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学科主题: 临床医学
题名:
Biological markers as predictive factors of response to neoadjuvant taxanes and anthracycline chemotherapy in breast carcinoma
作者: Zhou Bo; Yang De-Qi; Xie Fei
关键词: breast neoplasms ; neoadjuvant chemotherapy ; predictive factor
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2008-03-05
卷: 121, 期:5, 页:387-391
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: COMPLETE PATHOLOGICAL RESPONSE ; SURGICAL ADJUVANT BREAST ; PROJECT PROTOCOL B-27 ; CANCER PATIENTS ; PREOPERATIVE DOXORUBICIN ; DOCETAXEL ; P53 ; EXPRESSION ; CYCLOPHOSPHAMIDE ; OVEREXPRESSION
英文摘要:

Background Neoadjuvant chemotherapy provides an excellent model for evaluation of potential predictive factors. The objective of this study was to evaluate the predictive value of different biological factors in breast cancer patients treated with neoadjuvant taxane and anthracycline chemotherapy.

Methods One hundred and thirty-five patients treated with 4 cycles of neoadjuvant taxanes and anthracycline were included in this retrospective study. Using pretreatment biopsy materials, immunohistochemical studies were performed for estrogen receptor (ER), progesterone receptor (PgR), HER-2, Ki-67 and p53 protein expression. The associations among biological markers and clinical and pathological complete response (pCR) were analyzed.

Results The overall clinical response was 86%, including 33% clinical complete response (cCR) and 53% clinical partial response. The pCR was just 17%. In the univariate analysis, only HER-2 overexpression was predictive of cCR to neoadjuvant chemotherapy (P=0.018). No significant associations between other biological factors and cCR were found. Absence of ER, PgR expression and overexpression of HER-2 were predictive of the pCR (P=0.002, 0.001, 0.01, respectively). Ki-67 and p53 failed to show an association with pCR. In multivariate analysis, overexpression of HER-2 remained as an independent variable in predicting the cCR (P=0.021). However, negative ER was the only parameter that maintained statistical significance in predicting the pCR (P=0.001).

Conclusions Patients with overexpression of HER-2 and negative hormonal receptor status are much more likely to respond to neoadjuvant taxane and anthracycline chemotherapy than those with the opposite characteristics. These factors could serve as predictive markers for this regimen.

语种: 英语
WOS记录号: WOS:000254358500001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62994
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Breast Surg, Beijing 100044, Peoples R China

Recommended Citation:
Zhou Bo,Yang De-Qi,Xie Fei. Biological markers as predictive factors of response to neoadjuvant taxanes and anthracycline chemotherapy in breast carcinoma[J]. CHINESE MEDICAL JOURNAL,2008,121(5):387-391.
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