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Gender-Specific Effect of-102G > A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children
Liu, Fang-Hong; Song, Jie-Yun; Zhang, Yi-Ning; Ma, Jun; Wang, Hai-Jun
刊名INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
2015
DOI10.1155/2015/872506
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
资助者National Natural Science Foundation of China ; Major State Basic Research and Development Program of China (973 program) ; National Natural Science Foundation of China ; Major State Basic Research and Development Program of China (973 program)
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]INSIG2 GENE ; CHILDHOOD OBESITY ; VARIANT UPSTREAM ; ASSOCIATION ; RS7566605 ; POPULATION ; PHENOTYPES ; METABOLISM ; OVERWEIGHT ; JAPANESE
英文摘要

Background. Insulin induced gene 2 (INSIG2) encodes a protein that has a biological effect on regulation of adipocyte metabolism and body weight. This study aimed to investigate the association of INSIG2 gene -102G>A polymorphism with obesity related phenotypes in Chinese children and test gender-specific effects. Methods. The 2,030 independent individuals aged from 7 to 18 years, including 705 obese cases and 1,325 nonobese controls, were recruited from local schools. We measured the obesity-related phenotypes and detected the serum lipids. We genotype -102G>A polymorphism by using the matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS). Results. In all individuals, we found that the GG/GA genotype of INSIG2 -102G>A polymorphism was associated with risk of severe obesity (OR = 1.62, 95% CI: 1.11-2.36, and P = 0.012) under the dominant model. The association with severe obesity existed only in boys (OR = 1.91, 95% CI: 1.15-3.17, P = 0.012). The GG/GA genotype of -102G>A polymorphism was also associated with higher waist circumference (beta = 2.61 cm, P = 0.031) inboys. No similar association was found in girls. The polymorphism was not associated with other obesity-related phenotypes, neither in all individuals nor in gender-specific population. Conclusions. This study identified a gender-specific effect of INSIG2 -102G>A polymorphism on risk of severe obesity and waist circumference in Chinese boys.

语种英语
所属项目编号81172683 ; 2012CB517501
资助者National Natural Science Foundation of China ; Major State Basic Research and Development Program of China (973 program) ; National Natural Science Foundation of China ; Major State Basic Research and Development Program of China (973 program)
WOS记录号WOS:000357218600001
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63070
Collection北京大学公共卫生学院
作者单位Peking Univ, Sch Publ Hlth, Inst Child & Adolescent Hlth, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Liu, Fang-Hong,Song, Jie-Yun,Zhang, Yi-Ning,et al. Gender-Specific Effect of-102G > A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children[J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY,2015.
APA Liu, Fang-Hong,Song, Jie-Yun,Zhang, Yi-Ning,Ma, Jun,&Wang, Hai-Jun.(2015).Gender-Specific Effect of-102G > A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children.INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.
MLA Liu, Fang-Hong,et al."Gender-Specific Effect of-102G > A Polymorphism in Insulin Induced Gene 2 on Obesity in Chinese Children".INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2015).
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