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学科主题: 临床医学
题名:
Citrullinated peptide and its relevance to rheumatoid arthritis: an update
作者: Luban, Stanislav2; Li, Zhan-Guo1
关键词: anti-citrullinated peptide antibodies ; peptidylarginine dearninase ; rheumatoid arthritis
刊名: INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES
发表日期: 2010-10-01
DOI: 10.1111/j.1756-185X.2010.01553.x
卷: 13, 期:4, 页:284-287
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Rheumatology
研究领域[WOS]: Rheumatology
关键词[WOS]: HLA-DRB1 SHARED EPITOPE ; ANTIBODIES ; VIMENTIN ; SUSCEPTIBILITY ; PROTEINS ; ALLELES ; RISK
英文摘要:

Citrullinated peptides in autoimmune diseases have been extensively studied in the last two decades. It is suggested that citrullination and the anti-citrullinated peptide antibodies (ACPA) plays a critical role in initiating inflammatory responses in autoimmune diseases, such as rheumatoid arthritis (RA). The most commonly accepted molecular mechanism for citrullinated peptides/proteins in RA is that the modified antigen resulting from cell damage or uncontrolled apoptosis could evoke an immune response leading to autoantibodies against these peptide or the whole protein. Citrullination of arginine is catalyzed by the enzyme peptidylarginine-deiminase (PAD) in the presence of calcium, changing the positively charged arginine to a polar but neutral citrulline. These citrullinated peptides/proteins and the relevant antibodies (ACPA) are important, not only in initiation of RA, but also in the diagnosis of the disease. In this evidence-based clinical review, we summarize recently published data on peptide citrullination and ACPA gauging the ability of anti-cyclic citrullinated peptide (anti-CCP) antibodies for diagnosis of RA. We also recapitulate results of studies elucidating the mechanism underlying the disease.

语种: 英语
WOS记录号: WOS:000282570200010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63021
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China
2.Univ Calif San Diego, Interdisciplinary Bioinformat & Syst Biol Program, La Jolla, CA 92093 USA

Recommended Citation:
Luban, Stanislav,Li, Zhan-Guo. Citrullinated peptide and its relevance to rheumatoid arthritis: an update[J]. INTERNATIONAL JOURNAL OF RHEUMATIC DISEASES,2010,13(4):284-287.
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