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学科主题临床医学
Gene expression patterns in human liver cancers
Chen, X; Cheung, ST; So, S; Fan, ST; Barry, C; Higgins, J; Lai, KM; Ji, JF; Dudoit, S; Ng, IOL; van de Rijn, M; Botstein, D; Brown, PO
刊名MOLECULAR BIOLOGY OF THE CELL
2002-06-01
DOI10.1091/mbc.02-02-0023
13期:6页:1929-1939
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]GENOME-WIDE ANALYSIS ; HEPATOCELLULAR-CARCINOMA ; OVEREXPRESSION ; IDENTIFICATION ; CELLS ; P53 ; MICROARRAYS ; PREDICTION
英文摘要

Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Using cDNA microarrays to characterize patterns of gene expression in HCC, we found consistent differences between the expression patterns in HCC compared with those seen in nontumor liver tissues. The expression patterns in HCC were also readily distinguished from those associated with tumors metastatic to liver. The global gene expression patterns intrinsic to each tumor were sufficiently distinctive that multiple tumor nodules from the same patient could usually be recognized and distinguished from all the others in the large sample set on the basis of their gene expression patterns alone. The distinctive gene expression patterns are characteristic of the tumors and not the patient; the expression programs seen in clonally independent tumor nodules in the same patient were no more similar than those in tumors from different patients. Moreover, clonally related tumor masses that showed distinct expression profiles were also distinguished by genotypic differences. Some features of the gene expression patterns were associated with specific phenotypic and genotypic characteristics of the tumors, including growth rate, vascular invasion, and p53 overexpression.

语种英语
WOS记录号WOS:000176418800012
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被引频次:524[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63059
专题北京大学临床肿瘤学院_肿瘤外科
作者单位1.Stanford Univ, Sch Med, Dept Biochem, Stanford, CA 94305 USA
2.Stanford Univ, Sch Med, Dept Surg, Stanford, CA 94305 USA
3.Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 USA
4.Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA
5.Beijing Canc Hosp, Dept Surg, Beijing, Peoples R China
6.Univ Hong Kong, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
7.Univ Hong Kong, Dept Surg, Hong Kong, Hong Kong, Peoples R China
8.Stanford Univ, Sch Med, Howard Hughes Med Inst, Stanford, CA 94305 USA
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Chen, X,Cheung, ST,So, S,et al. Gene expression patterns in human liver cancers[J]. MOLECULAR BIOLOGY OF THE CELL,2002,13(6):1929-1939.
APA Chen, X.,Cheung, ST.,So, S.,Fan, ST.,Barry, C.,...&Brown, PO.(2002).Gene expression patterns in human liver cancers.MOLECULAR BIOLOGY OF THE CELL,13(6),1929-1939.
MLA Chen, X,et al."Gene expression patterns in human liver cancers".MOLECULAR BIOLOGY OF THE CELL 13.6(2002):1929-1939.
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