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学科主题: 临床医学
题名:
HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han
作者: Liu, Xu1; Guo, Jianping1; Jia, Yuan1; Zhao, Yi2; Liu, Xia3; Cheng, Feng4; Li, Xiaoxia2; Zheng, Yi5; Shi, Xuhua5; Li, Haiyun5; Huang, Cibo6; Cheng, Yongjing6; Lai, Bei6; Huang, Yanhong7; Wang, Tian8; Ding, Bo9; Li, ZhangGuo1
刊名: PLOS ONE
发表日期: 2013-08-12
DOI: 10.1371/journal.pone.0071373
卷: 8, 期:8
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HLA ; SUSCEPTIBILITY ; PREDISPOSITION ; DISEASE ; GENE ; PROTECTION ; ALLELES ; PTPN22
英文摘要:

The association between Human Leukocyte Antigen (HLA) class II and rheumatoid arthritis (RA) has been extensively studied, but few reported DR-DQ haplotype. Here we investigated the association of HLA-DRB1, DQA1, DQB1, and DR-DQ haplotypes with RA susceptibility and with anti-CCP antibodies in 281 RA patients and 297 control in Han population. High-resolution genotyping were performed. The HLA-DRB1 shared epitope (SE)-encoding allele *0405 displayed the most significant RA association (P = 1.35x10(-6)). The grouped DRB1 SE alleles showed great association with RA (P = 3.88x10(-13)). The DRB1 DRRAA alleles displayed significant protective effects (P = 0.021). The SE-dependent DR-DQ haplotype SE-DQ3/4/5 remained strong association with both anti-CCP -positive (P = 3.71x10(-13)) and -negative RA (P = 3.89x10(-5)). Our study revealed that SE alleles and its haplotypes SE-DQ3/4/5 were highly associated with RA susceptibility in Han population. The SE-DQ3/4/5 haplotypes were associated with both anti-CCP positive RA and -negative RA.

语种: 英语
所属项目编号: 2010CB529105 ; 30901319 ; 2010DFB34000 ; 81120108020 ; 20110001110045 ; 7122196
项目资助者: National Basic Research Program of China (973 Program) ; General Program of the National Natural Science Foundation of China ; Program of International Science &amp ; Technology Cooperation from MOST ; Major International Joint Research Project from Natural Science Foundation of China ; Doctoral Fund of Ministry of Education of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000323097300111
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62984
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Xuanwu Hosp Capital Med Univ, Dept Rheumatol, Beijing, Peoples R China
2.Chao Yang Hosp, Dept Rheumatol, Beijing, Peoples R China
3.Beijing Hosp, Dept Rheumatol, Minist Hlth, Beijing, Peoples R China
4.Beijing Jishuitan Hosp, Dept Rheumatol, Beijing, Peoples R China
5.Peking Univ, Dept Rheumatol & Immunol, Peoples Hosp, Beijing 100871, Peoples R China
6.China Japan Friendship Hosp, Dept Rheumatol, Beijing, Peoples R China
7.Chinese Acad Agr Sci, Inst Vegetables & Flowers, Beijing 100193, Peoples R China
8.Capital Med Univ, Beijing Anzhen Hosp, Dept Internal Med, Beijing, Peoples R China
9.Karolinska Inst, Inst Environm Med, S-10401 Stockholm, Sweden

Recommended Citation:
Liu, Xu,Guo, Jianping,Jia, Yuan,et al. HLA-DRB1 Shared Epitope-Dependent DR-DQ Haplotypes Are Associated with Both Anti-CCP-Positive and -Negative Rheumatoid Arthritis in Chinese Han[J]. PLOS ONE,2013,8(8).
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