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学科主题: 基础医学
题名:
Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression
作者: Feng, Ruopeng1,2; Zhou, Shixin1,2; Liu, Yinan1,2; Song, Daijun1,2; Luan, Zhilin1,2; Dai, Xin1,2,3; Li, Yang1,2; Tang, Na1,2; Wen, Jinhua1,2; Li, Lingsong1,2,3
关键词: apoptosis ; neural stem cell ; SRY (sex-determining region Y)-box 2 (Sox2) ; survivin
刊名: BIOCHEMICAL JOURNAL
发表日期: 2013-03-15
DOI: 10.1042/BJ20120924
卷: 450, 期:0, 页:459-468
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: IMPAIRED NEUROGENESIS ; INHIBITS APOPTOSIS ; CYTOCHROME-C ; SELF-RENEWAL ; DEATH ; MITOCHONDRIA ; SMAC/DIABLO ; COMPLEX ; STRESS ; BRAIN
英文摘要:

The transcription factor Sox2 [SRY (sex-determining region Y)-box 2] is essential for the regulation of self-renewal and homoeostasis of NSCs (neural stem cells) during brain development. However, the downstream targets of Sox2 and its underlying molecular mechanism are largely unknown. In the present study, we found that Sox2 directly up-regulates the expression of survivin, which inhibits the mitochondria-dependent apoptotic pathway in NSCs. Although overexpression of Sox2 elevates survivin expression, knockdown of Sox2 results in a decrease in survivin expression, thereby initiating the mitochondria-dependent apoptosis related to caspase 9 activation. Furthermore, cell apoptosis owing to knockdown of Sox2 can be rescued by ectopically expressing survivin in NSCs as well as in the mouse brain, as demonstrated by an in uteroinjection approach. In short, we have found a novel Sox2/survivin pathway that regulates NSC survival and homoeostasis, thus revealing a new mechanism of brain development, neurological degeneration and such aging-related disorders.

语种: 英语
所属项目编号: 2011CB966203 ; 2011CBA01102 ; 2011DFA31040 ; 2011AA020106 ; 31171417 ; 31000653 ; 2011ZX09102-010-02 ; 5112019
项目资助者: 973 Program ; International S& ; T Cooperation Program ; 863 Program from the Ministry of Science and Technology of China ; National Natural Science Foundation of China ; New Drug Innovation of China ; Beijing Natural Science Foundation
WOS记录号: WOS:000315745300003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62997
Appears in Collections:基础医学院_北京大学干细胞研究中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Stem Cell Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Shanghai Adv Res Inst, SARI Ctr Stem Cell & Nanomed, Shanghai 201203, Peoples R China

Recommended Citation:
Feng, Ruopeng,Zhou, Shixin,Liu, Yinan,et al. Sox2 protects neural stem cells from apoptosis via up-regulating survivin expression[J]. BIOCHEMICAL JOURNAL,2013,450(0):459-468.
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