北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation
作者: Xie, Min; Fu, Hai-Xia; Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Han, Wei; Liu, Kai-Yan; Huang, Xiao-Jun
关键词: Immune reconstitution ; B cell ; Cytomegalovirus ; Haploidentical ; Hematopoietic stem cell transplantation ; Graft-versus-host disease
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2012-07-01
DOI: 10.1007/s12185-012-1099-5
卷: 96, 期:1, 页:109-121
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; B-LINEAGE LYMPHOCYTES ; CYTOMEGALOVIRUS-INFECTION ; HEMATOLOGICAL MALIGNANCIES ; IMMUNE-DEFICIENCY ; GRAFT ; RECIPIENTS ; RECOVERY
英文摘要:

In patients undergoing hematopoietic stem cell transplantation (HSCT), B cells exert important, prolonged effects that provide protection from infection. In this study, we analyzed characteristics and influencing factors of CD19+ B cell reconstitution in 83 patients who underwent unmanipulated haploidentical/mismatched blood and bone marrow transplantation. Of these patients, 45 % showed a normal CD19+ B cell count at +360 days. Factors associated with lower CD19+ B cell levels were as follows: aGVHD grades II-IV had a trend to affect CD19+ B cell reconstitution at +180 days; clinically extensive cGVHD was significantly associated with CD19+ B cell deficiency at +360 days and serum IgG level at +180 and +360 days; cytomegalovirus (CMV) infection occurred after +38 days was correlated with lower B cell level at both +90 and +360 days, while those occurred before +38 days did not show this effect; glucocorticoids used around +90 and +180 days was associated with lower CD19+ B cell levels at +90 and +360 days, respectively, especially in patients that did not experience extensive cGVHD. In contrast, the number of HLA-mismatched locus positively correlated with CD19+ B cell at +90 days and serum IgG level at +180 days. In conclusion, CD19+ B cell recovery after haploidentical/mismatched HSCT was mainly influenced by GVHD and/or its treatment, CMV infection that occurred later (after +38 days) and use of glucocorticoids. Improvement of B cell recovery is likely to be achieved through effective prophylaxis of GVHD, minimized use of glucocorticoids, and preemptive treatment of CMV infection occurring after +38 days. More HLA-mismatched loci may initiate a stronger humoral response toward alloantigens > 180 days after HSCT, which may be beneficial for the eradication of minimal residual disease and protection from infection.

语种: 英语
所属项目编号: 7122193 ; 20110001110039
项目资助者: Beiijng Science Foundation of China ; Higher school specialized research fund ; Ministry of Education for excellent doctorial candidates of China
WOS记录号: WOS:000306430100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63084
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Xie, Min,Fu, Hai-Xia,Chang, Ying-Jun,et al. Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2012,96(1):109-121.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xie, Min]'s Articles
[Fu, Hai-Xia]'s Articles
[Chang, Ying-Jun]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xie, Min]‘s Articles
[Fu, Hai-Xia]‘s Articles
[Chang, Ying-Jun]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace