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学科主题: 临床医学
题名:
The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China
作者: Gao, Wen1; Cheng, Hong1; Hu, Fulian1; Li, Jiang1; Wang, Lihui1; Yang, Guibin2; Xu, Le3; Zheng, Xiaoli3
关键词: Helicobacter pylori ; antibiotic resistance ; amoxicillin ; clarithromycin ; metronidazole ; tetracycline ; levofloxacin ; moxifloxacin
刊名: HELICOBACTER
发表日期: 2010-10-01
卷: 15, 期:5, 页:460-466
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Microbiology
研究领域[WOS]: Gastroenterology & Hepatology ; Microbiology
关键词[WOS]: AGAR DILUTION METHOD ; ANTIMICROBIAL RESISTANCE ; TETRACYCLINE RESISTANCE ; ANTIBACTERIAL AGENTS ; CONSENSUS REPORT ; CLARITHROMYCIN ; METRONIDAZOLE ; AMOXICILLIN ; INFECTION ; LEVOFLOXACIN
英文摘要:

Objectives:

To evaluate Helicobacter pylori antibiotics resistance evolution from 2000 to 2009 to amoxicillin, clarithromycin, metronidazole, tetracycline, levofloxacin and moxifloxacin in Beijing, China.

Methods:

A total of 374 H. pylori strains isolated from 374 subjects who had undergone upper gastrointestinal endoscopy from 2000 to 2009 were collected and examined by E-test method for antibiotics susceptibility.

Results:

The average antibiotics resistance rates were 0.3% (amoxicillin), 37.2% (clarithromycin), 63.9% (metronidazole), 1.2% (tetracycline), 50.3% (levofloxacin) and 61.9% (moxifloxacin). Overall resistance to clarithromycin, metronidazole, and fluoroquinolone increased annually (from 14.8 to 65.4%, 38.9 to 78.8%, and 27.1 to 63.5%, in 2000 or 2006-2007 to 2009, respectively). The secondary resistance rates were much higher than primary rates to these antibiotics, which also increased annually in recent 10 years.

Conclusions:

The trend of clarithromycin, metronidazole, and fluoroquinolone resistance of H. pylori increased over time and the resistance to amoxicillin and tetracycline was infrequent and stable in Beijing. Clarithromycin, metronidazole, and fluoroquinolone should be used with caution for H. pylori eradication treatment.

语种: 英语
所属项目编号: 2005-1008
项目资助者: Beijing Medicine Research and Development Fund
WOS记录号: WOS:000281636600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63074
Appears in Collections:北京大学第一临床医学院_消化内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 1, Dept Gastroenterol, Beijing 100034, Peoples R China
2.Peking Univ, Aerosp Clin Coll, Dept Gastroenterol, Beijing 100871, Peoples R China
3.Beijing Hosp, Dept Gastroenterol, Beijing, Peoples R China

Recommended Citation:
Gao, Wen,Cheng, Hong,Hu, Fulian,et al. The Evolution of Helicobacter pylori Antibiotics Resistance Over 10 Years in Beijing, China[J]. HELICOBACTER,2010,15(5):460-466.
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