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学科主题: 临床医学
题名:
Systematic Review and Meta-Analysis of the Association Between Complement Component 3 and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis
作者: Thakkinstian, Ammarin1; McKay, Gareth J.2; McEvoy, Mark4; Chakravarthy, Usha3; Chakrabarti, Subhabrata5; Silvestri, Giuliana3; Kaur, Inderjeet5; Li, Xiaoxin6,7; Attia, John4,8,9
关键词: complement component factor 3 ; epidemiology ; genetic association studies ; genetics ; macular degeneration ; meta-analysis
刊名: AMERICAN JOURNAL OF EPIDEMIOLOGY
发表日期: 2011-06-15
DOI: 10.1093/aje/kwr025
卷: 173, 期:12, 页:1365-1379
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Public, Environmental & Occupational Health
研究领域[WOS]: Public, Environmental & Occupational Health
关键词[WOS]: FACTOR-B BF ; FACTOR-H ; MOLECULAR ASSOCIATION ; CHINESE POPULATION ; PUBLICATION BIAS ; LOC387715 GENES ; FUNNEL PLOTS ; RISK-FACTOR ; 2 C2 ; C3
英文摘要:

The authors performed a meta-analysis to estimate the magnitude of polymorphism effects for the complement component C3 gene (C3) and their possible mode of action on age-related macular degeneration (AMD). The meta-analysis included 16 and 7 studies for rs2230199 and rs1047286, respectively. Data extraction and risk of bias assessments were performed in duplicate, and heterogeneity and publication bias were explored. There was moderate evidence for association between both polymorphisms and AMD in Caucasians. For rs2230199, patients with CG and GG genotypes were 1.44 (95% confidence interval (CI): 1.33, 1.56) and 1.88 (95% CI: 1.59, 2.23) times more likely to have AMD than patients with the CC genotype. For rs1047286, GA and AA genotypes had 1.27 (95% CI: 1.15, 1.41) and 1.70 (95% CI: 1.27, 2.11) times higher risk of AMD than did GG genotypes. These gene effects suggested an additive model. The population attributable risks for the GG/GC and AA/GA genotypes are approximately 5%-10%. Subgroup analysis by ethnicity indicates that these variants are very infrequent in Asians and that the observed gene effects are based largely on the high frequency within Caucasian populations. This meta-analysis supports the association between C3 and AMD and provides a robust estimate of the genetic risk.

语种: 英语
WOS记录号: WOS:000291488700003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62970
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Mahidol Univ, Ramathibodi Hosp, Fac Med, Sect Clin Epidemiol & Biostat, Bangkok 10400, Thailand
2.Queens Univ Belfast, Ctr Publ Hlth, Belfast, Antrim, North Ireland
3.Queens Univ Belfast, Ctr Vision & Vasc Sci, Belfast, Antrim, North Ireland
4.Univ Newcastle, Ctr Clin Epidemiol & Biostat, Newcastle, NSW 2300, Australia
5.LV Prasad Eye Inst, Brien Holden Eye Res Ctr, Hyderabad, Andhra Pradesh, India
6.Peking Univ, Peoples Hosp, Peoples Eye Ctr, Beijing 100871, Peoples R China
7.Peking Univ, Peoples Hosp, Inst Eye, Beijing 100871, Peoples R China
8.Hunter Med Res Inst, Newcastle, NSW, Australia
9.John Hunter Hosp, Dept Gen Med, Newcastle, NSW, Australia

Recommended Citation:
Thakkinstian, Ammarin,McKay, Gareth J.,McEvoy, Mark,et al. Systematic Review and Meta-Analysis of the Association Between Complement Component 3 and Age-related Macular Degeneration: A HuGE Review and Meta-Analysis[J]. AMERICAN JOURNAL OF EPIDEMIOLOGY,2011,173(12):1365-1379.
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