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学科主题: 基础医学
题名:
Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(II) Complex with Ligand N,N ′-Bis(4-chlorobenzyl) propane-1,2-diamine
作者: Yang Shu-Ping1; Han Li-Jun2; Pan Yan3,4; Wang Da-Qi5; Zhao Cui1; Wang Bo1
关键词: Copper(II) complex ; N,N &prime ; -bis(4-chlorobenzyl) propane-1,2-diamine ; Crystal structure ; Antibacterial activity ; Bovine serum albumin(BSA)
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2012-01-10
DOI: 10.3969/j.issn.0251-0790.2012.01.002
卷: 33, 期:1, 页:14-21
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: BOVINE SERUM-ALBUMIN ; SCHIFF-BASE ; FLUORESCENCE
英文摘要:

A new copper (II) complex with ligand N, N′-bis (4-chlorobenzyl) propane-1, 2-diamine, [CuCl(C17H20C12N2)2]center dot NH4 center dot Cl-2, has been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffraction methods. The crystal of copper(II) complex belongs to triclinic system with space group P (1) over bar, a = 1. 35222(16) nm, b = 1. 37899 (17) nm, c = 1. 39806 (19) nm; alpha = 60. 954 (1)degrees, beta=87. 502(2)degrees, gamma=65. 970 (1)degrees, V=2. 0424 (4) nm(3), D-c=1. 357 g/cm(3), Z=2, F(000) = 862, R-1= 0. 0925, wR(2)=0. 2668[I>2 sigma(I)], S=1. 001. The copper(II) atom of the metal center in complex is five-coordinated by four N atoms from two ligand molecules and a terminal Cl atom, and the coordination polyhedron around the Cu atom can be described as a slightly distorted square pyramid-geometry with a distortion index 7 value of 0. 04 (1). The complex exhibited good antibacterial properties and the interaction of complex and bovine serum albumin(BSA) was investigated by fluorescence spectroscopy at different temperatures. The results indicated that the complex caused the fluorescence quenching of BSA through a static quenching procedure. The binding constants(K-a), the number of binding sites(n approximate to 1), and corresponding thermodynamic parameters enthalpy change(Delta H>0), entropy change (Delta S>0), Gibbs free energy change(Delta G<0), between complex and BSA at different temperatures were calculated. The primary binding pattern between complex and BSA was interpreted as hydrophobic interaction. The binding average distance r between the donor(BSA) and acceptor(complex) was obtained to be 2. 56 nm based on the Foster′s theory, which indicates the energy transfer can occur from BSA to complex with high probability.

语种: 中文
WOS记录号: WOS:000299715900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63038
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: 1.Huaihai Inst Technol, Sch Chem Engn, Lianyungang 222005, Peoples R China
2.State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Huaihai Inst Technol, Sch Math & Sci, Lianyungang 222005, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
5.Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Peoples R China

Recommended Citation:
Yang Shu-Ping,Han Li-Jun,Pan Yan,et al. Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(II) Complex with Ligand N,N &prime;-Bis(4-chlorobenzyl) propane-1,2-diamine[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2012,33(1):14-21.
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