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IR@PKUHSC  > 北京大学临床肿瘤学院  > 流行病学研究室  > 期刊论文
学科主题: 临床医学
题名:
NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population
作者: Li, Zhe-Xuan; Wang, Yu-Mei; Tang, Fu-Bing; Zhang, Lian; Zhang, Yang; Ma, Jun-Ling; Zhou, Tong; You, Wei-Cheng; Pan, Kai-Feng
刊名: PLOS ONE
发表日期: 2015-05-01
DOI: 10.1371/journal.pone.0124949
卷: 10, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: HELICOBACTER-PYLORI INFECTION ; CAG PATHOGENICITY ISLAND ; NF-KAPPA-B ; PRECANCEROUS LESIONS ; INNATE IMMUNITY ; POLYMORPHISMS ; CARCINOGENESIS ; CLASSIFICATION ; SUSCEPTIBILITY ; NOD1/CARD4
英文摘要:

Background

Genetic variants of nucleotide-binding oligomerization domain-containing protein (NOD) may influence the outcome of Helicobacter pylori (H. pylori) infection and gastric carcinogenesis. To explore genetic variants of NOD1 and NOD2 in association with gastric cancer (GC) and its precursors, a population-based study was conducted in Linqu County, China.

Methods

TagSNPs of NOD1 and NOD2 were genotyped by Sequenom MASS array in 132 GCs, and 1,198 subjects with precancerous gastric lesions, and were correlated with evolution of gastric lesions in 766 subjects with follow-up data.

Results

Among seven tagSNPs, NOD1 rs2709800 and NOD2 rs718226 were associated with gastric lesions. NOD1 rs2709800 TG genotype carriers had a decreased risk of intestinal metaplasia (IM, OR: 0.53; 95% CI: 0.31-0.92), while NOD2 rs718226 G allele (AG/GG) showed increased risks of dysplasia (DYS, OR: 2.96; 95% CI: 1.86-4.71) and GC (OR: 2.35; 95% CI: 1.24-4.46). Moreover, an additive interaction between rs718226 and H. pylori was found in DYS or GC with synergy index of 3.08 (95% CI: 1.38-6.87) or 3.99 (95% CI: 1.55-10.22), respectively. The follow-up data indicated that NOD2 rs2111235 C allele (OR: 0.52; 95% CI: 0.32-0.83) and rs7205423 G allele (OR: 0.56; 95% CI: 0.35-0.89) were associated with decreased risk of progression in H. pylori-infected subjects.

Conclusions

NOD1 rs2709800, NOD2 rs718226, rs2111235, rs7205423 and interaction between rs718226 and H. pylori infection may be related to risk of gastric lesions.

语种: 英语
所属项目编号: 2010DFB30310 ; 2010CB529303 ; 81171989
项目资助者: Ministry of Science and Technology, China ; National Basic Research Program of China [973 program] ; National Natural Science Foundation of China
WOS记录号: WOS:000353887100067
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63082
Appears in Collections:北京大学临床肿瘤学院_流行病学研究室_期刊论文

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作者单位: Peking Univ, Canc Hosp & Inst, Dept Canc Epidemiol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Li, Zhe-Xuan,Wang, Yu-Mei,Tang, Fu-Bing,et al. NOD1 and NOD2 Genetic Variants in Association with Risk of Gastric Cancer and Its Precursors in a Chinese Population[J]. PLOS ONE,2015,10(5).
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