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学科主题: 临床医学
题名:
Effect of Cordyceps sinensis on Renal Function of Patients with Chronic Allograft Nephropathy
作者: Zhang, Zhihong2; Wang, Xiangwei1; Zhang, Yuanning1; Ye, Gang1
关键词: Chronic allograft nephropathy ; Cordyceps sinensis ; Renal transplantation
刊名: UROLOGIA INTERNATIONALIS
发表日期: 2011
DOI: 10.1159/000323655
卷: 86, 期:3, 页:298-301
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: REJECTION
英文摘要:

Objective: To investigate the effect of Cordyceps sinensis (Bailing Capsule, fermented agent of C. sinensis) on renal function of patients with chronic allograft nephropathy (CAN). Methods: A total of 231 CAN patients who underwent transplantation between 2005 and 2008 and experienced chronic graft dysfunction were randomly divided into 2 groups. Patients in group A (n = 122) were treated with immunosuppressive agents and C. sinensis (2.0 g/day, 3 times a day), while patients in group B (n = 109) were treated with traditional immunosuppressive drugs. Serum creatinine (SCr), blood urea nitrogen (BUN), creatinine clearance rate (C(Cr)) and urinary protein in 24 h (24-hour Upro) of all patients were measured before and after treatment. Urinary concentrations of transforming growth factor (TGF)-beta(1), retinol-binding protein (RBP) and beta(2)-microglobulin (beta(2)-MG) were detected at the same time. Results: After 6-month treatment with C. sinensis, SCr and C(Cr) in group A were significantly improved (p < 0.05), while there was no significant improvement observed for group B. There was no significant change in BUN in groups A and B (p > 0.05). 24-hour Upro, RBP and beta(2)-MG were lower in group A after treatment with C. sinensis (p < 0.05 or p < 0.01), and urinary TGF-beta(1) in group A was significantly lower than the values before C. sinensis treatment (p < 0.05), but showed no change in patients of group B. In group A, renal function had improved in 72 cases, stabilized in 38 cases, and worsened in 12 cases. In group B, renal function had improved in 14 cases, stabilized in 50 cases, and worsened in 45 cases (p < 0.05). Conclusion: C. sinensis therapy is advantageous in improving renal function of CAN patients by retarding CAN progression. Copyright (C) 2011 S. Karger AG, Basel

语种: 英语
WOS记录号: WOS:000289724300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63062
Appears in Collections:北京大学首钢医院_泌尿外科_期刊论文

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作者单位: 1.Third Mil Med Univ, Affiliated Hosp 2, Ctr Nephropathy, Dept Urol & Renal Transplantat, Chongqing 400037, Peoples R China
2.Peking Univ, Shougang Hosp, Dept Urol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Zhihong,Wang, Xiangwei,Zhang, Yuanning,et al. Effect of Cordyceps sinensis on Renal Function of Patients with Chronic Allograft Nephropathy[J]. UROLOGIA INTERNATIONALIS,2011,86(3):298-301.
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