北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
The Impact of CD34(+) Cell Dose on Platelet Engraftment in Pediatric Patients Following Unmanipulated Haploidentical Blood and Marrow Transplantation
作者: Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Han, Wei; Chen, Yu-Hong; Wang, Yu; Chen, Huan; Wang, Jing-Zhi; Zhang, Xiao-Hui; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词: CD34(+) cells ; engraftment ; pediatric ; unmanipulated blood and marrow transplantation
刊名: PEDIATRIC BLOOD & CANCER
发表日期: 2009-12-01
DOI: 10.1002/pbc.22159
卷: 53, 期:6, 页:1100-1106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Hematology ; Pediatrics
研究领域[WOS]: Oncology ; Hematology ; Pediatrics
关键词[WOS]: MISMATCHED PARENTAL DONORS ; HLA-IDENTICAL SIBLINGS ; PERIPHERAL-BLOOD ; ALLOGENEIC TRANSPLANTATION ; HEMATOLOGICAL MALIGNANCIES ; CLINICAL-OUTCOMES ; ACUTE-LEUKEMIA ; GRAFT FAILURE ; HOST-DISEASE ; CHILDREN
英文摘要:

Objective. Unmanipulated haploidentical blood and marrow transplantation has been developed as an alternative transplant strategy for pediatric patients with hematological diseases. The aim of this study was to investigate the effects of donor and recipient characteristics on hematopoietic recovery in pediatric patients following unmanipulated haploidentical transplantation. Methods. Factors correlating with hematopoietic recovery in 133 pediatric patients after unmanipulated haploidentical transplantation were analyzed retrospectively. Results. All patients reached an absolute neutrophil Count of 500/mu l in a median of 12 days (range, 9-49 days). One hundred thirty-three patients reached all untransfused platelet count of more than 20,000/mu l in a median of 15 days (range, 7-180 days). Univariate analysis showed five factors associated with platelet engraftment. These were time to transplantation after diagnosis (P=0.072), infused nuclear cells/kg of recipient weight (P=0.028), CD3(+) cells/kg of recipient weight (P=0.082), CD4(+) cells/kg of recipient weight (P=0.083), and CD34(+) cells/kg of recipient weight (P=0.012). Multivariate analysis showed that infused CD34+ cells/kg of recipient weight (CD34(+) cells more than 2.42 x 10(6)/kg vs. less than or equal to 2.42 x 10(6)/kg, HR = 1.733; 95% Cl 1.222-2.549; P=0.002) were significantly associated with an increased risk of platelet engraftment. Patients receiving a CD34(+) cell dose more than 2.42 x 10(6)/kg had a short time [12 days (range, 7-176 days)] to achieve an untransfused platelet engraftment, compared to 18 days (range, 7-180 days) in patients receiving a lower dose (P<0.001). Conclusions. Our results suggest that low number of CD34(+) cells in allografts is a critical factor associated with delayed platelet engraftment after unimanipulated haploidentical transplantation in pediatric patients. Pediatr Blood Cancer 2009;53:1100-1106. (C) 2009 Wiley-Liss, Inc.

语种: 英语
所属项目编号: 30725038 ; 2005-1010 ; IRT0702
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Scientific Research Fund for Capital Medicine Development ; Program for Innovative Research Team in University
WOS记录号: WOS:000270440900033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62988
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Chang, Ying-Jun,Xu, Lan-Ping,Liu, Dai-Hong,et al. The Impact of CD34(+) Cell Dose on Platelet Engraftment in Pediatric Patients Following Unmanipulated Haploidentical Blood and Marrow Transplantation[J]. PEDIATRIC BLOOD &amp; CANCER,2009,53(6):1100-1106.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Chang, Ying-Jun]'s Articles
[Xu, Lan-Ping]'s Articles
[Liu, Dai-Hong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Chang, Ying-Jun]‘s Articles
[Xu, Lan-Ping]‘s Articles
[Liu, Dai-Hong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace