学科主题基础医学
Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression
Feng, Ruopeng1,2; Zhou, Shixin1,2; Liu, Yinan1,2; Song, Daijun1,2; Luan, Zhilin1,2; Dai, Xin1,2,3; Li, Yang1,2; Tang, Na1,2; Wen, Jinhua1,2; Li, Lingsong1,2,3
关键词apoptosis neural stem cell SRY (sex-determining region Y)-box 2 (Sox2) survivin
刊名BIOCHEMICAL JOURNAL
2013-03-15
DOI10.1042/BJ20120924
450期:0页:459-468
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]IMPAIRED NEUROGENESIS ; INHIBITS APOPTOSIS ; CYTOCHROME-C ; SELF-RENEWAL ; DEATH ; MITOCHONDRIA ; SMAC/DIABLO ; COMPLEX ; STRESS ; BRAIN
英文摘要

The transcription factor Sox2 [SRY (sex-determining region Y)-box 2] is essential for the regulation of self-renewal and homoeostasis of NSCs (neural stem cells) during brain development. However, the downstream targets of Sox2 and its underlying molecular mechanism are largely unknown. In the present study, we found that Sox2 directly up-regulates the expression of survivin, which inhibits the mitochondria-dependent apoptotic pathway in NSCs. Although overexpression of Sox2 elevates survivin expression, knockdown of Sox2 results in a decrease in survivin expression, thereby initiating the mitochondria-dependent apoptosis related to caspase 9 activation. Furthermore, cell apoptosis owing to knockdown of Sox2 can be rescued by ectopically expressing survivin in NSCs as well as in the mouse brain, as demonstrated by an in uteroinjection approach. In short, we have found a novel Sox2/survivin pathway that regulates NSC survival and homoeostasis, thus revealing a new mechanism of brain development, neurological degeneration and such aging-related disorders.

语种英语
WOS记录号WOS:000315745300003
项目编号2011CB966203 ; 2011CBA01102 ; 2011DFA31040 ; 2011AA020106 ; 31171417 ; 31000653 ; 2011ZX09102-010-02 ; 5112019
资助机构973 Program ; International S& ; T Cooperation Program ; 863 Program from the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; New Drug Innovation of China ; Beijing Natural Science Foundation
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/62997
专题北京大学基础医学院_北京大学干细胞研究中心
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Stem Cell Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Shanghai Adv Res Inst, SARI Ctr Stem Cell & Nanomed, Shanghai 201203, Peoples R China
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Feng, Ruopeng,Zhou, Shixin,Liu, Yinan,et al. Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression[J]. BIOCHEMICAL JOURNAL,2013,450(0):459-468.
APA Feng, Ruopeng.,Zhou, Shixin.,Liu, Yinan.,Song, Daijun.,Luan, Zhilin.,...&Li, Lingsong.(2013).Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression.BIOCHEMICAL JOURNAL,450(0),459-468.
MLA Feng, Ruopeng,et al."Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression".BIOCHEMICAL JOURNAL 450.0(2013):459-468.
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