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学科主题: 基础医学
题名:
Synergistic antitumor efficacy by combining adriamycin with recombinant human endostatin in an osteosarcoma model
作者: Xu, Hairong1; Niu, Xiaohui1; Zhang, Qing1; Hao, Lin1; Ding, Yi1; Liu, Weifeng1; Yao, Lu2
关键词: osteosarcoma ; antiangiogenic therapy ; combination therapy ; synergistic effect
刊名: ONCOLOGY LETTERS
发表日期: 2011-09-01
DOI: 10.3892/ol.2011.334
卷: 2, 期:5, 页:773-778
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: POSTOPERATIVE PROGRESSION ; ADJUVANT CHEMOTHERAPY ; PULMONARY METASTASIS ; TUMOR ANGIOGENESIS ; OSTEOGENIC-SARCOMA ; THERAPY ; CANCER ; GROWTH ; ANGIOSTATIN ; MICE
英文摘要:

In the last 15 years, chemotherapy-based therapeutic regimens for the treatment of osteosarcoma have failed to demonstrate improved survival rates. Novel approaches, including targeted therapy and antiangiogenic therapy, may provide new methods for the treatment of osteosarcoma, one of the most deadly malignant diseases. In the present study, the therapeutic efficacy of an endogenous angiogenesis inhibitor, endostatin, was tested in combination with the chemotherapeutic agent, adriamycin. BALB/c mice, aged 4-6 weeks were fed animal chow and had access to water ad libitum. The mice were divided into groups and injected with tumor cells. Immunohistochemical staining was performed to identify the microvessel density. The TUNEL technique was also used to determine the apoptotic index. The combination of endostatin and adriamycin produced marked synergistic antitumor activity in a mouse osteosarcoma model. These findings provide new guidelines for designing future clinical trials and for the application of currently available clinical drugs (endostatin has been approved for clinical use) in the treatment of osteosarcoma.

语种: 英语
WOS记录号: WOS:000293484400003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63061
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Beijing Ji Shui Tan Hosp, Dept Orthoped Oncol Surg, Beijing 100035, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100035, Peoples R China

Recommended Citation:
Xu, Hairong,Niu, Xiaohui,Zhang, Qing,et al. Synergistic antitumor efficacy by combining adriamycin with recombinant human endostatin in an osteosarcoma model[J]. ONCOLOGY LETTERS,2011,2(5):773-778.
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