IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
The Impact of CD34(+) Cell Dose on Platelet Engraftment in Pediatric Patients Following Unmanipulated Haploidentical Blood and Marrow Transplantation
Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Liu, Kai-Yan; Han, Wei; Chen, Yu-Hong; Wang, Yu; Chen, Huan; Wang, Jing-Zhi; Zhang, Xiao-Hui; Zhao, Xiang-Yu; Huang, Xiao-Jun
关键词CD34(+) cells engraftment pediatric unmanipulated blood and marrow transplantation
刊名PEDIATRIC BLOOD & CANCER
2009-12-01
DOI10.1002/pbc.22159
53期:6页:1100-1106
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Hematology ; Pediatrics
研究领域[WOS]Oncology ; Hematology ; Pediatrics
关键词[WOS]MISMATCHED PARENTAL DONORS ; HLA-IDENTICAL SIBLINGS ; PERIPHERAL-BLOOD ; ALLOGENEIC TRANSPLANTATION ; HEMATOLOGICAL MALIGNANCIES ; CLINICAL-OUTCOMES ; ACUTE-LEUKEMIA ; GRAFT FAILURE ; HOST-DISEASE ; CHILDREN
英文摘要

Objective. Unmanipulated haploidentical blood and marrow transplantation has been developed as an alternative transplant strategy for pediatric patients with hematological diseases. The aim of this study was to investigate the effects of donor and recipient characteristics on hematopoietic recovery in pediatric patients following unmanipulated haploidentical transplantation. Methods. Factors correlating with hematopoietic recovery in 133 pediatric patients after unmanipulated haploidentical transplantation were analyzed retrospectively. Results. All patients reached an absolute neutrophil Count of 500/mu l in a median of 12 days (range, 9-49 days). One hundred thirty-three patients reached all untransfused platelet count of more than 20,000/mu l in a median of 15 days (range, 7-180 days). Univariate analysis showed five factors associated with platelet engraftment. These were time to transplantation after diagnosis (P=0.072), infused nuclear cells/kg of recipient weight (P=0.028), CD3(+) cells/kg of recipient weight (P=0.082), CD4(+) cells/kg of recipient weight (P=0.083), and CD34(+) cells/kg of recipient weight (P=0.012). Multivariate analysis showed that infused CD34+ cells/kg of recipient weight (CD34(+) cells more than 2.42 x 10(6)/kg vs. less than or equal to 2.42 x 10(6)/kg, HR = 1.733; 95% Cl 1.222-2.549; P=0.002) were significantly associated with an increased risk of platelet engraftment. Patients receiving a CD34(+) cell dose more than 2.42 x 10(6)/kg had a short time [12 days (range, 7-176 days)] to achieve an untransfused platelet engraftment, compared to 18 days (range, 7-180 days) in patients receiving a lower dose (P<0.001). Conclusions. Our results suggest that low number of CD34(+) cells in allografts is a critical factor associated with delayed platelet engraftment after unimanipulated haploidentical transplantation in pediatric patients. Pediatr Blood Cancer 2009;53:1100-1106. (C) 2009 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000270440900033
项目编号30725038 ; 2005-1010 ; IRT0702
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Scientific Research Fund for Capital Medicine Development ; Program for Innovative Research Team in University
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62988
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Ying-Jun,Xu, Lan-Ping,Liu, Dai-Hong,et al. The Impact of CD34(+) Cell Dose on Platelet Engraftment in Pediatric Patients Following Unmanipulated Haploidentical Blood and Marrow Transplantation[J]. PEDIATRIC BLOOD &amp; CANCER,2009,53(6):1100-1106.
APA Chang, Ying-Jun.,Xu, Lan-Ping.,Liu, Dai-Hong.,Liu, Kai-Yan.,Han, Wei.,...&Huang, Xiao-Jun.(2009).The Impact of CD34(+) Cell Dose on Platelet Engraftment in Pediatric Patients Following Unmanipulated Haploidentical Blood and Marrow Transplantation.PEDIATRIC BLOOD & CANCER,53(6),1100-1106.
MLA Chang, Ying-Jun,et al."The Impact of CD34(+) Cell Dose on Platelet Engraftment in Pediatric Patients Following Unmanipulated Haploidentical Blood and Marrow Transplantation".PEDIATRIC BLOOD & CANCER 53.6(2009):1100-1106.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chang, Ying-Jun]的文章
[Xu, Lan-Ping]的文章
[Liu, Dai-Hong]的文章
百度学术
百度学术中相似的文章
[Chang, Ying-Jun]的文章
[Xu, Lan-Ping]的文章
[Liu, Dai-Hong]的文章
必应学术
必应学术中相似的文章
[Chang, Ying-Jun]的文章
[Xu, Lan-Ping]的文章
[Liu, Dai-Hong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。