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Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice
Liao, You-Jiao1; Zhai, Hai-Feng2; Zhang, Bing1; Duan, Tian-Xuan1; Huang, Jian-Mei1
关键词anxiolytic sedative dehydroeffusol phenanthrene Juncus effusus Juncaceae
刊名PLANTA MEDICA
2011-03-01
DOI10.1055/s-0030-1250517
77期:5页:416-420
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]GENERALIZED ANXIETY DISORDER ; PHENANTHRENES ; DERIVATIVES ; GLUCOSIDES
英文摘要

Dehydroeffusol, a phenanthrene isolated from Juncus effusus L., possesses characteristic anxiolytic and sedative properties, as determined by an array of behavioral tests in mice. In the elevated plus-maze test, dehydroeffusol significantly increased the number of entries into the open arms and the time the mice spent in these arms in a dose-dependent manner, with a minimum effective dose of 2.5 mg/kg. Dehydroeffusol also significantly increased the head-dips of mice in the hole-board test in a dose-dependent manner, with a minimum effective dose of 5 mg/kg. Dehydroeffusol reduced mouse locomotion in the open-field test with a minimum effective dose of 5 mg/kg. In the rota-rod test, 1-5 mg/kg dehydroeffusol did not decrease the fall-down time of mice. The above results confirm that dehydroeffusol possesses anxiolytic and sedative properties and does not affect the general movement coordination of mice. This suggests that dehydroeffusol is a novel anxiolytic chemical derived from herbal medicines.

语种英语
WOS记录号WOS:000288847600002
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被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63045
专题中国药物依赖性研究所
北京大学公共卫生学院_北京大学儿童青少年卫生研究所
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
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GB/T 7714
Liao, You-Jiao,Zhai, Hai-Feng,Zhang, Bing,et al. Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice[J]. PLANTA MEDICA,2011,77(5):416-420.
APA Liao, You-Jiao,Zhai, Hai-Feng,Zhang, Bing,Duan, Tian-Xuan,&Huang, Jian-Mei.(2011).Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice.PLANTA MEDICA,77(5),416-420.
MLA Liao, You-Jiao,et al."Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice".PLANTA MEDICA 77.5(2011):416-420.
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