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High prevalence of obstructive sleep apnea in Marfan′s syndrome
Mo Li1; He Quanying3; Wang Yinna4; Dong Birong1; He Jinhan2
关键词sleep apnea Marfan&prime s syndrome epidemiology craniofacial abnormalities therapy
刊名CHINESE MEDICAL JOURNAL
2014-09-05
DOI10.3760/cma.j.issn.0366-6999.20140660
127期:17页:3150-3155
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]POSITIVE AIRWAY PRESSURE ; AORTIC DILATATION ; BLOOD-PRESSURE ; DISEASE ; ASSOCIATION ; HYPOPNEA ; HEALTH ; METAANALYSIS ; PROGRESSION ; RESISTANCE
英文摘要

Objective To review the current evidence about the prevalence of obstructive sleep apnea in patients with Marfan′s syndrome, and discuss some proposed potential mechanisms for this relationship.

Data sources The data in this review were mainly from Medline and PubMed articles published in English from 1990 to 2013. The search term was "Marfan′s syndrome and sleep apnea".

Study selection Clinical evidence about the epidemiology of obstructive sleep apnea in patients with Marfan′s syndrome; the mechanism that causes obstructive sleep apnea; interventional therapy for patients with Marfan′s syndrome, and coexisting obstructive sleep apnea.

Results A high prevalence of obstructive sleep apnea exists in patients with Marfan′s syndrome. The potential reasons are craniofacial abnormalities and lax upper airway muscles, which lead to high nasal airway resistance and upper airway collapse. Obstructive sleep apnea mechanically deteriorates aortic dilatation and accelerates progression of aortic aneurysms. The condition is reversible and rapid maxillary expansion and adequate continuous positive airway pressure therapy are possible effective therapies to delay the expansion of aortic diameter in patients with Marfan′s syndrome.

Conclusions Obstructive sleep apnea is strongly associated with Marfan′s syndrome. Craniofacial abnormalities and lax upper airway are the main mechanisms. Untreated obstructive sleep apnea accelerates progression of aortic dissection and rupture. Effective therapies for obstructive sleep apnea could postpone the aortic dilatation in patients with Marfan′s syndrome.

语种英语
WOS记录号WOS:000343337100022
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63056
专题北京大学第二临床医学院
作者单位1.Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Chengdu 610041, Sichuan, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Pharm, Chengdu 610041, Sichuan, Peoples R China
3.Peking Univ, Dept Resp & Crit Care Med, Peoples Hosp, Beijing 100044, Peoples R China
4.Univ Pittsburgh, Sch Med, Vasc Med Inst, Pittsburgh, PA 15261 USA
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GB/T 7714
Mo Li,He Quanying,Wang Yinna,et al. High prevalence of obstructive sleep apnea in Marfan′s syndrome[J]. CHINESE MEDICAL JOURNAL,2014,127(17):3150-3155.
APA Mo Li,He Quanying,Wang Yinna,Dong Birong,&He Jinhan.(2014).High prevalence of obstructive sleep apnea in Marfan′s syndrome.CHINESE MEDICAL JOURNAL,127(17),3150-3155.
MLA Mo Li,et al."High prevalence of obstructive sleep apnea in Marfan′s syndrome".CHINESE MEDICAL JOURNAL 127.17(2014):3150-3155.
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