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学科主题: 临床医学
题名:
ABCA1 rs1883025 Polymorphism Shows No Association with Neovascular Age-Related Macular Degeneration or Polypoidal Choroidal Vasculopathy in a Northern Chinese Population
作者: Li, Fangting1,2,3; Li, Yingjie4; Li, Mingwu1,2,3; Sun, Yaoyao1,2,3; Bai, Yujing1,2,3; Yang, Fei1,2,3; Guo, Jing1,2,3; Chen, Yi1,2,3; Huang, Lvzhen1,2,3; Li, Xiaoxin1,2,3
关键词: Age-related macular degeneration, neovascular ; Polypoidal choroidal vasculopathy ; ABCA1 ; High-density lipoprotein cholesterol ; Northern Chinese population
刊名: OPHTHALMIC RESEARCH
发表日期: 2014
DOI: 10.1159/000357978
卷: 51, 期:4, 页:210-215
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: ATP-BINDING CASSETTE ; GENETIC-VARIANTS ; COMMON VARIANTS ; LOCI ; SUSCEPTIBILITY ; THERAPY ; CLONING ; TIMP3 ; RISK
英文摘要:

Purpose: To analyze the association between ABCA1 rs1883025 variants with neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a northern Chinese population. Methods: The study enrolled 900 subjects, including 300 controls, 300 cases with nAMD and 300 cases with PCV. Genomic DNA was extracted from venous blood leukocytes. Single-nucleotide polymorphisms in the ABCA1 (rs1883025) gene were genotyped by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. Results: The ABCA1 rs1883025 polymorphism was not significantly associated with nAMD (22.5%; p>0.05) or PCV (20.8%; p>0.05) in a northern Chinese population. The association remained insignificant after adjustment for age and gender differences (p>0.05). Conclusions: This study suggests that ABCA1 rs1883025 variants are not associated with nAMD or PCV in a Chinese population, which is likely due to an ethnic difference. (C) 2014 S. Karger AG, Basel

语种: 英语
所属项目编号: 2011CB510200 ; 81100666 ; Z121100005312006
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Research Fund for Science and Technology Program of Beijing
WOS记录号: WOS:000335938900006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62996
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Chinese Acad Med Sci, Peking Union Med Coll, Key Lab Vis Loss & Restorat, Minist Educ, Beijing 100730, Peoples R China
3.Chinese Acad Med Sci, Peking Union Med Coll, Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing 100730, Peoples R China
4.Chinese Acad Med Sci, Peking Union Med Coll, Dept Abdominal Surg Oncol, Canc Inst & Hosp, Beijing 100730, Peoples R China

Recommended Citation:
Li, Fangting,Li, Yingjie,Li, Mingwu,et al. ABCA1 rs1883025 Polymorphism Shows No Association with Neovascular Age-Related Macular Degeneration or Polypoidal Choroidal Vasculopathy in a Northern Chinese Population[J]. OPHTHALMIC RESEARCH,2014,51(4):210-215.
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