IR@PKUHSC  > 北京大学基础医学院  > 神经生物学系
学科主题基础医学
Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain
Qu, Xiao-Xiu; Cai, Jie; Li, Ming-Jia; Chi, Ye-Nan; Liao, Fei-Fei; Liu, Feng-Yu; Wan, You; Han, Ji-Sheng; Xing, Guo-Gang1
关键词Nr2b-containing Nmda Receptors Neuropathic Pain Long-term Potentiation Spinal Dorsal Horn Wdr Neurons Electrophysiology
刊名EXPERIMENTAL NEUROLOGY
2009-02-01
DOI10.1016/j.expneurol.2008.10.018
215期:2页:298-307
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]LONG-TERM POTENTIATION ; METHYL-D-ASPARTATE ; FIBER-EVOKED POTENTIALS ; DORSAL-HORN NEURONS ; NR2B SUBUNIT ; RAT MODEL ; CENTRAL SENSITIZATION ; NERVE LIGATION ; MECHANICAL HYPERALGESIA ; SYNAPTIC-TRANSMISSION
英文摘要

Activation of N-methyl-D-aspartate (NMDA) receptors in the spinal dorsal horn has been shown to be essential for the initiation of central sensitization and the hyperexcitability of dorsal horn neurons in chronic pain. However, whether the spinal NR2B-containing NMDA (NMDA-2B) receptors are involved still remains largely unclear. Using behavioral test and in vivo extracellular electrophysiological recording in L5 spinal nerve-ligated (SNL) neuropathic rats, we investigate the roles of spinal cord NMDA-2B receptors in the development of neuropathic pain. Our study showed that intrathecal (i.t.) injection of Ro 25-6981, a selective NMDA-2B receptor antagonist, had a dose-dependent anti-allodynic effect without causing motor dysfunction. Furthermore, i.t. application of another NMDA-2B receptor antagonist ifenprodil prior to SNL also significantly inhibited the mechanical allodynia but not the thermal hyperalgesia. These data suggest that NMDA-2B receptors at the spinal cord level play an important role in the development of neuropathic pain, especially at the early stage following nerve injury. In addition, spinal administration of Ro 25-6981 not only had a dose-dependent inhibitory effect on the C-fiber responses of dorsal horn wide dynamic range (WDR) neurons in both normal and SNL rats, but also significantly inhibited the long-term potentiation (LTP) in the C-fiber responses of WDR neurons induced by high-frequency stimulation (HFS) applied to the sciatic nerve. These results indicate that activation of the dorsal horn NMDA-2B receptors may be crucial for the spinal nociceptive synaptic transmission and for the development of long-lasting spinal hyperexcitability following nerve injury. In conclusion, the spinal cord NMDA-2B receptors play a role in the development of central sensitization and neuropathic pain via the induction of LTP in dorsal horn nociceptive synaptic transmission. Therefore, the spinal cord NMDA-2B receptor is likely to be a target for clinical pain therapy. (c) 2008 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000262890900012
项目编号30370470 ; 2007CB512500
资助机构National Natural Science Foundation of China ; National Basic Research Program of China
引用统计
被引频次:94[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/63089
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
3.Minist Educ, Key Lab Neurosci, Beijing 100191, Peoples R China
4.Minist Publ Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Qu, Xiao-Xiu,Cai, Jie,Li, Ming-Jia,et al. Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain[J]. EXPERIMENTAL NEUROLOGY,2009,215(2):298-307.
APA Qu, Xiao-Xiu.,Cai, Jie.,Li, Ming-Jia.,Chi, Ye-Nan.,Liao, Fei-Fei.,...&Xing, Guo-Gang.(2009).Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain.EXPERIMENTAL NEUROLOGY,215(2),298-307.
MLA Qu, Xiao-Xiu,et al."Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain".EXPERIMENTAL NEUROLOGY 215.2(2009):298-307.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Role of the spinal c(1234KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Qu, Xiao-Xiu]的文章
[Cai, Jie]的文章
[Li, Ming-Jia]的文章
百度学术
百度学术中相似的文章
[Qu, Xiao-Xiu]的文章
[Cai, Jie]的文章
[Li, Ming-Jia]的文章
必应学术
必应学术中相似的文章
[Qu, Xiao-Xiu]的文章
[Cai, Jie]的文章
[Li, Ming-Jia]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Role of the spinal cord NR2B-containing NMDA receptors in the development of neuropathic pain.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。