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IR@PKUHSC  > 北京大学第二临床医学院  > 血液科  > 期刊论文
学科主题: 临床医学
题名:
Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation
作者: Xie, Min; Fu, Hai-Xia; Chang, Ying-Jun; Xu, Lan-Ping; Liu, Dai-Hong; Zhang, Xiao-Hui; Han, Wei; Liu, Kai-Yan; Huang, Xiao-Jun
关键词: Immune reconstitution ; B cell ; Cytomegalovirus ; Haploidentical ; Hematopoietic stem cell transplantation ; Graft-versus-host disease
刊名: INTERNATIONAL JOURNAL OF HEMATOLOGY
发表日期: 2012-07-01
DOI: 10.1007/s12185-012-1099-5
卷: 96, 期:1, 页:109-121
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology
研究领域[WOS]: Hematology
关键词[WOS]: VERSUS-HOST-DISEASE ; BONE-MARROW-TRANSPLANTATION ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; B-LINEAGE LYMPHOCYTES ; CYTOMEGALOVIRUS-INFECTION ; HEMATOLOGICAL MALIGNANCIES ; IMMUNE-DEFICIENCY ; GRAFT ; RECIPIENTS ; RECOVERY
英文摘要:

In patients undergoing hematopoietic stem cell transplantation (HSCT), B cells exert important, prolonged effects that provide protection from infection. In this study, we analyzed characteristics and influencing factors of CD19+ B cell reconstitution in 83 patients who underwent unmanipulated haploidentical/mismatched blood and bone marrow transplantation. Of these patients, 45 % showed a normal CD19+ B cell count at +360 days. Factors associated with lower CD19+ B cell levels were as follows: aGVHD grades II-IV had a trend to affect CD19+ B cell reconstitution at +180 days; clinically extensive cGVHD was significantly associated with CD19+ B cell deficiency at +360 days and serum IgG level at +180 and +360 days; cytomegalovirus (CMV) infection occurred after +38 days was correlated with lower B cell level at both +90 and +360 days, while those occurred before +38 days did not show this effect; glucocorticoids used around +90 and +180 days was associated with lower CD19+ B cell levels at +90 and +360 days, respectively, especially in patients that did not experience extensive cGVHD. In contrast, the number of HLA-mismatched locus positively correlated with CD19+ B cell at +90 days and serum IgG level at +180 days. In conclusion, CD19+ B cell recovery after haploidentical/mismatched HSCT was mainly influenced by GVHD and/or its treatment, CMV infection that occurred later (after +38 days) and use of glucocorticoids. Improvement of B cell recovery is likely to be achieved through effective prophylaxis of GVHD, minimized use of glucocorticoids, and preemptive treatment of CMV infection occurring after +38 days. More HLA-mismatched loci may initiate a stronger humoral response toward alloantigens > 180 days after HSCT, which may be beneficial for the eradication of minimal residual disease and protection from infection.

语种: 英语
所属项目编号: 7122193 ; 20110001110039
项目资助者: Beiijng Science Foundation of China ; Higher school specialized research fund ; Ministry of Education for excellent doctorial candidates of China
WOS记录号: WOS:000306430100013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/63084
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China

Recommended Citation:
Xie, Min,Fu, Hai-Xia,Chang, Ying-Jun,et al. Characteristics and influencing factors of CD19+B cell reconstitution in patients following haploidentical/mismatched hematopoietic stem cell transplantation[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2012,96(1):109-121.
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