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Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?
Yang Rui; Wang Ying; Qiao Jie; Liu Ping; Geng Li; Guo Yan-li
关键词human papillomaviruses thin-layer preparation cytologic test hybrid capture II in-vitro fertilization and embryo transfer
刊名CHINESE MEDICAL JOURNAL
2013-02-20
DOI10.3760/cma.j.issn.0366-6999.20121625
126期:4页:683-687
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]CERVICAL HUMAN-PAPILLOMAVIRUS ; PREVALENCE ; WOMEN ; DNA ; ASSOCIATION ; HPV ; APOPTOSIS ; CYTOLOGY ; QUALITY ; SEMEN
英文摘要

Background Some studies suggested that human papillomavirus (HPV) infection could reduce the clinical pregnancy rate and double the spontaneous abortion rate compared with non-infected women after in-vitro fertilization and embryo transfer (IVF-ET). But some other studies showed there was no difference between HPV infected and non-infected groups of ART outcomes. The role of HPV infection in infertile women undergoing IVF treatments has been a controversial issue which this article attempts to investigate.

Methods This is a retrospective analysis of 3880 infertile women undergoing IVF treatment at Peking University Third hospital reproductive medical center in 2008. Patients with abnormal thin-layer preparation cytologic test (TCT) results who underwent fresh cycle embryo transfer were divided into an HPV positive group (n=56) and an HPV negative group (n=56). The clinical parameters were compared (using Student′s t-test and chi-squared test). Univariate and multivariate analyses were taken to see if HPV infection affects the clinical pregnancy rate.

Results Of the 3880 cases 157 had TCT abnormality (4.0%). Of the 149 patients who had HPV test results, 112 women (81.2%) received a fresh cycle embryo transfer. Each group had 56 cases. The patients were of similar age and BMI, basic hormone levels, and infertile factors were similar. The gonadotropin use, oocyte retrieval number, clinical pregnancy rate, abortion rate and newborn condition were all similar between groups. Analyses showed neither HPV infection nor HPV hybrid capture (HC) II results affected clinical pregnancy rate after IVF treatments, but the FSH level did.

Conclusion HPV positivity did not appear to impact assisted reproductive technology (ART) success. "Extensive treatment" for HPV before IVF was not recommended because treatment time will increase age and reduce ovarian function, which will lead to inferior IVF outcomes.

语种英语
WOS记录号WOS:000319793800015
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63010
专题北京大学临床肿瘤学院_药剂科
北京大学第三临床医学院_妇产科
北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China
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GB/T 7714
Yang Rui,Wang Ying,Qiao Jie,et al. Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?[J]. CHINESE MEDICAL JOURNAL,2013,126(4):683-687.
APA Yang Rui,Wang Ying,Qiao Jie,Liu Ping,Geng Li,&Guo Yan-li.(2013).Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?.CHINESE MEDICAL JOURNAL,126(4),683-687.
MLA Yang Rui,et al."Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?".CHINESE MEDICAL JOURNAL 126.4(2013):683-687.
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