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学科主题基础医学
Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway
Bai, Yun1; Cui, Ming2; Meng, Zhijun1; Shen, Li1; He, Qihua1; Zhang, Xiaoyan1; Chen, Fengrong2; Xiao, Junjun1
关键词Angiopoetin-1 Neural progenitor cells Neuronal differentiation Neurogenesis Tie2 Akt
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-01-09
DOI10.1016/j.bbrc.2008.11.052
378期:2页:296-301
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]ENDOTHELIAL GROWTH-FACTOR ; CENTRAL-NERVOUS-SYSTEM ; NEUROGENESIS ; SURVIVAL ; ISCHEMIA ; PROLIFERATION ; APOPTOSIS ; OUTGROWTH ; PROTECTS ; RECEPTOR
英文摘要

In regions of adult neurogenesis, neural progenitor cells (NPCs) are found in close proximity to blood vessels within a so-called ′vascular niche′. Neurogenesis is linked to angiogenesis via certain growth factors. We propose that angiopoietin-1 (Ang1), which is similar to VEGF, has a unique role in neurogenesis independent of its role in angiogenesis. In this study, primary cultures of NPCs were transduced with recombinant: adenoviruses expressing Ang1 and induced to differentiate With dibutyryl cyclic AMP (dbcAMP). Neuronal differentiation was evaluated by quantitative PCR, immunofluorescence microscopy and Western blot analysis. The results show that ectopic expression of Ang1 promotes neuronal differentiation and neurite outgrowth in NPCs, while this effect was blocked by the presence of anti-Tie2 receptor antibody or the P13-K inhibitor, LY294002. Our results Suggest that Ang1, identified originally as in angiogenic factor, can also stimulate in vitro neurogenesis in NPCs through the Akt pathway. (c) 2008 Elsevier Inc. All fights reserved.

语种英语
WOS记录号WOS:000262063100030
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63025
专题北京大学基础医学院_细胞生物学系
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
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GB/T 7714
Bai, Yun,Cui, Ming,Meng, Zhijun,et al. Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,378(2):296-301.
APA Bai, Yun.,Cui, Ming.,Meng, Zhijun.,Shen, Li.,He, Qihua.,...&Xiao, Junjun.(2009).Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,378(2),296-301.
MLA Bai, Yun,et al."Ectopic expression of angiopoietin-1 promotes neuronal differentiation in neural progenitor cells through the Akt pathway".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 378.2(2009):296-301.
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