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Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation
Xie, Min; Fu, Hai-Xia; Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Han, Wei; Liu, Kai-Yan; Huang, Xiao-Jun
关键词Immune reconstitution B cell Cytomegalovirus Haploidentical Hematopoietic stem cell transplantation Graft-versus-host disease
刊名INTERNATIONAL JOURNAL OF HEMATOLOGY
2012-07-01
DOI10.1007/s12185-012-1099-5
96期:1页:109-121
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; B-LINEAGE LYMPHOCYTES ; CYTOMEGALOVIRUS-INFECTION ; HEMATOLOGICAL MALIGNANCIES ; IMMUNE-DEFICIENCY ; GRAFT ; RECIPIENTS ; RECOVERY
英文摘要

In patients undergoing hematopoietic stem cell transplantation (HSCT), B cells exert important, prolonged effects that provide protection from infection. In this study, we analyzed characteristics and influencing factors of CD19+ B cell reconstitution in 83 patients who underwent unmanipulated haploidentical/mismatched blood and bone marrow transplantation. Of these patients, 45 % showed a normal CD19+ B cell count at +360 days. Factors associated with lower CD19+ B cell levels were as follows: aGVHD grades II-IV had a trend to affect CD19+ B cell reconstitution at +180 days; clinically extensive cGVHD was significantly associated with CD19+ B cell deficiency at +360 days and serum IgG level at +180 and +360 days; cytomegalovirus (CMV) infection occurred after +38 days was correlated with lower B cell level at both +90 and +360 days, while those occurred before +38 days did not show this effect; glucocorticoids used around +90 and +180 days was associated with lower CD19+ B cell levels at +90 and +360 days, respectively, especially in patients that did not experience extensive cGVHD. In contrast, the number of HLA-mismatched locus positively correlated with CD19+ B cell at +90 days and serum IgG level at +180 days. In conclusion, CD19+ B cell recovery after haploidentical/mismatched HSCT was mainly influenced by GVHD and/or its treatment, CMV infection that occurred later (after +38 days) and use of glucocorticoids. Improvement of B cell recovery is likely to be achieved through effective prophylaxis of GVHD, minimized use of glucocorticoids, and preemptive treatment of CMV infection occurring after +38 days. More HLA-mismatched loci may initiate a stronger humoral response toward alloantigens > 180 days after HSCT, which may be beneficial for the eradication of minimal residual disease and protection from infection.

语种英语
WOS记录号WOS:000306430100013
项目编号7122193 ; 20110001110039
资助机构Beiijng Science Foundation of China ; Higher school specialized research fund ; Ministry of Education for excellent doctorial candidates of China
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63084
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xie, Min,Fu, Hai-Xia,Chang, Ying-Jun,et al. Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2012,96(1):109-121.
APA Xie, Min.,Fu, Hai-Xia.,Chang, Ying-Jun.,Xu, Lan-Ping.,Liu, Dai-Hong.,...&Huang, Xiao-Jun.(2012).Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation.INTERNATIONAL JOURNAL OF HEMATOLOGY,96(1),109-121.
MLA Xie, Min,et al."Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation".INTERNATIONAL JOURNAL OF HEMATOLOGY 96.1(2012):109-121.
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