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学科主题基础医学
Synergistic antitumor efficacy by combining adriamycin with recombinant human endostatin in an osteosarcoma model
Xu, Hairong1; Niu, Xiaohui1; Zhang, Qing1; Hao, Lin1; Ding, Yi1; Liu, Weifeng1; Yao, Lu2
关键词osteosarcoma antiangiogenic therapy combination therapy synergistic effect
刊名ONCOLOGY LETTERS
2011-09-01
DOI10.3892/ol.2011.334
2期:5页:773-778
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]POSTOPERATIVE PROGRESSION ; ADJUVANT CHEMOTHERAPY ; PULMONARY METASTASIS ; TUMOR ANGIOGENESIS ; OSTEOGENIC-SARCOMA ; THERAPY ; CANCER ; GROWTH ; ANGIOSTATIN ; MICE
英文摘要

In the last 15 years, chemotherapy-based therapeutic regimens for the treatment of osteosarcoma have failed to demonstrate improved survival rates. Novel approaches, including targeted therapy and antiangiogenic therapy, may provide new methods for the treatment of osteosarcoma, one of the most deadly malignant diseases. In the present study, the therapeutic efficacy of an endogenous angiogenesis inhibitor, endostatin, was tested in combination with the chemotherapeutic agent, adriamycin. BALB/c mice, aged 4-6 weeks were fed animal chow and had access to water ad libitum. The mice were divided into groups and injected with tumor cells. Immunohistochemical staining was performed to identify the microvessel density. The TUNEL technique was also used to determine the apoptotic index. The combination of endostatin and adriamycin produced marked synergistic antitumor activity in a mouse osteosarcoma model. These findings provide new guidelines for designing future clinical trials and for the application of currently available clinical drugs (endostatin has been approved for clinical use) in the treatment of osteosarcoma.

语种英语
WOS记录号WOS:000293484400003
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63061
专题北京大学基础医学院_病理学系
北京大学口腔医学院_第四门诊部
北京大学临床肿瘤学院_药剂科
北京大学临床肿瘤学院_乳腺中心实验室
作者单位1.Peking Univ, Beijing Ji Shui Tan Hosp, Dept Orthoped Oncol Surg, Beijing 100035, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100035, Peoples R China
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Xu, Hairong,Niu, Xiaohui,Zhang, Qing,et al. Synergistic antitumor efficacy by combining adriamycin with recombinant human endostatin in an osteosarcoma model[J]. ONCOLOGY LETTERS,2011,2(5):773-778.
APA Xu, Hairong.,Niu, Xiaohui.,Zhang, Qing.,Hao, Lin.,Ding, Yi.,...&Yao, Lu.(2011).Synergistic antitumor efficacy by combining adriamycin with recombinant human endostatin in an osteosarcoma model.ONCOLOGY LETTERS,2(5),773-778.
MLA Xu, Hairong,et al."Synergistic antitumor efficacy by combining adriamycin with recombinant human endostatin in an osteosarcoma model".ONCOLOGY LETTERS 2.5(2011):773-778.
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