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Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling
Ni, Cheng; Li, Zhengqian; Qian, Min; Zhou, Yang; Wang, Jun; Guo, Xiangyang
关键词Calcineurin Nuclear factor of activated T-cells Isoflurane Cyclosporine A Cognitive impairment
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2015-05-15
DOI10.1016/j.bbrc.2015.03.083
460期:4页:889-895
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
资助者National Natural Science Foundation Of China ; Scientific Research Foundation for Returned Scholars, Peking University Third Hospital ; National Natural Science Foundation Of China ; Scientific Research Foundation for Returned Scholars, Peking University Third Hospital
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]LONG-TERM POTENTIATION ; ALZHEIMERS-DISEASE ; CYCLOSPORINE-A ; NUCLEAR-FACTOR ; AMYLOID-BETA ; IN-VIVO ; INHIBITION ; ACTIVATION ; MEMORY ; APOPTOSIS
英文摘要

Calcineurin (CaN) over-activation constrains synaptic plasticity and memory formation. Upon CaN activation, NFAT imports into the nucleus and guides its downstream genes, which also affect neuronal and synaptic function. Aberrant CaN/NFAT signaling involves in neurotoxicity and cognitive impairment in neurological disorders such as Alzheimer′s disease, but its role in postoperative cognitive dysfunction (POCD) remains uninvestigated. Inhaled anesthetic isoflurane facilitates the development of POCD, and the present study investigated the role of CaN/NFAT signaling in isoflurane induced cognitive impairment of aged rats, and the therapeutic effects of CaN inhibitor cyclosporine A (CsA). The results indicated that hippocampal CaN activity increased and peaked at 6 h after isoflurane exposure, and NFAT, especially NFATc4, imported into the nucleus following CaN activation. Furthermore, phamacological inhibition of CaN by CsA markedly attenuated isoflurane induced aberrant CaN/NFATc4 signaling in the hippocampus, and rescued relevant spatial learning and memory impairment of aged rats. Overall, the study suggests hippocampal CaN/NFAT signaling as the upstream mechanism of isoflurane induced cognitive impairment, and provides potential therapeutic target and possible treatment methods for POCD. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
所属项目编号81400869
资助者National Natural Science Foundation Of China ; Scientific Research Foundation for Returned Scholars, Peking University Third Hospital ; National Natural Science Foundation Of China ; Scientific Research Foundation for Returned Scholars, Peking University Third Hospital
WOS记录号WOS:000356980900001
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63018
专题北京大学第三临床医学院_麻醉科
作者单位Peking Univ, Hosp 3, Dept Anesthesiol, Beijing 100191, Peoples R China
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GB/T 7714
Ni, Cheng,Li, Zhengqian,Qian, Min,et al. Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2015,460(4):889-895.
APA Ni, Cheng,Li, Zhengqian,Qian, Min,Zhou, Yang,Wang, Jun,&Guo, Xiangyang.(2015).Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,460(4),889-895.
MLA Ni, Cheng,et al."Isoflurane induced cognitive impairment in aged rats through hippocampal calcineurin/NFAT signaling".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460.4(2015):889-895.
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