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学科主题: 精神卫生
题名:
Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology
作者: Zhang, XY; Zhou, DF; Zhang, PY; Wu, GY; Cao, LY; Shen, YC
关键词: schizophrenia ; interleukin ; immune ; psychopathology ; symptom
刊名: SCHIZOPHRENIA RESEARCH
发表日期: 2002-10-01
卷: 57, 期:2-3, 页:247-258
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: NECROSIS-FACTOR-ALPHA ; INFLAMMATORY RESPONSE SYSTEM ; SOLUBLE IL-2 RECEPTOR ; PLASMA-LEVELS ; CIRCULATING LEVELS ; INTERFERON-GAMMA ; DRUG-FREE ; CYTOKINES ; AUTOIMMUNITY ; CLOZAPINE
英文摘要:

Cytokines have been one of the recent focal points of immunological research in schizophrenia. The present study was to assess the serum levels of some of interleukins in schizophrenia and their relationships with the psychopathological parameters. Seventy physically healthy Chinese patients, who met DSM-III-R criteria for schizophrenia and who were drug-free for at least 2 weeks, were compared with 30 age- and sex-matched Chinese normal controls. The psychopathology of schizophrenia was assessed by the Positive and Negative Syndrome Scale (PANSS). Serum levels of IL-6 and IL-8 were measured by sandwich enzyme-linked immunosorbent assay (ELISA), and serum IL-2 level was assayed by radioimmunometric assay (RIA), Serum levels of IL-2, IL-6 and IL-8 were significantly elevated in patients with a chronic form of schizophrenia (all p < 0.05). There was a significant inverse relationship between IL-2 level and the PANSS positive subscale P (r= - 0.31, p = 0.006) and a significant positive correlation between IL-8 level and PANSS negative subscale N (r=0.25, p=0.036) in schizophrenic patients. In control subjects, a significant and positive relationship between serum IL-2 and IL-6 (r = 0.513, p = 0.004) was noted, whereas, there was a significant and negative relationship between IL-2 and IL-8 in schizophrenic patients (r= - 0.28, p = 0,02). Our data confirms and supports the view that immune disturbance is involved in schizophrenia, which is compatible with the possibility that Chinese schizophrenic patients have an ongoing autoimmune process, This immune disturbance is related to the subgroup of schizophrenic patients with characteristic clinical variables. The dysfunction of interaction or inter-adjustment between different cytokines may exist in schizophrenic patients. (C) 2002 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000178358100014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63037
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Beijing Huilongguan Hosp, Beijing, Peoples R China
2.Beijing Med Univ, Inst Mental Hlth, Beijing 100085, Peoples R China

Recommended Citation:
Zhang, XY,Zhou, DF,Zhang, PY,et al. Elevated interleukin-2, interleukin-6 and interleukin-8 serum levels in neuroleptic-free schizophrenia: association with psychopathology[J]. SCHIZOPHRENIA RESEARCH,2002,57(2-3):247-258.
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