IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(II) Complex with Ligand N,N ′-Bis(4-chlorobenzyl) propane-1,2-diamine
Yang Shu-Ping1; Han Li-Jun2; Pan Yan3,4; Wang Da-Qi5; Zhao Cui1; Wang Bo1
关键词Copper(II) complex N,N &prime -bis(4-chlorobenzyl) propane-1,2-diamine Crystal structure Antibacterial activity Bovine serum albumin(BSA)
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2012-01-10
DOI10.3969/j.issn.0251-0790.2012.01.002
33期:1页:14-21
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]BOVINE SERUM-ALBUMIN ; SCHIFF-BASE ; FLUORESCENCE
英文摘要

A new copper (II) complex with ligand N, N′-bis (4-chlorobenzyl) propane-1, 2-diamine, [CuCl(C17H20C12N2)2]center dot NH4 center dot Cl-2, has been synthesized and characterized by elemental analysis, IR spectra and single crystal X-ray diffraction methods. The crystal of copper(II) complex belongs to triclinic system with space group P (1) over bar, a = 1. 35222(16) nm, b = 1. 37899 (17) nm, c = 1. 39806 (19) nm; alpha = 60. 954 (1)degrees, beta=87. 502(2)degrees, gamma=65. 970 (1)degrees, V=2. 0424 (4) nm(3), D-c=1. 357 g/cm(3), Z=2, F(000) = 862, R-1= 0. 0925, wR(2)=0. 2668[I>2 sigma(I)], S=1. 001. The copper(II) atom of the metal center in complex is five-coordinated by four N atoms from two ligand molecules and a terminal Cl atom, and the coordination polyhedron around the Cu atom can be described as a slightly distorted square pyramid-geometry with a distortion index 7 value of 0. 04 (1). The complex exhibited good antibacterial properties and the interaction of complex and bovine serum albumin(BSA) was investigated by fluorescence spectroscopy at different temperatures. The results indicated that the complex caused the fluorescence quenching of BSA through a static quenching procedure. The binding constants(K-a), the number of binding sites(n approximate to 1), and corresponding thermodynamic parameters enthalpy change(Delta H>0), entropy change (Delta S>0), Gibbs free energy change(Delta G<0), between complex and BSA at different temperatures were calculated. The primary binding pattern between complex and BSA was interpreted as hydrophobic interaction. The binding average distance r between the donor(BSA) and acceptor(complex) was obtained to be 2. 56 nm based on the Foster′s theory, which indicates the energy transfer can occur from BSA to complex with high probability.

语种中文
WOS记录号WOS:000299715900002
Citation statistics
Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63038
Collection北京大学基础医学院_药理学系
北京大学基础医学院
作者单位1.Huaihai Inst Technol, Sch Chem Engn, Lianyungang 222005, Peoples R China
2.State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Huaihai Inst Technol, Sch Math & Sci, Lianyungang 222005, Peoples R China
4.Peking Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing 100191, Peoples R China
5.Liaocheng Univ, Sch Chem & Chem Engn, Liaocheng 252059, Peoples R China
Recommended Citation
GB/T 7714
Yang Shu-Ping,Han Li-Jun,Pan Yan,et al. Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(II) Complex with Ligand N,N &prime;-Bis(4-chlorobenzyl) propane-1,2-diamine[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2012,33(1):14-21.
APA Yang Shu-Ping,Han Li-Jun,Pan Yan,Wang Da-Qi,Zhao Cui,&Wang Bo.(2012).Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(II) Complex with Ligand N,N ′-Bis(4-chlorobenzyl) propane-1,2-diamine.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,33(1),14-21.
MLA Yang Shu-Ping,et al."Synthesis, Crystal Structure, Antibacterial Activity and Interaction with BSA of Copper(II) Complex with Ligand N,N ′-Bis(4-chlorobenzyl) propane-1,2-diamine".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 33.1(2012):14-21.
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