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学科主题: 药学
题名:
Synthesis of PNA monomers and dimers by Ugi four-component reaction
作者: Xu, P; Zhang, T; Wang, WH; Zou, XM; Zhang, X; Fu, YQ
关键词: peptide nucleic acids (PNA) ; condensation ; isocyanide ; Ugi four-component reaction
刊名: SYNTHESIS-STUTTGART
发表日期: 2003-06-01
期: 8, 页:1171-1176
收录类别: SCI ; IC ; CCR
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Organic
研究领域[WOS]: Chemistry
关键词[WOS]: PEPTIDE NUCLEIC-ACIDS ; MULTI COMPONENT REACTIONS ; BUILDING-BLOCKS ; DNA ; ANALOGS ; POLYAMIDE ; THYMINE ; STRAND
英文摘要:

Peptide nucleic acids (PNA) have received great attention as tools in molecular biology and biotechnology, diagnostic agents. and potential antisense drugs. Many derivatives and analogues of PNA were designed and prepared to improve their physicochemical and biological properties. In most cases, PNA oligomers were synthesized by peptide synthesis from N-protected monomers. In this work. a new method to obtain PNA monomers and PNA chain prolongation by Ugi four-component condensation reaction was tested by synthesizing PNA monomers and dimers. This method differs from classical peptide chemistry in that no prior preparation of PNA monomers is needed as they are built up along with the extension of chain. The synthesis of the key component isocyanide is also presented.

语种: 英语
WOS记录号: WOS:000183543700005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63022
Appears in Collections:北京大学药学院_药物化学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Med Chem, Beijing 100083, Peoples R China

Recommended Citation:
Xu, P,Zhang, T,Wang, WH,et al. Synthesis of PNA monomers and dimers by Ugi four-component reaction[J]. SYNTHESIS-STUTTGART,2003(8):1171-1176.
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