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Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers
Guo, Song; Chen, Da Fang; Zhou, Dong Feng; Sun, Hong Qiang; Wu, Gui Ying; Haile, Colin N.; Kosten, Therese A.; Kosten, Thomas R.; Zhang, Xiang Yang
关键词COMT polymorphism nicotine smoker dependence
刊名PSYCHOPHARMACOLOGY
2007-03-01
DOI10.1007/s00213-006-0628-4
190期:4页:449-456
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Pharmacology & Pharmacy ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Pharmacology & Pharmacy ; Psychiatry
关键词[WOS]METHYLTRANSFERASE COMT ; NICOTINE DEPENDENCE ; GENETIC-VARIATION ; TRANSPORTER GENE ; POPULATION ; BEHAVIOR ; WOMEN ; CONSUMPTION ; CESSATION ; JAPANESE
英文摘要

Rationale Catechol-O-methyltransferase (COMT) is an enzyme involved in the degradation and inactivation of the neurotransmitter dopamine, which is important in mediating drug reward such as nicotine in tobacco smoke. Different COMT alleles encode enzyme whose activity varies from three- to fourfold that may affect dopamine levels and alter subjective effects of nicotine. Recent evidence also suggests that a COMT polymorphism may be especially important in determining an individual′s predisposition to developing nicotine dependence.

Subjects and Methods We studied the COMT Val108Met polymorphism in a male population of 203 current smokers, 66 former smokers, and 102 non-smokers. The age-adjusted odds ratios were estimated by multiple logistic regression models.

Results The results showed no significant association of the COMT Val108Met with initiation, persistent smoking, or smoking cessation. However, current smokers with the Met allele had significantly higher Fagerstrom Test for Nicotine Dependence scores (7.5 +/- 2.1 vs 6.8 +/- 1.8, p = 0.018) and started smoking significantly earlier (18.4 +/- 4.9 vs 20.1 +/- 5.9 years, p = 0.036).

Conclusions These results suggest that the COMT Val108Met polymorphism may not influence smoking status in a Chinese male population but may influence the age at which smoking started and smoking severity among smokers. However, the findings must be regarded as preliminary because of the relatively small sample size and marginal associations and should be replicated in a larger cohort.

语种英语
WOS记录号WOS:000243926900005
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62981
专题北京大学公共卫生学院
作者单位1.Peking Univ, Int Mental Hlth, Beijing 100083, Peoples R China
2.Beijing Huilongguan Hosp, Ctr Biol Psychait, Beijing, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Stat, Beijing 100083, Peoples R China
4.Beijing Anding Hosp Capital Univ Med Sci, Natl Drug Dependence Treatment Ctr, Beijing, Peoples R China
5.Baylor Coll Med, VA Med Ctr, Menninger Dept Psychiat & Behav Sci, Houston, TX 77030 USA
推荐引用方式
GB/T 7714
Guo, Song,Chen, Da Fang,Zhou, Dong Feng,et al. Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers[J]. PSYCHOPHARMACOLOGY,2007,190(4):449-456.
APA Guo, Song.,Chen, Da Fang.,Zhou, Dong Feng.,Sun, Hong Qiang.,Wu, Gui Ying.,...&Zhang, Xiang Yang.(2007).Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers.PSYCHOPHARMACOLOGY,190(4),449-456.
MLA Guo, Song,et al."Association of functional catechol O-methyl transferase (COMT) Val108Met polymorphism with smoking severity and age of smoking initiation in Chinese male smokers".PSYCHOPHARMACOLOGY 190.4(2007):449-456.
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