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学科主题: 临床医学
题名:
Association of GALNT3 gene polymorphisms with bone mineral density in Chinese postmenopausal women: the Peking Vertebral Fracture study
作者: Li, Nan1,2; Wang, Xiran3; Jiang, Yan2; Wang, Wenbo4; Huang, Wei5; Zheng, Xin6; Wang, Qiuping7; Ning, Zhiwei8; Pei, Yu1; Li, Chunlin1; Nie, Min2; Li, Mei2; Wang, Ou2; Xing, Xiaoping2; He, Shuli2; Yu, Wei9; Lin, Qiang9; Xu, Ling10; Xia, Weibo2
关键词: GALNT3 ; Bone mineral density ; Fracture ; Single nucleotide polymorphisms
刊名: MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
发表日期: 2014-05-01
DOI: 10.1097/GME.0b013e3182a34981
卷: 21, 期:5, 页:515-521
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: KLOTHO GENE ; TWIN ; OSTEOPOROSIS ; RISK ; MASS ; EPIDEMIOLOGY ; DETERMINANTS ; RECEPTOR ; SPINE ; FGF23
英文摘要:

Objective GALNT3 gene encodes the glycosyltransferase polypeptide N-acetylgalactosaminyltransferase-3 (ppGalNacT3), which initiates the O-glycosylation of fibroblast growth factor 23 (FGF23) that is important in phosphorous regulation. Inactivating mutations of the GALNT3 gene can cause familial tumoral calcinosis. The aim of present study is to investigate the association of GALNT3 polymorphisms with osteoporosis phenotypes in Chinese postmenopausal women. Methods A community-based population of 1,353 postmenopausal women was randomly selected in Beijing. Bone mineral densities (BMDs) of the lumbar spine, femoral neck (FN), and total hip (TH) were measured by dual-energy x-ray absorptiometry. Vertebral fracture phenotypes were ascertained by vertebral x-ray reading. Osteoporotic fracture phenotypes were obtained from questionnaires. Single nucleotide polymorphisms of GALNT3 were determined by TaqMan allelic discrimination assay. Differences in BMD, serum phosphorus, or serum calcium across diverse genotypes or haplotypes were analyzed by general linear model analysis of covariance. Linear regression or logistic regression was used for association analyses of different osteoporosis phenotypes, phosphorous, or calcium. Partial correlation was used to investigate the relationship between phosphorus or calcium and BMD. Results We found that polymorphisms of rs1863196, rs6710518, and rs13429321 were significantly associated with FN BMD (P values of 0.002, 0.003, and 0.002, respectively). Polymorphisms of rs1863196, rs6710518, rs4667492, rs13429321, and rs6721582 were associated with TH BMD (P values of 0.002, 0.004, 0.037, 0.005, and 0.014, respectively). Haplotype-1 additive and dominant models were found to be associated with TH BMD (P values of 0.035 and 0.024, respectively). Haplotype-2 dominant model was found to be associated with FN BMD (P = 0.003) and TH BMD (P = 0.001). Conclusions GALNT3 may play a role in genetic susceptibility to osteoporosis among Chinese postmenopausal women. Efforts should be exerted to replicate our findings in other similar and ethnically diverse populations.

语种: 英语
所属项目编号: 81070687 ; 81170805 ; 2006BAI02B03 ; 2008ZX09312-016 ; 7121012 ; 2007-3029
项目资助者: National Natural Science Foundation of China ; National Science and Technology Pillar Program ; National Science and Technology Major Projects for "Major New Drug Innovation and Development" ; Beijing Natural Science Foundation ; Scientific Research Foundation of Beijing Medical Development
WOS记录号: WOS:000335829900014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63058
Appears in Collections:北京大学首钢医院_内分泌科_期刊论文

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作者单位: 1.Beijing Liangxiang Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Beijing Chaoyang Hosp, Dept Endocrinol, Beijing, Peoples R China
3.Beijing Haidian Hosp, Dept Endocrinol, Beijing, Peoples R China
4.China Rehabil Res Ctr, Dept Endocrinol, Beijing, Peoples R China
5.Chinese Peoples Liberat Army Gen Hosp, Dept Geriatr Endocrinol, Beijing, Peoples R China
6.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Minist Hlth, Dept Endocrinol,Key Lab Endocrinol, Beijing 100730, Peoples R China
7.Gen Hosp Second Artillery Force, Dept Cadre Unit, Beijing, Peoples R China
8.Peking Univ, Shougang Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
9.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Radiol, Beijing 100730, Peoples R China
10.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Gynecol & Obstet, Beijing 100730, Peoples R China

Recommended Citation:
Li, Nan,Wang, Xiran,Jiang, Yan,et al. Association of GALNT3 gene polymorphisms with bone mineral density in Chinese postmenopausal women: the Peking Vertebral Fracture study[J]. MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY,2014,21(5):515-521.
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