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Individualized Intervention Guided by BCR-ABL Transcript Levels after HLA-Identical Sibling Donor Transplantation Improves HSCT Outcomes for Patients with Chronic Myeloid Leukemia
Huang, Xiao-Jun; Xu, Lan-Ping; Liu, Kai-Yan; Liu, Dai-Hong; Chen, Huan; Liu, Yan-Rong; Chen, Yu-Hong; Han, Wei; Wang, Yu
关键词HLA-matched Blood and marrow transplantation Chronic myeloid leukemia BCR-ABL
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2011-05-01
DOI10.1016/j.bbmt.2010.07.023
17期:5页:649-656
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; REDUCED-INTENSITY TRANSPLANTATION ; COMPLETE CYTOGENETIC RESPONSE ; CHRONIC MYELOGENOUS LEUKEMIA ; TERM-FOLLOW-UP ; LYMPHOCYTE INFUSION ; IMATINIB MESYLATE ; WORKING PARTY ; RELAPSE ; CML
英文摘要

The aim of this study was to determine the effect of individualized intervention guided by BCR-ABL transcript levels after hematopoietic stem cell transplantation (HSCT) on relapse and leukemia-free survival (LFS) of patients with chronic myelogenous leukemia (CML). Eighty-four consecutive patients who received HLA-identical sibling HSCT were enrolled. The patients were conditioned with a modified busulfan and cyclophosphamide regimen, and received stem cells from a HLA-identical sibling donor. Patients were identified as high risk of relapse based on serial monitoring of post-HSCT BCR-ABL transcript levels, and patients in the high-risk group were given individualized intervention. Interventions included immunosuppressant withdrawal, modified donor lymphocyte infusion, and imatinib mesylate. Engraftment was successful in all patients. Twenty-eight patients were categorized as high risk because of higher post-HSCT BCR-ABL transcript levels and received intervention. The 56 low-risk patients received no intervention. Twenty-five high-risk patients achieved complete molecular remission at a median of 49 days (range: 18-232 days) after intervention. Two high-risk patients and 1 low-risk patient ultimately relapsed, the 4-year relapse rate was 3.9% +/- 4.4%. Overall 4-year survival was 89.0% +/- 7% and the 4-year LFS was 89.2% +/- 6.8%. All surviving patients remains in complete molecular remission after a median of 1481(1040-1794) days follow-up. Individualized intervention based on the post-HSCT BCR-ABL transcript level can decrease relapse and increase LFS of patients with CML after HLA-identical sibling HSCT. Biol Blood Marrow Transplant 17: 649-656 (2011) (C) 2011 American Society fir Blood and Marrow Transplantation

语种英语
WOS记录号WOS:000290061500007
项目编号30725038 ; IRT0702 ; 2006AA02Z4A0
资助机构National Outstanding Yong Scientists&prime ; Foundation of China ; Program for Innovative Research Team in University ; HI-Tech Research Development Program of China 863
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62980
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Huang, Xiao-Jun,Xu, Lan-Ping,Liu, Kai-Yan,et al. Individualized Intervention Guided by BCR-ABL Transcript Levels after HLA-Identical Sibling Donor Transplantation Improves HSCT Outcomes for Patients with Chronic Myeloid Leukemia[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2011,17(5):649-656.
APA Huang, Xiao-Jun.,Xu, Lan-Ping.,Liu, Kai-Yan.,Liu, Dai-Hong.,Chen, Huan.,...&Wang, Yu.(2011).Individualized Intervention Guided by BCR-ABL Transcript Levels after HLA-Identical Sibling Donor Transplantation Improves HSCT Outcomes for Patients with Chronic Myeloid Leukemia.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,17(5),649-656.
MLA Huang, Xiao-Jun,et al."Individualized Intervention Guided by BCR-ABL Transcript Levels after HLA-Identical Sibling Donor Transplantation Improves HSCT Outcomes for Patients with Chronic Myeloid Leukemia".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 17.5(2011):649-656.
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