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学科主题临床医学
The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China
Gao, Wen1; Cheng, Hong1; Hu, Fulian1; Li, Jiang1; Wang, Lihui1; Yang, Guibin2; Xu, Le3; Zheng, Xiaoli3
关键词Helicobacter pylori antibiotic resistance amoxicillin clarithromycin metronidazole tetracycline levofloxacin moxifloxacin
刊名HELICOBACTER
2010-10-01
15期:5页:460-466
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Microbiology
研究领域[WOS]Gastroenterology & Hepatology ; Microbiology
关键词[WOS]AGAR DILUTION METHOD ; ANTIMICROBIAL RESISTANCE ; TETRACYCLINE RESISTANCE ; ANTIBACTERIAL AGENTS ; CONSENSUS REPORT ; CLARITHROMYCIN ; METRONIDAZOLE ; AMOXICILLIN ; INFECTION ; LEVOFLOXACIN
英文摘要

Objectives:

To evaluate Helicobacter pylori antibiotics resistance evolution from 2000 to 2009 to amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin and moxifloxacin in Beijing, China.

Methods:

A total of 374 H. pylori strains isolated from 374 subjects who had undergone upper gastrointestinal endoscopy from 2000 to 2009 were collected and examined by E-test method for antibiotics susceptibility.

Results:

The average antibiotics resistance rates were 0.3% (amoxicillin), 37.2% (clarithromycin), 63.9% (metronidazole), 1.2% (tetracycline), 50.3% (levofloxacin) and 61.9% (moxifloxacin). Overall resistance to clarithromycin, metronidazole, and fluoroquinolone increased annually (from 14.8 to 65.4%, 38.9 to 78.8%, and 27.1 to 63.5%, in 2000 or 2006-2007 to 2009, respectively). The secondary resistance rates were much higher than primary rates to these antibiotics, which also increased annually in recent 10 years.

Conclusions:

The trend of clarithromycin, metronidazole, and fluoroquinolone resistance of H. pylori increased over time and the resistance to amoxicillin and tetracycline was infrequent and stable in Beijing. Clarithromycin, metronidazole, and fluoroquinolone should be used with caution for H. pylori eradication treatment.

语种英语
WOS记录号WOS:000281636600007
项目编号2005-1008
资助机构Beijing Medicine Research and Development Fund
引用统计
被引频次:78[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63074
专题北京大学第一临床医学院_消化科
作者单位1.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
2.Peking Univ, Aerosp Clin Coll, Dept Gastroenterol, Beijing 100871, Peoples R China
3.Beijing Hosp, Dept Gastroenterol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Gao, Wen,Cheng, Hong,Hu, Fulian,et al. The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China[J]. HELICOBACTER,2010,15(5):460-466.
APA Gao, Wen.,Cheng, Hong.,Hu, Fulian.,Li, Jiang.,Wang, Lihui.,...&Zheng, Xiaoli.(2010).The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China.HELICOBACTER,15(5),460-466.
MLA Gao, Wen,et al."The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China".HELICOBACTER 15.5(2010):460-466.
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