ; ENOXAPARIN ; TRIAL ; INHIBITORS ; EFFICACY ; STRATEGY ; THERAPY ; SAFETY
英文摘要

Background Although low-molecular-weight heparin has replaced unfractionated heparin to become the primary anticoagulation drug for treatment of acute coronary syndrome, there is no convenient bedside monitoring method. We explored the best laboratory monitoring method of low-molecular-weight heparins (enoxaparin, dalteparin, and nadroparin) by use of the Sonoclot coagulation analyzer to monitor the activated clotting time.

Methods A total of 20 healthy volunteers were selected and 15 ml of fasting venous blood samples were collected and incubated. Four coagulants, kaolin, diatomite, glass bead, and magnetic stick, were used to determine the activated clotting time of the low-molecular-weight heparins at different in vitro anti-Xa factor concentrations. A correlation analysis was made to obtain the regression equation. The activated clotting time of the different low-molecular-weight heparins with the same anti-Xa factor concentration was monitored when the coagulant glass beads were applied.

Results The activated clotting time measured using the glass beads, diatomite, kaolin, and magnetic stick showed a linear correlation with the concentration of nadroparin (r = 0.964, 0.966, 0.970, and 0.947, respectively). The regression equation showed that the linear slopes of different coagulants were significantly different (glass beads 230.03 s/IU, diatomite 89.91 s/IU, kaolin 50.87 s/IU, magnetic stick could not be calculated). When the concentration of the anti-Xa factor was the same for different low-molecular-weight heparins, the measured activated clotting time was different after the application of the glass bead coagulant.

Conclusions The glass bead coagulant is most feasible for monitoring the in vitro anticoagulation activity of nadroparin. The different effects of different low-molecular-weight heparins on the activated clotting time may be related to the different anti-Ila activities. Chin Med J 2009;122(10):1199-1202

语种英语
WOS记录号WOS:000266383000016
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62966
专题北京大学第二临床医学院_心血管内科
作者单位1.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
2.Capital Med Univ, Beijing Tongren Hosp, Dept Cardiovasc Ctr, Beijing 100730, Peoples R China
3.Chinese Acad Med Sci, Dept Cardiol, Cardiovasc Inst, Beijing 100037, Peoples R China
4.Chinese Acad Med Sci, Fu Wai Hosp, Beijing 100037, Peoples R China
5.Peking Union Med Coll, Beijing 100037, Peoples R China
推荐引用方式
GB/T 7714
Wang Jian-qi,Shi Xu-bo,Yang Jin-gang,et al. In vitro anticoagulation monitoring of low-molecular-weight heparin[J]. CHINESE MEDICAL JOURNAL,2009,122(10):1199-1202.
APA Wang Jian-qi,Shi Xu-bo,Yang Jin-gang,&Hu Da-yi.(2009).In vitro anticoagulation monitoring of low-molecular-weight heparin.CHINESE MEDICAL JOURNAL,122(10),1199-1202.
MLA Wang Jian-qi,et al."In vitro anticoagulation monitoring of low-molecular-weight heparin".CHINESE MEDICAL JOURNAL 122.10(2009):1199-1202.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang Jian-qi]的文章
[Shi Xu-bo]的文章
[Yang Jin-gang]的文章
百度学术
百度学术中相似的文章
[Wang Jian-qi]的文章
[Shi Xu-bo]的文章
[Yang Jin-gang]的文章
必应学术
必应学术中相似的文章
[Wang Jian-qi]的文章
[Shi Xu-bo]的文章
[Yang Jin-gang]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。