北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学医药卫生分析中心  > 期刊论文
学科主题: 公共卫生
题名:
Tc-99m-3PRGD(2) SPECT/CT predicts the outcome of advanced nonsquamous non-small cell lung cancer receiving chemoradiotherapy plus bevacizumab
作者: Ma, Qingjie1; Min, Kaiyin1; Wang, Ting1; Chen, Bin1; Wen, Qiang1; Wang, Fan2; Ji, Tiefeng1; Gao, Shi1
关键词: Tc-99m-3PRGD(2) ; SPECT/CT ; Lung cancer ; Response ; Prediction ; Bevacizumab
刊名: ANNALS OF NUCLEAR MEDICINE
发表日期: 2015-07-01
DOI: 10.1007/s12149-015-0975-5
卷: 29, 期:6, 页:519-527
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: POSITRON-EMISSION-TOMOGRAPHY ; DRUG-RESISTANCE ; BREAST-CANCER ; SOLID TUMOR ; INTEGRIN ; ADENOCARCINOMA ; EXPRESSION ; CISPLATIN ; SURVIVAL ; THERAPY
英文摘要:

Functional imaging can help clinicians assess the individual response of advanced nonsquamous non-small cell lung cancer (NSCLC) to chemoradiation therapy plus bevacizumab. Our purpose is to investigate the ability of Tc-99m-3PRGD(2) single photon emission computed tomography/computed tomography (SPECT/CT) in predicting the early response to treatment.

Patients with advanced nonsquamous NSCLC diagnosed by histological or cytological examination were imaged with Tc-99m-3PRGD(2) SPECT/CT at 3 time points: 1-3 days before the start of treatment (SPECT1), 40 Gy radiotherapy with 2 cycles of chemotherapy plus bevacizumab (SPECT2) and 4 weeks after chemoradiotherapy plus bevacizumab (SPECT3). The images were evaluated semiquantitatively by measuring the tumor to non-tumor ratio (T/N) and calculating the percentage change in T/N ratio. Short-term outcome was assessed by the treatment response evaluation according to the Response Evaluation Criteria in Solid Tumors criteria as: complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD). Patients were divided two groups: responders (CR and PR) and nonresponders (SD and PD). To determine a threshold for percent reduction in T/N ratios, receiver-operating characteristic (ROC) curve analysis was used. Patients were grouped again based on the threshold of P1 (the change percentage from SPECT1 to SPECT2) and P2 (the change percentage from SPECT1 to SPECT3): P1 responders and P1 nonresponders; P2 responders and P2 nonresponders. Patients were followed up starting 4 weeks after completion of therapy and then every 3 months for the first 2 years and every 6 months after 2 years. OS of P1 responders, P1 nonresponders, P2 responders and P2 nonresponders was estimated and graphically illustrated using the Kaplan-Meier method and the log-rank test was used to test the null hypotheses of equal OS in subgroups of patients.

A total of 28 patients completed all imaging and treatment. All primary lung tumors were well visualized on SPECT1. The mean T/N ratio of SPECT1 in responders and nonresponders was not statistically different (2.73 +/- A 0.59 vs. 2.59 +/- A 0.52, p > 0.05). At SPECT2 and SPECT3, the mean T/N ratios were both lower in the responders compared with the nonresponders and had statistical significance (p < 0.05). P1 and P2 in the responders was larger than the nonresponders with significant difference (P1: 34.18 +/- A 21.55 % vs. 9.02 +/- A 14.02 %, p < 0.05; P2: 53.02 +/- A 15.50 % vs. 7.74 +/- A 37.95 %, p < 0.05). The optimal threshold of P1 that can discriminate between P1 responders and P1 nonresponders was greater than 25.9 % reduction, and that of P2 that can discriminate between P2 responders and P2 nonresponders was 34.0 % reduction. The area under the ROC curve (AUC) of P1 and P2 for determining residual disease was 0.856 and 0.909, respectively; but there was no statistical significance between them (p > 0.05). There was a significant difference for OS between P1 responders and P1 nonresponders (p < 0.05), and also for OS between P2 responders and P2 nonresponders (p < 0.05). But there was no difference between the P1 responders and P2 responders (p > 0.05), or between the P1 nonresponders and P2 nonresponders (p > 0.05).

A Tc-99m-3PRGD(2) SPECT/CT after two cycles of chemoradiotherapy plus bevacizumab can predict patients who will have a better response to treatment and survival.

语种: 英语
所属项目编号: 81271606 ; 20150520154JH
项目资助者: National Natural Science Foundation of China (NSFC) ; Research Fund of Science and Technology Department of Jilin Province
WOS记录号: WOS:000358175300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63000
Appears in Collections:北京大学医药卫生分析中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Jilin Univ, Dept Nucl Med, China Japan Union Hosp, Changchun 130023, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100871, Peoples R China

Recommended Citation:
Ma, Qingjie,Min, Kaiyin,Wang, Ting,et al. Tc-99m-3PRGD(2) SPECT/CT predicts the outcome of advanced nonsquamous non-small cell lung cancer receiving chemoradiotherapy plus bevacizumab[J]. ANNALS OF NUCLEAR MEDICINE,2015,29(6):519-527.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Ma, Qingjie]'s Articles
[Min, Kaiyin]'s Articles
[Wang, Ting]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Ma, Qingjie]‘s Articles
[Min, Kaiyin]‘s Articles
[Wang, Ting]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace