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学科主题: 口腔医学
题名:
Proteomic Analysis of RBP4/Vitamin A in Children with Cleft Lip and/or Palate
作者: Zhang, J.1; Zhou, S.1; Zhang, Q.2; Feng, S.3; Chen, Y.3; Zheng, H.1; Wang, X.1; Zhao, W.4; Zhang, T.5; Zhou, Y.1; Deng, H.3; Lin, J.1; Chen, F.2
关键词: retinol-binding proteins ; vitamins ; proteomics ; craniofacial abnormalities ; congenital ; non-syndromic
刊名: JOURNAL OF DENTAL RESEARCH
发表日期: 2014-06-01
DOI: 10.1177/0022034514530397
卷: 93, 期:6, 页:547-552
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: RETINOL-BINDING-PROTEIN ; INSULIN-RESISTANCE ; SERUM RETINOL ; ACID ; ASSOCIATION ; CELLS
英文摘要:

Cleft of the lip and/or palate (CLP) is one of the most common congenital craniofacial defects. Non-syndromic CLP (NSCLP) is a multifactorial disease influenced by the interaction of genetic and environmental factors. However, there are few studies reporting on the developmental or metabolic status of babies with NSCLP after birth. In our study, we sought to identify and evaluate the differential expression of serum protein profiles in NSCLP children and unaffected babies. Thus, a ′shotgun proteomics′ approach was first used to analyze the plasma proteome of 13 children with NSCLP and 10 control children, aged 2 to 3.5 years. In total, more than 300 proteins were identified in the serum sample. With gene ontology (GO) analysis, we detected many differentially expressed proteins that could be related to NSCLP, including those involved in lipoprotein metabolism, insulin-like growth-factor-related processes, and so on, especially the proteins involved in retinol transport. Retinol binding protein 4 (RBP4), one protein of the retinol transport category, was significantly decreased in the NSCLP group. Thus, serum vitamin A levels were further determined by high-performance liquid chromatography (HPLC). A significant difference (p < .01) was also found in vitamin A concentrations, consistent with the trend of RBP4. Our results indicated that reduced levels of RBP4 and vitamin A were related to newborns with NSCLP and should thus receive more attention. These results also suggest that vitamin A supplementation might be necessary at an early stage.

语种: 英语
所属项目编号: 81200762 ; PKUSS20110301
项目资助者: National Natural Science Foundation of China ; Peking University School of Stomatology
WOS记录号: WOS:000336496100003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63001
Appears in Collections:北京大学口腔医学院_牙周科_期刊论文

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作者单位: 1.Yantai Stomatol Hosp, Yantai, Shandong, Peoples R China
2.Tsinghua Univ, Sch Life Sci, Beijing 100084, Peoples R China
3.Peking Univ, Dept Orthodont, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
4.Peking Univ, Ctr Lab, Sch & Hosp Stomatol, Beijing 100871, Peoples R China
5.Southern Med Univ, Dept Orthodont, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China

Recommended Citation:
Zhang, J.,Zhou, S.,Zhang, Q.,et al. Proteomic Analysis of RBP4/Vitamin A in Children with Cleft Lip and/or Palate[J]. JOURNAL OF DENTAL RESEARCH,2014,93(6):547-552.
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