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Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats
Liu, WJ; Xin, ZC; Xin, H; Yuan, YM; Tian, L; Guo, YL
关键词icariin corpus cavernosm intracavernosal pressure nitric oxide synthase erectile dysfunction
刊名ASIAN JOURNAL OF ANDROLOGY
2005-12-01
DOI10.1111/j.1745-7262.2005.00066.x
7期:4页:381-388
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Andrology ; Urology & Nephrology
研究领域[WOS]Endocrinology & Metabolism ; Urology & Nephrology
关键词[WOS]CORPUS CAVERNOSUM ; SMOOTH-MUSCLE ; PENIS ; REPLACEMENT ; MODEL
英文摘要

Aim: To investigate the effect of icariin on erectile function and the expression of nitric oxide synthase (NOS) isoforms in castrated rats. Methods: Thirty-two adult male Wistar rats were randomly divided into one sham-operated group (A) and three castrated groups (B, C and D). One week after surgery, rats were treated with normal saline (groups A and B) or oral icariin (1 mg/[kg(.)day] for group C and 5 mg/[kg(.)day] for group D) for 4 weeks. One week after treatment, the erectile function of the rats was assessed by measuring intracavernosal pressure (ICP) during electrostimulation of the cavernosal nerve. The serum testosterone (ST) levels, the percent of smooth muscle (PSM) in trabecular tissue, and the expression of mRNA and proteins of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS), endothelial nitric oxide synthase (eNOS) and phosphodiesterase V (PDE5) in corpus cavernosum (CC) were also evaluated. Results: ICP, PSM, ST and the expression of nNOS, iNOS, eNOS and PDE5 were significantly decreased in group B compared with those in group A (P < 0.01). However, ICP, PSM and the expression of nNOS and iNOS were increased in groups C and D compared with those in group B (P < 0.05). Changes in ST and the expression of eNOS and PDE5 were not significant (P > 0.05) in groups C and D compared with those in group B. Conclusion: Oral treatment with icariin (> 98.6 % purity) for 4 weeks potentially improves erectile function. This effect is correlated with an increase in PSM and the expression of certain NOS in the CC of castrated rats. These results suggest that icariin may have a therapeutic effect on erectile dysfunction.

语种英语
WOS记录号WOS:000233829600006
引用统计
被引频次:62[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63036
专题北京大学第一临床医学院_男科中心
作者单位Peking Univ, Hosp 1, Androl Ctr, Beijing 100009, Peoples R China
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GB/T 7714
Liu, WJ,Xin, ZC,Xin, H,et al. Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats[J]. ASIAN JOURNAL OF ANDROLOGY,2005,7(4):381-388.
APA Liu, WJ,Xin, ZC,Xin, H,Yuan, YM,Tian, L,&Guo, YL.(2005).Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats.ASIAN JOURNAL OF ANDROLOGY,7(4),381-388.
MLA Liu, WJ,et al."Effects of icariin on erectile function and expression of nitric oxide synthase isoforms in castrated rats".ASIAN JOURNAL OF ANDROLOGY 7.4(2005):381-388.
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