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学科主题: 临床医学
题名:
High prevalence of obstructive sleep apnea in Marfan′s syndrome
作者: Mo Li1; He Quanying3; Wang Yinna4; Dong Birong1; He Jinhan2
关键词: sleep apnea ; Marfan&prime ; s syndrome ; epidemiology ; craniofacial abnormalities ; therapy
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2014-09-05
DOI: 10.3760/cma.j.issn.0366-6999.20140660
卷: 127, 期:17, 页:3150-3155
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: POSITIVE AIRWAY PRESSURE ; AORTIC DILATATION ; BLOOD-PRESSURE ; DISEASE ; ASSOCIATION ; HYPOPNEA ; HEALTH ; METAANALYSIS ; PROGRESSION ; RESISTANCE
英文摘要:

Objective To review the current evidence about the prevalence of obstructive sleep apnea in patients with Marfan′s syndrome, and discuss some proposed potential mechanisms for this relationship.

Data sources The data in this review were mainly from Medline and PubMed articles published in English from 1990 to 2013. The search term was "Marfan′s syndrome and sleep apnea".

Study selection Clinical evidence about the epidemiology of obstructive sleep apnea in patients with Marfan′s syndrome; the mechanism that causes obstructive sleep apnea; interventional therapy for patients with Marfan′s syndrome, and coexisting obstructive sleep apnea.

Results A high prevalence of obstructive sleep apnea exists in patients with Marfan′s syndrome. The potential reasons are craniofacial abnormalities and lax upper airway muscles, which lead to high nasal airway resistance and upper airway collapse. Obstructive sleep apnea mechanically deteriorates aortic dilatation and accelerates progression of aortic aneurysms. The condition is reversible and rapid maxillary expansion and adequate continuous positive airway pressure therapy are possible effective therapies to delay the expansion of aortic diameter in patients with Marfan′s syndrome.

Conclusions Obstructive sleep apnea is strongly associated with Marfan′s syndrome. Craniofacial abnormalities and lax upper airway are the main mechanisms. Untreated obstructive sleep apnea accelerates progression of aortic dissection and rupture. Effective therapies for obstructive sleep apnea could postpone the aortic dilatation in patients with Marfan′s syndrome.

语种: 英语
所属项目编号: 81270926 ; 2013SCU04A17 ; GB2013101
项目资助者: National Natural Science Foundation of China ; Outstanding Scholar Foundation of Sichuan University ; Cadres Health Care Committee Foundation of Health Department, Sichuan Province
WOS记录号: WOS:000343337100022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63056
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Sichuan Univ, West China Hosp, Ctr Gerontol & Geriatr, Chengdu 610041, Sichuan, Peoples R China
2.Sichuan Univ, West China Hosp, Dept Pharm, Chengdu 610041, Sichuan, Peoples R China
3.Peking Univ, Dept Resp & Crit Care Med, Peoples Hosp, Beijing 100044, Peoples R China
4.Univ Pittsburgh, Sch Med, Vasc Med Inst, Pittsburgh, PA 15261 USA

Recommended Citation:
Mo Li,He Quanying,Wang Yinna,et al. High prevalence of obstructive sleep apnea in Marfan′s syndrome[J]. CHINESE MEDICAL JOURNAL,2014,127(17):3150-3155.
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