北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 生殖医学中心  > 期刊论文
学科主题: 临床医学
题名:
Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?
作者: Yang Rui; Wang Ying; Qiao Jie; Liu Ping; Geng Li; Guo Yan-li
关键词: human papillomaviruses ; thin-layer preparation cytologic test ; hybrid capture II ; in-vitro fertilization and embryo transfer
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2013-02-20
DOI: 10.3760/cma.j.issn.0366-6999.20121625
卷: 126, 期:4, 页:683-687
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: CERVICAL HUMAN-PAPILLOMAVIRUS ; PREVALENCE ; WOMEN ; DNA ; ASSOCIATION ; HPV ; APOPTOSIS ; CYTOLOGY ; QUALITY ; SEMEN
英文摘要:

Background Some studies suggested that human papillomavirus (HPV) infection could reduce the clinical pregnancy rate and double the spontaneous abortion rate compared with non-infected women after in-vitro fertilization and embryo transfer (IVF-ET). But some other studies showed there was no difference between HPV infected and non-infected groups of ART outcomes. The role of HPV infection in infertile women undergoing IVF treatments has been a controversial issue which this article attempts to investigate.

Methods This is a retrospective analysis of 3880 infertile women undergoing IVF treatment at Peking University Third hospital reproductive medical center in 2008. Patients with abnormal thin-layer preparation cytologic test (TCT) results who underwent fresh cycle embryo transfer were divided into an HPV positive group (n=56) and an HPV negative group (n=56). The clinical parameters were compared (using Student′s t-test and chi-squared test). Univariate and multivariate analyses were taken to see if HPV infection affects the clinical pregnancy rate.

Results Of the 3880 cases 157 had TCT abnormality (4.0%). Of the 149 patients who had HPV test results, 112 women (81.2%) received a fresh cycle embryo transfer. Each group had 56 cases. The patients were of similar age and BMI, basic hormone levels, and infertile factors were similar. The gonadotropin use, oocyte retrieval number, clinical pregnancy rate, abortion rate and newborn condition were all similar between groups. Analyses showed neither HPV infection nor HPV hybrid capture (HC) II results affected clinical pregnancy rate after IVF treatments, but the FSH level did.

Conclusion HPV positivity did not appear to impact assisted reproductive technology (ART) success. "Extensive treatment" for HPV before IVF was not recommended because treatment time will increase age and reduce ovarian function, which will lead to inferior IVF outcomes.

语种: 英语
WOS记录号: WOS:000319793800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63010
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Reprod Med Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Yang Rui,Wang Ying,Qiao Jie,et al. Does human papillomavirus infection do harm to in-vitro fertilization outcomes and subsequent pregnancy outcomes?[J]. CHINESE MEDICAL JOURNAL,2013,126(4):683-687.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang Rui]'s Articles
[Wang Ying]'s Articles
[Qiao Jie]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang Rui]‘s Articles
[Wang Ying]‘s Articles
[Qiao Jie]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace