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学科主题临床医学
NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population
Li, Zhe-Xuan; Wang, Yu-Mei; Tang, Fu-Bing; Zhang, Lian; Zhang, Yang; Ma, Jun-Ling; Zhou, Tong; You, Wei-Cheng; Pan, Kai-Feng
刊名PLOS ONE
2015-05-01
DOI10.1371/journal.pone.0124949
10期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]HELICOBACTER-PYLORI INFECTION ; CAG PATHOGENICITY ISLAND ; NF-KAPPA-B ; PRECANCEROUS LESIONS ; INNATE IMMUNITY ; POLYMORPHISMS ; CARCINOGENESIS ; CLASSIFICATION ; SUSCEPTIBILITY ; NOD1/CARD4
英文摘要

Background

Genetic variants of nucleotide-binding oligomerization domain-containing protein (NOD) may influence the outcome of Helicobacter pylori (H. pylori) infection and gastric carcinogenesis. To explore genetic variants of NOD1 and NOD2 in association with gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, China.

Methods

TagSNPs of NOD1 and NOD2 were genotyped by Sequenom MASS array in 132 GCs, and 1,198 subjects with precancerous gastric lesions, and were correlated with evolution of gastric lesions in 766 subjects with follow-up data.

Results

Among seven tagSNPs, NOD1 rs2709800 and NOD2 rs718226 were associated with gastric lesions. NOD1 rs2709800 TG genotype carriers had a decreased risk of intestinal metaplasia (IM, OR: 0.53; 95% CI: 0.31-0.92), while NOD2 rs718226 G allele (AG/GG) showed increased risks of dysplasia (DYS, OR: 2.96; 95% CI: 1.86-4.71) and GC (OR: 2.35; 95% CI: 1.24-4.46). Moreover, an additive interaction between rs718226 and H. pylori was found in DYS or GC with synergy index of 3.08 (95% CI: 1.38-6.87) or 3.99 (95% CI: 1.55-10.22), respectively. The follow-up data indicated that NOD2 rs2111235 C allele (OR: 0.52; 95% CI: 0.32-0.83) and rs7205423 G allele (OR: 0.56; 95% CI: 0.35-0.89) were associated with decreased risk of progression in H. pylori-infected subjects.

Conclusions

NOD1 rs2709800, NOD2 rs718226, rs2111235, rs7205423 and interaction between rs718226 and H. pylori infection may be related to risk of gastric lesions.

语种英语
WOS记录号WOS:000353887100067
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63082
专题北京大学临床肿瘤学院_流行病学研究室
北京大学临床肿瘤学院_党院办公室
作者单位Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Li, Zhe-Xuan,Wang, Yu-Mei,Tang, Fu-Bing,et al. NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population[J]. PLOS ONE,2015,10(5).
APA Li, Zhe-Xuan.,Wang, Yu-Mei.,Tang, Fu-Bing.,Zhang, Lian.,Zhang, Yang.,...&Pan, Kai-Feng.(2015).NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population.PLOS ONE,10(5).
MLA Li, Zhe-Xuan,et al."NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population".PLOS ONE 10.5(2015).
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