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学科主题: 公共卫生
题名:
Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers
作者: Guo, Song; Chen, Da Fang; Zhou, Dong Feng; Sun, Hong Qiang; Wu, Gui Ying; Haile, Colin N.; Kosten, Therese A.; Kosten, Thomas R.; Zhang, Xiang Yang
关键词: COMT ; polymorphism ; nicotine ; smoker ; dependence
刊名: PSYCHOPHARMACOLOGY
发表日期: 2007-03-01
DOI: 10.1007/s00213-006-0628-4
卷: 190, 期:4, 页:449-456
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]: METHYLTRANSFERASE COMT ; NICOTINE DEPENDENCE ; GENETIC-VARIATION ; TRANSPORTER GENE ; POPULATION ; BEHAVIOR ; WOMEN ; CONSUMPTION ; CESSATION ; JAPANESE
英文摘要:

Rationale Catechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual′s predisposition to developing nicotine dependence.

Subjects and Methods We studied the COMT Val108Met polymorphism in a male population of 203 current smokers, 66 former smokers, and 102 non-smokers. The age-adjusted odds ratios were estimated by multiple logistic regression models.

Results The results showed no significant association of the COMT Val108Met with initiation, persistent smoking, or smoking cessation. However, current smokers with the Met allele had significantly higher Fagerstrom Test for Nicotine Dependence scores (7.5 +/- 2.1 vs 6.8 +/- 1.8, p = 0.018) and started smoking significantly earlier (18.4 +/- 4.9 vs 20.1 +/- 5.9 years, p = 0.036).

Conclusions These results suggest that the COMT Val108Met polymorphism may not influence smoking status in a Chinese male population but may influence the age at which smoking started and smoking severity among smokers. However, the findings must be regarded as preliminary because of the relatively small sample size and marginal associations and should be replicated in a larger cohort.

语种: 英语
WOS记录号: WOS:000243926900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62981
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Int Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Huilongguan Hosp, Ctr Biol Psychait, Beijing, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Beijing 100083, Peoples R China
4.Beijing Anding Hosp Capital Univ Med Sci, Natl Drug Dependence Treatment Ctr, Beijing, Peoples R China
5.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA

Recommended Citation:
Guo, Song,Chen, Da Fang,Zhou, Dong Feng,et al. Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers[J]. PSYCHOPHARMACOLOGY,2007,190(4):449-456.
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