|Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects|
|Yang, Yuan1; Zhang, Fan2; Ding, Rongjing3; Wang, Yang4; Lei, Han1; Hu, Dayi1|
|关键词||Coronary artery disease ADIPOQ gene polymorphism Meta analysis|
|WOS标题词||Science & Technology|
|类目[WOS]||Hematology ; Peripheral Vascular Disease|
|研究领域[WOS]||Hematology ; Cardiovascular System & Cardiology|
|关键词[WOS]||SINGLE-NUCLEOTIDE POLYMORPHISMS ; ADIPONECTIN GENE ; CARDIOVASCULAR-DISEASE ; MYOCARDIAL-INFARCTION ; INSULIN-RESISTANCE ; METABOLIC SYNDROME ; DIABETES-MELLITUS ; HEART-DISEASE ; VARIANTS ; LOCUS|
Introduction: Coronary artery disease (CAD) is one of the most common cardiovascular diseases and is a major cause of morbidity and mortality worldwide. Various researchers have investigated the role of ADIPOQ gene in the risk of CAD, yet their results have been inconsistent.
Methods: To evaluate the association between ADIPOQ genetic polymorphisms and CAD risk, relevant studies published before October 2011 were identified by searching PubMed and EMBASE. Studies were selected using previously defined criteria. The strength of the relationship between the four single nucleotide polymorphisms (SNPs) of the ADIPOQ gene and CAD risk was assessed using odds ratios (ORs).
Results: A total of 12 465 subjects from 17 case-control studies were identified in the present study. Based on the relevant studies, it was determined that the risk of CAD was not associated with rs2241766 in any genetic model. Increased risk of CAD was associated with rs266729 in allele contrast (1.11, [1.03, 1.20]) and dominant genetic model (1.15, 95% CI: [1.05, 1.27]); increased risk of CAD was also associated with rs822395 in additive (1.63, 95% CI: [1.19, 2.22]) and recessive genetic model (1.71, 95% CI: [1.27, 2.30]). It was further determined that the rs1501299 polymorphism reduced the risk of CAD in the additive (0.80, 95% CI: [0.67, 0.94]) and recessive genetic model (0.81, 95% CI: [0.68, 0.95]). In the stratified analysis, significant associations were found in Asian subjects for rs266729 and in Caucasian subjects for rs1501299.
Conclusion: There is an association between ADIPOQ gene polymorphisms and CAD risk. Different SNPs of the ADIPOQ gene have different associations with CAD risk, and appear to increase risk in individuals of Asian ethnicity while decrease the CAD risk in Caucasians. However, the overall strength of association was mild to moderate. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
|作者单位||1.Chongqing Med Univ, Affiliated Hosp 1, Dept Cardiol, Chongqing 400016, Peoples R China|
2.Chongqing Med Univ, Sch Publ Hlth & Hlth Management, Chongqing 400016, Peoples R China
3.Peking Univ Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China
4.Chongqing Med Univ, China Network Effect Hlth Care Res Consortium, Chongqing 400016, Peoples R China
|Yang, Yuan,Zhang, Fan,Ding, Rongjing,et al. Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects[J]. THROMBOSIS RESEARCH,2012,130(1):58-64.|
|APA||Yang, Yuan,Zhang, Fan,Ding, Rongjing,Wang, Yang,Lei, Han,&Hu, Dayi.(2012).Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects.THROMBOSIS RESEARCH,130(1),58-64.|
|MLA||Yang, Yuan,et al."Association of ADIPOQ gene polymorphisms and coronary artery disease risk: A meta-analysis based on 12 465 subjects".THROMBOSIS RESEARCH 130.1(2012):58-64.|