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学科主题: 临床医学
题名:
Sphingosylphosphorylcholine induces alpha-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P(2) receptor and Rho/Rho-kinase pathway
作者: Wang, X. Q.1,2; Mao, L. J.3; Fang, Q. H.4; Kobayashi, T.5; Kim, H. J.6; Sugiura, H.7; Kawasaki, S.8; Togo, S.9,10; Kamio, K.11; Liu, X.1; Rennard, S. I.1
关键词: SPC ; Tissue repair ; Fibroblast
刊名: PROSTAGLANDINS & OTHER LIPID MEDIATORS
发表日期: 2014
DOI: 10.1016/j.prostaglandins.2014.02.002
卷: 108, 页:23-30
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Cell Biology
研究领域[WOS]: Biochemistry & Molecular Biology ; Cell Biology
关键词[WOS]: SPHINGOSINE 1-PHOSPHATE ; COLLAGEN MATRICES ; RHO GTPASES ; SPHINGOSINE-1-PHOSPHATE ; MYOFIBROBLAST ; CYTOSKELETON ; INTEGRINS ; MIGRATION ; PROTEINS ; GROWTH
英文摘要:

Chronic airway diseases like COPD and asthma are usually accompanied with airway fibrosis. Myofibroblasts, which are characterized by expression of smooth muscle actin (alpha-SMA), play an important role in a variety of developmental and pathological processes, including fibrosis and wound healing. Sphingosylphosphorylcholine (SPC), a sphingolipid metabolite, has been implicated in many physiological and pathological conditions. The current study tested the hypothesis that SPC may modulate tissue remodeling by affecting the expression of a-SMA in human fetal lung fibroblast (HFL-1) and fibroblast mediated gel contraction. The results show that SPC stimulates a-SMA expression in HFL-1 and augments HFL-1 mediated collagen gel contraction in a time- and concentration-dependent manner. The a-SMA protein expression and fibroblast gel contraction induced by SPC was not blocked by TGF-beta 1 neutralizing antibody: However, it was significantly blocked by S1P2 receptor antagonist JTE-013, the Rho-specific inhibitor C3 exoenzyme, and a Rho-kinase inhibitor Y-27632. These findings suggest that SPC stimulates a-SMA protein expression and HFL-1 mediated collagen gel contraction via S1P2 receptor and Rho/Rho kinase pathway, and by which mechanism, SPC may be involved in lung tissue remodeling. (c) 2014 Published by Elsevier Inc.

语种: 英语
项目资助者: Larson Endowment, University of Nebraska Medical Center ; AstraZeneca ; Biomarck ; Centocor ; Mpex ; Nabi ; Novartis ; Otsuka
WOS记录号: WOS:000336474600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/62999
Appears in Collections:北京大学第三临床医学院_职业病科_期刊论文

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作者单位: 1.Univ Nebraska Med Ctr, Dept Internal Med, Omaha, NE 68198 USA
2.Hebei United Univ, Affiliated Hosp, Dept Resp Dis, Tangshan, Hebei Province, Peoples R China
3.Peking Univ, Hosp 3, Res Ctr Occupat Med, Beijing 100191, Peoples R China
4.Capital Med Univ, Beijing Shijitan Hosp, Dept Pulm & Crit Care, Beijing 100038, Peoples R China
5.Mie Univ, Sch Med, Dept Pulm & Crit Care Med, Tsu, Mie 514, Japan
6.WonKuang Univ, Sch Med, SanBon Hosp, Dept Internal Med, Seoul, South Korea
7.Univ Tokyo, Grad Sch Med, Dept Resp Med, Tokyo, Japan
8.Juntendo Univ, Fac Med, Div Resp Med, Tokyo, Japan
9.Grad Sch Med, Tokyo, Japan
10.Tohoku Univ, Grad Sch Med, Dept Resp Med, Aoba Ku, Sendai, Miyagi 9808574, Japan
11.Nippon Med Sch, Dept Pulm Med Infect & Oncol, Tokyo 113, Japan

Recommended Citation:
Wang, X. Q.,Mao, L. J.,Fang, Q. H.,et al. Sphingosylphosphorylcholine induces alpha-smooth muscle actin expression in human lung fibroblasts and fibroblast-mediated gel contraction via S1P(2) receptor and Rho/Rho-kinase pathway[J]. PROSTAGLANDINS & OTHER LIPID MEDIATORS,2014,108:23-30.
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