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学科主题: 药物依赖
题名:
Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice
作者: Liao, You-Jiao1; Zhai, Hai-Feng2; Zhang, Bing1; Duan, Tian-Xuan1; Huang, Jian-Mei1
关键词: anxiolytic ; sedative ; dehydroeffusol ; phenanthrene ; Juncus effusus ; Juncaceae
刊名: PLANTA MEDICA
发表日期: 2011-03-01
DOI: 10.1055/s-0030-1250517
卷: 77, 期:5, 页:416-420
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: GENERALIZED ANXIETY DISORDER ; PHENANTHRENES ; DERIVATIVES ; GLUCOSIDES
英文摘要:

Dehydroeffusol, a phenanthrene isolated from Juncus effusus L., possesses characteristic anxiolytic and sedative properties, as determined by an array of behavioral tests in mice. In the elevated plus-maze test, dehydroeffusol significantly increased the number of entries into the open arms and the time the mice spent in these arms in a dose-dependent manner, with a minimum effective dose of 2.5 mg/kg. Dehydroeffusol also significantly increased the head-dips of mice in the hole-board test in a dose-dependent manner, with a minimum effective dose of 5 mg/kg. Dehydroeffusol reduced mouse locomotion in the open-field test with a minimum effective dose of 5 mg/kg. In the rota-rod test, 1-5 mg/kg dehydroeffusol did not decrease the fall-down time of mice. The above results confirm that dehydroeffusol possesses anxiolytic and sedative properties and does not affect the general movement coordination of mice. This suggests that dehydroeffusol is a novel anxiolytic chemical derived from herbal medicines.

语种: 英语
所属项目编号: 2007CB512605
项目资助者: 973 Program ; Program for New Century Excellent Talents in University of China
WOS记录号: WOS:000288847600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63045
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Peking Univ, Dept Neuropharmacol, Natl Inst Drug Dependence, Beijing 100871, Peoples R China

Recommended Citation:
Liao, You-Jiao,Zhai, Hai-Feng,Zhang, Bing,et al. Anxiolytic and Sedative Effects of Dehydroeffusol from Juncus effusus in Mice[J]. PLANTA MEDICA,2011,77(5):416-420.
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