北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats
作者: Sun, Shuang-Yong1,2; An, Chun-Na1,2; Pu, Xiao-Ping1,2
关键词: DJ-1 protein ; Parkinson&prime ; s disease ; 6-OHDA ; MG-132 ; SOD2 ; alpha-Synuclein
刊名: BRAIN RESEARCH BULLETIN
发表日期: 2012-09-01
DOI: 10.1016/j.brainresbull.2012.05.013
卷: 88, 期:6, 页:609-616
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: PARKINSONS-DISEASE ; SUPEROXIDE-DISMUTASE ; OXIDATIVE STRESS ; MODEL ; EXPRESSION ; DEGENERATION ; TOXICITY ; CELLS ; MICE ; NEURODEGENERATION
英文摘要:

Parkinson disease (PD) is the second most common neurodegenerative disease, and it cannot be completely cured by current medications. In this study, DJ-1 protein was administrated into medial forebrain bundle of PD model rats those had been microinjected with 6-hydroxydopamine (6-OHDA) or MG-132. We found that DJ-1 protein could reduce apomorphine-induced rotations, inhibit reduction of dopamine contents and tyrosine hydroxylase levels in the striatum, and decrease dopaminergic neuron death in the substantia nigra. In 6-OHDA lesioned rats, uncoupling protein-4, uncoupling protein-5 and superoxide dismutase-2 (SOD2) mRNA and SOD2 protein were increased when DJ-1 protein was co-injected. Simultaneously, administration of DJ-1 protein reduced a-synuclein and hypoxia-inducible factor 1 alpha mRNA and alpha-synuclein protein in MG-132 lesioned rats. Therefore, DJ-1 protein protected dopaminergic neurons in two PD model rats by increasing antioxidant capacity and inhibiting a-synuclein expression. (C) 2012 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 20090001110069
项目资助者: Ministry of Education in China
WOS记录号: WOS:000308049300010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63055
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Shuang-Yong,An, Chun-Na,Pu, Xiao-Ping. DJ-1 protein protects dopaminergic neurons against 6-OHDA/MG-132-induced neurotoxicity in rats[J]. BRAIN RESEARCH BULLETIN,2012,88(6):609-616.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Sun, Shuang-Yong]'s Articles
[An, Chun-Na]'s Articles
[Pu, Xiao-Ping]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Sun, Shuang-Yong]‘s Articles
[An, Chun-Na]‘s Articles
[Pu, Xiao-Ping]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2018  北京大学医学部 - Feedback
Powered by CSpace