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学科主题药学
Synthesis of PNA monomers and dimers by Ugi four-component reaction
Xu, P; Zhang, T; Wang, WH; Zou, XM; Zhang, X; Fu, YQ
关键词peptide nucleic acids (PNA) condensation isocyanide Ugi four-component reaction
刊名SYNTHESIS-STUTTGART
2003-06-01
8页:1171-1176
收录类别SCI ; IC ; CCR
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Organic
研究领域[WOS]Chemistry
关键词[WOS]PEPTIDE NUCLEIC-ACIDS ; MULTI COMPONENT REACTIONS ; BUILDING-BLOCKS ; DNA ; ANALOGS ; POLYAMIDE ; THYMINE ; STRAND
英文摘要

Peptide nucleic acids (PNA) have received great attention as tools in molecular biology and biotechnology, diagnostic agents. and potential antisense drugs. Many derivatives and analogues of PNA were designed and prepared to improve their physicochemical and biological properties. In most cases, PNA oligomers were synthesized by peptide synthesis from N-protected monomers. In this work. a new method to obtain PNA monomers and PNA chain prolongation by Ugi four-component condensation reaction was tested by synthesizing PNA monomers and dimers. This method differs from classical peptide chemistry in that no prior preparation of PNA monomers is needed as they are built up along with the extension of chain. The synthesis of the key component isocyanide is also presented.

语种英语
WOS记录号WOS:000183543700005
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63022
专题北京大学药学院_药物化学系
作者单位Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Xu, P,Zhang, T,Wang, WH,et al. Synthesis of PNA monomers and dimers by Ugi four-component reaction[J]. SYNTHESIS-STUTTGART,2003(8):1171-1176.
APA Xu, P,Zhang, T,Wang, WH,Zou, XM,Zhang, X,&Fu, YQ.(2003).Synthesis of PNA monomers and dimers by Ugi four-component reaction.SYNTHESIS-STUTTGART(8),1171-1176.
MLA Xu, P,et al."Synthesis of PNA monomers and dimers by Ugi four-component reaction".SYNTHESIS-STUTTGART .8(2003):1171-1176.
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