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DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats
Sun, Shuang-Yong1,2; An, Chun-Na1,2; Pu, Xiao-Ping1,2
关键词DJ-1 protein Parkinson&prime s disease 6-OHDA MG-132 SOD2 alpha-Synuclein
刊名BRAIN RESEARCH BULLETIN
2012-09-01
DOI10.1016/j.brainresbull.2012.05.013
88期:6页:609-616
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PARKINSONS-DISEASE ; SUPEROXIDE-DISMUTASE ; OXIDATIVE STRESS ; MODEL ; EXPRESSION ; DEGENERATION ; TOXICITY ; CELLS ; MICE ; NEURODEGENERATION
英文摘要

Parkinson disease (PD) is the second most common neurodegenerative disease, and it cannot be completely cured by current medications. In this study, DJ-1 protein was administrated into medial forebrain bundle of PD model rats those had been microinjected with 6-hydroxydopamine (6-OHDA) or MG-132. We found that DJ-1 protein could reduce apomorphine-induced rotations, inhibit reduction of dopamine contents and tyrosine hydroxylase levels in the striatum, and decrease dopaminergic neuron death in the substantia nigra. In 6-OHDA lesioned rats, uncoupling protein-4, uncoupling protein-5 and superoxide dismutase-2 (SOD2) mRNA and SOD2 protein were increased when DJ-1 protein was co-injected. Simultaneously, administration of DJ-1 protein reduced a-synuclein and hypoxia-inducible factor 1 alpha mRNA and alpha-synuclein protein in MG-132 lesioned rats. Therefore, DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting a-synuclein expression. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000308049300010
项目编号20090001110069
资助机构Ministry of Education in China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63055
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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Sun, Shuang-Yong,An, Chun-Na,Pu, Xiao-Ping. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats[J]. BRAIN RESEARCH BULLETIN,2012,88(6):609-616.
APA Sun, Shuang-Yong,An, Chun-Na,&Pu, Xiao-Ping.(2012).DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats.BRAIN RESEARCH BULLETIN,88(6),609-616.
MLA Sun, Shuang-Yong,et al."DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats".BRAIN RESEARCH BULLETIN 88.6(2012):609-616.
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